Frank McCormick

Frederick National Laboratory for Cancer Research

Also affiliated with UCSF Helen Diller Family Comprehensive Cancer Center

Biochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 47 papers. Top paper: “Oncogenic Signaling Pathways in The Cancer Genome Atlas”.

Oncogenic Signaling Pathways in The Cancer Genome Atlas

Cell(2018)10.1016/j.cell.2018.03.035

N/A

1.2DataRank · unranked

3322 citations

Marco Mina, Joshua Armenia, Walid K. Chatila, Augustin Luna, Konnor C. La +891 more

Targeted mass-spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP kinase, and AKT signaling

Cell Reports Methods(2021)10.1016/j.crmeth.2021.100015

N/A

0.868DataRank · unranked

22 citations

Kanika Sharma, Melissa Hoffman, Eric Kuhn, Lei Zhao, Alexandra R. Cocco +19 more

ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1

Molecular Cell(2022)10.1016/j.molcel.2022.04.034

N/A

0.841DataRank · unranked

23 citations

Radha Mukherjee, Rona Yaeger, Jieun Son, Jianing Xu, Na Na +22 more

Machine learning–driven multiscale modeling reveals lipid-dependent dynamics of RAS signaling proteins

Proceedings of the National Academy of Sciences(2022)10.1073/pnas.2113297119

N/A

0.675DataRank · unranked

89 citations

Chris Neale, Timothy S. Carpenter, Rebika Shrestha, César A. López, Timothy H. Tran +37 more

Structure of the SHOC2–MRAS–PP1C complex provides insights into RAF activation and Noonan syndrome

Nature Structural & Molecular Biology(2022)10.1038/s41594-022-00841-4

N/A

0.601DataRank · unranked

54 citations

Patrick Alexander, Kelly Snead, Nicole Hartig, Matthew Drew, Simon Messing +8 more

Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation

Cancer Discovery(2022)10.1158/2159-8290.cd-21-1631

N/A

0.542DataRank · unranked

36 citations

Rahul S. Vedula, Antonio Cuevas-Navarro, Bin Lü, Simon J. Hogg, Eric Wang +22 more

Biophysical and structural analysis of KRAS switch-II pocket inhibitors reveals allele-specific binding constraints

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.110331

N/A

0.540DataRank · unranked

15 citations

Albert H. Chan, Dana Rabara, Monalisa Swain, Erik K. Larsen, Marcin Dyba +11 more

Revealing the mechanism of action of a first-in-class covalent inhibitor of KRASG12C (ON) and other functional properties of oncogenic KRAS by 31P NMR

Journal of Biological Chemistry(2024)10.1016/j.jbc.2024.105650

N/A

0.464DataRank · unranked

21 citations

Jun Pei, Yue Yang, Marcin Dyba, Brian D. Smith, Dana Rabara +11 more

Functional interactions between neurofibromatosis tumor suppressors underlie Schwann cell tumor de-differentiation and treatment resistance

Nature Communications(2024)10.1038/s41467-024-44755-9

N/A

0.464DataRank · unranked

21 citations

Emily Payne, Cyrille L. Delley, Siyuan Liu, Kanish Mirchia, Matthew J. Sale +16 more

The ribosomal S6 kinase 2 (RSK2)–SPRED2 complex regulates the phosphorylation of RSK substrates and MAPK signaling

Journal of Biological Chemistry(2023)10.1016/j.jbc.2023.104789

N/A

0.396DataRank · unranked

13 citations

Daniel A. Bonsor, Matthew J. Sale, Anatoly Urisman, Jennifer Mehalko, Miranda Cabanski-Dunning +4 more

Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activity

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.10.22.618529

N/A

0.391DataRank · unranked

9 citations

Julien Dilly, Shengwu Liu, Eejung Kim, Yuemin Bian, Srisathiyanarayanan Dharmaiah +24 more

Structure of the SHOC2–MRAS–PP1C complex provides insights into RAF activation and Noonan syndrome

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.05.10.491335

N/A

0.241DataRank · unranked

4 citations

Patrick Alexander, Kelly Snead, Nicole Hartig, Matthew Drew, Simon Messing +8 more

UDP-glucose pyrophosphorylase 2, a regulator of glycogen synthesis and glycosylation, is critical for pancreatic cancer growth

Proceedings of the National Academy of Sciences(2021)10.1073/pnas.2103592118

N/A

0DataRank · unranked

56 citations

Qingwen Zhou, Eneda Toska, Jacqueline Galeas, Angel A. Ku, Richard P. Koche +6 more

RAS interaction with Sin1 is dispensable for mTORC2 assembly and activity

Proceedings of the National Academy of Sciences(2021)10.1073/pnas.2103261118

N/A

0DataRank · unranked

39 citations

Srisathiyanarayanan Dharmaiah, Matthew J. Sale, Simon Messing, Gabrielle Rizzuto, Antonio Cuevas-Navarro +7 more

The RAS GTPase RIT1 compromises mitotic fidelity through spindle assembly checkpoint suppression

Current Biology(2021)10.1016/j.cub.2021.06.030

N/A

0DataRank · unranked

28 citations

Richard Van, Alice Cheng, Anatoly Urisman, Pau Castel, Frank McCormick +1 more

NMR 1H, 13C, 15N backbone resonance assignments of the T35S and oncogenic T35S/Q61L mutants of human KRAS4b in the active, GppNHp-bound conformation

Biomolecular NMR Assignments(2021)10.1007/s12104-021-10050-7

N/A

0DataRank · unranked

3 citations

Marcin Dyba, Marco Tonelli, Brian D. Smith, William Gillette, Dominic Esposito +4 more

Insights into the Cross Talk between Effector and Allosteric Lobes of KRAS from Methyl Conformational Dynamics

Journal of the American Chemical Society(2022)10.1021/jacs.2c00007

N/A

0DataRank · unranked

27 citations

Srisathiyanarayanan Dharmaiah, Troy Taylor, Simon Messing, William Gillette, Dominic Esposito +6 more

Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs

eLife(2022)10.7554/elife.76495

N/A

0DataRank · unranked

26 citations

Laura Rodriguez-Muñoz, Joaquím Grego‐Bessa, Alice Cheng, Katherine A Rauen, Anatoly Urisman +4 more

RAS at 40: Update from the RAS Initiative

Cancer Discovery(2022)10.1158/2159-8290.cd-21-1554

N/A

0DataRank · unranked

24 citations

Frank McCormick, Dwight V. Nissley

Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.01.04.474894

N/A

0DataRank · unranked

1 citations

Laura Rodríguez-Muñoz, Joaquím Grego‐Bessa, Alice Cheng, Katherine A. Rauen, Anatoly Urisman +4 more

Ras-dependent RAF-MAPK hyperactivation by pathogenic RIT1 is a therapeutic target in Noonan syndrome-associated cardiac hypertrophy

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.11.02.514888

N/A

0DataRank · unranked

1 citations

Morgan E. Wagner, Richard Van, Monalisa Swain, Madeline R. Allison, Alice Cheng +7 more

Destabilizing NF1 variants act in a dominant negative manner through neurofibromin dimerization

Proceedings of the National Academy of Sciences(2023)10.1073/pnas.2208960120

N/A

0DataRank · unranked

31 citations

Ruby Goldstein de Salazar, Sae‐Won Han, Zi Yi Stephanie Huang, Alan Merk, Matthew Drew +11 more

RAS-dependent RAF-MAPK hyperactivation by pathogenic RIT1 is a therapeutic target in Noonan syndrome–associated cardiac hypertrophy

Science Advances(2023)10.1126/sciadv.adf4766

N/A

0DataRank · unranked

25 citations

Morgan E. Wagner, Richard Van, Monalisa Swain, Stephanie Mo, John Columbus +10 more

Reduced dynamic complexity allows structure elucidation of an excited state of KRASG13D

Communications Biology(2023)10.1038/s42003-023-04960-6

N/A

0DataRank · unranked

16 citations

Albert H. Chan, Srisathiyanarayanan Dharmaiah, Charles D. Schwieters, Timothy H. Tran, Troy Taylor +7 more

Data from Adaptive Resistance to Dual BRAF/MEK Inhibition in BRAF-Driven Tumors through Autocrine FGFR Pathway Activation

(2023)10.1158/1078-0432.c.6527784.v1

N/A

0DataRank · unranked

0 citations

Jenny Y. Xue, Dennie T. Frederick, Yi Cao, Eva Lin, Catherine Wilson +8 more

Data from Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation

(2023)10.1158/2159-8290.c.6549783

N/A

0DataRank · unranked

0 citations

Rahul S. Vedula, Antonio Cuevas-Navarro, Bin Lü, Simon J. Hogg, Eric Wang +22 more

Comparative analysis of KRAS4a and KRAS4b splice variants reveals distinctive structural and functional properties

Science Advances(2024)10.1126/sciadv.adj4137

N/A

0DataRank · unranked

38 citations

Timothy H. Tran, Megan Rigby, Ming Yi, Srisathiyanarayanan Dharmaiah, Timothy J. Waybright +12 more

Structural dynamics of RAF1-HSP90-CDC37 and HSP90 complexes reveal asymmetric client interactions and key structural elements

Communications Biology(2024)10.1038/s42003-024-05959-3

N/A

0DataRank · unranked

19 citations

Mayukh Chakrabarti, Gülçin Gülten, Joseph Finney, Carissa Grose, Tara Fox +7 more

Inhibition and degradation of NRAS with a pan-NRAS monobody

Oncogene(2024)10.1038/s41388-024-03186-y

N/A

0DataRank · unranked

9 citations

Gayatri Ketavarapu, Akiko Koide, Megan Mazzei, Mubashir J. Mintoo, Eliezra Glasser +7 more

The prominent pervasive oncogenic role and tissue specific permissiveness of RAS gene mutations

Scientific Reports(2024)10.1038/s41598-024-76591-8

N/A

0DataRank · unranked

2 citations

Daniel Soppet, Frank McCormick, Dwight V. Nissley, Ming Yi

Structural insights into isoform-specific RAS-PI3Kα interactions and the role of RAS in PI3Kα activation

Nature Communications(2025)10.1038/s41467-024-55766-x

N/A

0DataRank · unranked

32 citations

Wupeng Yan, Simon Messing, William Gillette, Takashi Tsuji, Mitsuhiro Yamaguchi +7 more

Blocking C-terminal processing of KRAS4b via a direct covalent attack on the CaaX-box cysteine

Proceedings of the National Academy of Sciences(2025)10.1073/pnas.2410766122

N/A

0DataRank · unranked

6 citations

Yue Yang, Alok K. Sharma, David M. Turner, Caroline J. DeHart, Hazem Abdelkarim +29 more

Dynamics and lipid membrane coupling of the RAS-RAF complex revealed via multiscale simulations

Biophysical Journal(2025)10.1016/j.bpj.2025.08.020

N/A

0DataRank · unranked

2 citations

Fikret Aydin, Chris Neale, Que N. Van, Xiaohua Zhang, Harsh Bhatia +35 more

A transcriptomic, proteomic, and functional genetic atlas dissects neurofibromin function in the peripheral nervous system

Proceedings of the National Academy of Sciences(2025)10.1073/pnas.2506823122

N/A

0DataRank · unranked

1 citations

Nadia Arang, Maria Sacconi Nunez, Patrick Kennedy, Emily Payne, Sarah Mohabeer +7 more

Modulation of the 14-3-3σ/C-RAF “auto”inhibited complex by molecular glues

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.07.30.667769

N/A

0DataRank · unranked

1 citations

Holly R. Vickery, Marloes Pennings, Johanna M. Virta, Emira J. Visser, Sean D. Bannier +9 more

NMR 1H, 13C, and 15N resonance assignments of the oncogenic Q61R variant of human NRAS in the active, GTP-bound conformation

Biomolecular NMR Assignments(2025)10.1007/s12104-025-10236-3

N/A

0DataRank · unranked

0 citations

Marco Tonelli, Marcin Dyba, William Gillette, Dominic Esposito, Dwight V. Nissley +3 more

Undermining Glutaminolysis Bolsters Chemotherapy While NRF2 Promotes Chemoresistance in KRAS-Driven Pancreatic Cancers

Cancer Research(2020)10.1158/0008-5472.can-19-1363

N/A

0DataRank · unranked

315 citations

Debanjan Goswami, Pavan P. Adiseshaiah, William Burgan, Ming Yi, Theresa M. Guerin +4 more

ssGSEA score-based Ras dependency indexes derived from gene expression data reveal potential Ras addiction mechanisms with possible clinical implications

Scientific Reports(2020)10.1038/s41598-020-66986-8

N/A

0DataRank · unranked

260 citations

Dwight V. Nissley, Frank McCormick, Robert M. Stephens, Ming Yi

Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR

Cell Reports(2020)10.1016/j.celrep.2020.107909

N/A

0DataRank · unranked

69 citations

Evan Markegard, Srisathiyanarayanan Dharmaiah, Anatoly Urisman, Matthew Drew, Dominic Esposito +5 more

Advancing RAS/RASopathy therapies: An NCI‐sponsored intramural and extramural collaboration for the study of RASopathies

American Journal of Medical Genetics Part A(2020)10.1002/ajmg.a.61485

N/A

0DataRank · unranked

63 citations

Megan N. Frone, Karen W. Gripp, Bruce D. Gelb, Lisa Schoyer, Lisa Schill +17 more

Uncovering a membrane-distal conformation of KRAS available to recruit RAF to the plasma membrane

Proceedings of the National Academy of Sciences(2020)10.1073/pnas.2006504117

N/A

0DataRank · unranked

58 citations

César A. López, Marco Tonelli, Troy Taylor, Ben Niu, Christopher B. Stanley +24 more

Membrane interactions of the globular domain and the hypervariable region of KRAS4b define its unique diffusion behavior

eLife(2020)10.7554/elife.47654

N/A

0DataRank · unranked

29 citations

De Chen, Yue Yang, Prabhakar R. Gudla, John Columbus, Karen M. Worthy +13 more

SPRED proteins and their roles in signal transduction, development, and malignancy

Genes & Development(2020)10.1101/gad.341222.120

N/A

0DataRank · unranked

55 citations

Frank McCormick, Claire Lorenzo

The RAS GTPase RIT1 compromises mitotic fidelity through spindle assembly checkpoint suppression

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.11.17.386177

N/A

0DataRank · unranked

2 citations

Richard Van, Alice Cheng, Anatoly Urisman, Pau Castel, Frank McCormick +1 more

UDP-glucose pyrophosphorylase 2, a regulator of glycosylation and glycogen, is essential for pancreatic cancer growth

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.10.13.337998

N/A

0DataRank · unranked

0 citations

Qingwen Zhou, Eneda Toska, Jacqueline Galeas, Angel A. Ku, Richard P. Koche +6 more

The metabolic landscape of RAS-driven cancers from biology to therapy

Nature Cancer(2021)10.1038/s43018-021-00184-x

N/A

0DataRank · unranked

355 citations

Matthew G. Vander Heiden, Frank McCormick, Suman Mukhopadhyay

KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation

Nature Communications(2021)10.1038/s41467-021-21422-x

N/A

0DataRank · unranked

253 citations

Albert H. Chan, Lucy C. Young, Lakshman Bindu, Chris Neale, Simon Messing +9 more