Zhan‐Guo Gao

Brown Foundation

Biochemistry, Genetics and Molecular BiologyMedicineNeuroscience

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 55 papers. Top paper: “Prohibitin Inactivation in Adipocytes Results in Reduced Lipid Metabolism and Adaptive Thermogenesis Impairment”.

Prohibitin Inactivation in Adipocytes Results in Reduced Lipid Metabolism and Adaptive Thermogenesis Impairment

Diabetes(2021)10.2337/db21-0094

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0.696DataRank · unranked

17 citations

Alexes C. Daquinag, Cale Fussell, Amel Djehal, Laurent Désaubry, Mikhail G. Kolonin +1 more

GPCR Agonist-to-Antagonist Conversion: Enabling the Design of Nucleoside Functional Switches for the A2A Adenosine Receptor

Journal of Medicinal Chemistry(2022)10.1021/acs.jmedchem.2c00462

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0.500DataRank · unranked

27 citations

Daejin Park, Gyudong Kim, Yoonji Lee, Xiyan Hou, Dnyandev B. Jarhad +12 more

Subtle Chemical Changes Cross the Boundary between Agonist and Antagonist: New A3 Adenosine Receptor Homology Models and Structural Network Analysis Can Predict This Boundary

Journal of Medicinal Chemistry(2021)10.1021/acs.jmedchem.1c00239

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0.464DataRank · unranked

21 citations

Xiyan Hou, Jin Hee Lee, Akshata Nayak, Varughese Alexander, Pankaz K. Sharma +7 more

Structure activity relationship of 3-nitro-2-(trifluoromethyl)-2H-chromene derivatives as P2Y6 receptor antagonists

Bioorganic & Medicinal Chemistry Letters(2021)10.1016/j.bmcl.2021.128008

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0.449DataRank · unranked

19 citations

Shanu Jain, Varun Gopinatth, Ngan B. Phung, Zhan‐Guo Gao, Kenneth A. Jacobson +1 more

A2B adenosine receptor activation and modulation by protein kinase C

iScience(2023)10.1016/j.isci.2023.107178

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0.292DataRank · unranked

6 citations

Ian M. Levitan, Asuka Inoue, Qiang Wei, Kenneth A. Jacobson, Zhan‐Guo Gao

Allosteric Antagonism of the A2A Adenosine Receptor by a Series of Bitopic Ligands

Cells(2020)10.3390/cells9051200

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15 citations

Kiran S. Toti, Ryan G. Campbell, R. Rama Suresh, Huijun Yang, Kenneth A. Jacobson +1 more

Assessment of biased agonism at the A3 adenosine receptor using β-arrestin and miniGαi recruitment assays

Biochemical Pharmacology(2020)10.1016/j.bcp.2020.113934

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43 citations

Dilip K. Tosh, Zhan‐Guo Gao, Kenneth A. Jacobson, Christophe P. Stove, Eline Pottie

Exploration of Alternative Scaffolds for P2Y14 Receptor Antagonists Containing a Biaryl Core

Journal of Medicinal Chemistry(2020)10.1021/acs.jmedchem.0c00745

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35 citations

Jinha Yu, Zhiwei Wen, Veronica Salmaso, Tadeusz Karcz, Ngan B. Phung +9 more

Correction to Accelerating the Throughput of Affinity Mass Spectrometry-Based Ligand Screening toward a G Protein-Coupled Receptor

Analytical Chemistry(2020)10.1021/acs.analchem.0c00754

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0 citations

Shanshan Qin, Bingjie Zhang, Antao Dai, Xiaoqing Cai, Mengna Ma +7 more

Structure activity and molecular modeling analyses of ribose- and base-modified uridine 5′-triphosphate analogues at the human P2Y2 and P2Y4 receptors

UNC Libraries(2020)10.17615/2w5x-0707

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0 citations

Zhan‐Guo Gao, T. Kendall Harden, Andrei A. Ivanov, Stefano Costanzi, Kenneth A. Jacobson +3 more

Fatty acid mobilization from adipose tissue is mediated by CD36 posttranslational modifications and intracellular trafficking

JCI Insight(2021)10.1172/jci.insight.147057

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76 citations

Zhan‐Guo Gao, Cale Fussell, Linnet Immaraj, Renata Pasqualini, Wadih Arap +4 more

Cellular and physiological circadian mechanisms drive diurnal cell proliferation and expansion of white adipose tissue

Nature Communications(2021)10.1038/s41467-021-23770-0

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36 citations

Rafael Bravo, Baharan Fekry, Yomna M. Tamim, Samay Shivshankar, Alaa M. T. Mohamed +11 more

Fragment-based design of selective GPCR ligands guided by free energy simulations

Chemical Communications(2021)10.1039/d1cc03202j

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20 citations

Duc Duy Vo, Zhan‐Guo Gao, Jan Kihlberg, Kenneth A. Jacobson, Jens Carlsson +1 more

Synthesis and evaluation of adenosine derivatives as A1, A2A, A2B and A3 adenosine receptor ligands containing boron clusters as phenyl isosteres and selective A3 agonists

European Journal of Medicinal Chemistry(2021)10.1016/j.ejmech.2021.113607

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15 citations

Adam Mieczkowski, Aleksandra Kierozalska, Dijana Saftić, Konrad Głąbała, Tomasz Przygodzki +8 more

Pharmacological characterization of DPTN and other selective A3 adenosine receptor antagonists

Purinergic Signalling(2021)10.1007/s11302-021-09823-5

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12 citations

R. Rama Suresh, Kenneth A. Jacobson, Zhan‐Guo Gao

A3 adenosine receptor agonists containing dopamine moieties for enhanced interspecies affinity

European Journal of Medicinal Chemistry(2021)10.1016/j.ejmech.2021.113983

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9 citations

Veronica Salmaso, Ryan G. Campbell, Harsha Rao, Amelia Bitant, Eline Pottie +7 more

Partial Ablation of Non-Myogenic Progenitor Cells as a Therapeutic Approach to Duchenne Muscular Dystrophy

Biomolecules(2021)10.3390/biom11101519

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5 citations

Aiping Lu, Alexes C. Daquinag, Yongmei Yu, Matthieu Huard, Chieh Tseng +4 more

Convergent synthesis of 2-thioether-substituted ( N )-methanocarba-adenosines as purine receptor agonists

RSC Advances(2021)10.1039/d1ra05096f

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4 citations

Russell B. Poe, Baorui Lin, Kexin Lv, Ryan G. Campbell, Zhan‐Guo Gao +4 more

Discovery of Highly Potent Adenosine A1 Receptor Agonists: Targeting Positron Emission Tomography Probes

ACS Chemical Neuroscience(2021)10.1021/acschemneuro.1c00397

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4 citations

Abolghasem Bakhoda, Zhan‐Guo Gao, Joseph M. Ramsey, Yang Li, Kelly A. O’Conor +12 more

Anti-diabetic effects of GLP1 analogs are mediated by thermogenic interleukin-6 signaling in adipocytes

Cell Reports Medicine(2022)10.1016/j.xcrm.2022.100813

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39 citations

Zhan‐Guo Gao, Vala Hamidi, Liang Zhu, Karla Bermudez Saint Andre, Kayla A. Riggs +8 more

Species dependence of A3 adenosine receptor pharmacology and function

Purinergic Signalling(2022)10.1007/s11302-022-09910-1

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30 citations

John A. Auchampach, Kenneth A. Jacobson, Zhan‐Guo Gao

The role of the aging microenvironment on the fate of PDGFRβ lineage cells in skeletal muscle repair

Stem Cell Research & Therapy(2022)10.1186/s13287-022-03072-y

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14 citations

Chieh Tseng, Ping Guo, Zhan‐Guo Gao, Kaitlyn E. Whitney, Mikhail G. Kolonin +2 more

Structure–Activity Studies of 1H-Imidazo[4,5-c]quinolin-4-amine Derivatives as A3 Adenosine Receptor Positive Allosteric Modulators

Journal of Medicinal Chemistry(2022)10.1021/acs.jmedchem.2c01170

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12 citations

R. Rama Suresh, Courtney Fisher, Veronica Salmaso, Robert D. O’Connor, Noy Kaufman +4 more

Effects of Purinergic Receptor Deletion or Pharmacologic Modulation on Pulmonary Inflammation in Mice

ACS Pharmacology & Translational Science(2022)10.1021/acsptsci.2c00128

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11 citations

Tadeusz Karcz, Dilip K. Tosh, Kwan‐Young Jung, Zhiwei Wen, Ryan G. Campbell +5 more

Fluorescent A2A and A3 adenosine receptor antagonists as flow cytometry probes

Purinergic Signalling(2022)10.1007/s11302-022-09873-3

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7 citations

Ryan G. Campbell, Hobin Lee, Veronica Salmaso, R. Rama Suresh, Zhan‐Guo Gao +2 more

Characterization of Dual-Acting A3 Adenosine Receptor Positive Allosteric Modulators That Preferentially Enhance Adenosine-Induced Gαi3 and GαoA Isoprotein Activation

ACS Pharmacology & Translational Science(2022)10.1021/acsptsci.2c00076

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13 citations

Lucas B. Fallot, Tina C. Wan, Robert F. Keyes, R. Rama Suresh, Amy C. Rothwell +6 more

Interaction of A3 adenosine receptor ligands with the human multidrug transporter ABCG2

European Journal of Medicinal Chemistry(2022)10.1016/j.ejmech.2022.114103

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8 citations

Megumi Murakami, Dilip K. Tosh, Jinha Yu, Sabrina Lusvarghi, Ryan G. Campbell +4 more

Selective A3 Adenosine Receptor Antagonist Radioligand for Human and Rodent Species

ACS Medicinal Chemistry Letters(2022)10.1021/acsmedchemlett.1c00685

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8 citations

Zhan‐Guo Gao, Veronica Salmaso, Eric Chen, Ryan G. Campbell, Russell B. Poe +3 more

Characterization of Novel A 3 Adenosine Receptor Allosteric Modulators

The FASEB Journal(2022)10.1096/fasebj.2022.36.s1.00r64

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0DataRank · unranked

0 citations

Tina C. Wan, Lucas B. Fallot, Robert F. Keyes, R. R. Suresh, Amy C. Rothwell +6 more

Anionic phospholipids control mechanisms of GPCR-G protein recognition

Nature Communications(2023)10.1038/s41467-023-36425-z

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0DataRank · unranked

100 citations

Arka Prabha Ray, Liam Sharp, Beining Jin, Alexander Duong, Niloofar Gopal Pour +8 more

Alicyclic Ring Size Variation of 4-Phenyl-2-naphthoic Acid Derivatives as P2Y 14 Receptor Antagonists

Journal of Medicinal Chemistry(2023)10.1021/acs.jmedchem.3c00664

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19 citations

Asmita Pramanik, Sarah A. Lewicki, Kwan‐Young Jung, Zhan‐Guo Gao, John C.R. Randle +10 more

Structure–Activity Relationship of Truncated 2,8-Disubstituted-Adenosine Derivatives as Dual A2A/A3 Adenosine Receptor Antagonists and Their Cancer Immunotherapeutic Activity

Journal of Medicinal Chemistry(2023)10.1021/acs.jmedchem.3c00806

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14 citations

Xiyan Hou, Woong Sub Byun, Gyudong Kim, Dnyandev B. Jarhad, Grim Lee +15 more

Gene expression in mice with endothelium-specific telomerase knockout

Frontiers in Cell and Developmental Biology(2023)10.3389/fcell.2023.1295072

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5 citations

Yongmei Yu, Yulin Dai, Zhongming Zhao, Kristin Eckel‐Mahan, Mikhail G. Kolonin +1 more

First Potent Macrocyclic A3 Adenosine Receptor Agonists Reveal G-Protein and β-Arrestin2 Signaling Preferences

ACS Pharmacology & Translational Science(2023)10.1021/acsptsci.3c00126

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4 citations

Courtney Fisher, Veronica Salmaso, Tina C. Wan, Ryan G. Campbell, Eric Chen +4 more

2-Amino-5-arylethynyl-thiophen-3-yl-(phenyl)methanones as A1 Adenosine Receptor Positive Allosteric Modulators

ACS Medicinal Chemistry Letters(2023)10.1021/acsmedchemlett.3c00315

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1 citations

R. Rama Suresh, Silvia Pasquini, Veronica Salmaso, E.J. Will, Dilip K. Tosh +7 more

Structure activity relationships of 5-HT2B and 5-HT2C serotonin receptor antagonists: N6, C2 and 5′-Modified (N)-methanocarba-adenosine derivatives

European Journal of Medicinal Chemistry(2023)10.1016/j.ejmech.2023.115691

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3 citations

Maggie M. Calkins, Marko Ivancich, Hailey A. Bock, Ryan G. Campbell, Sarah A. Lewicki +5 more

Terpenes from Cannabis sativa Induce Antinociception in Mouse Chronic Neuropathic Pain via Activation of Spinal Cord Adenosine A 2A Receptors

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.03.28.534594

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6 citations

Attila Keresztes, Thai Bui, Ryan Hecksel, Adrián F. Peña-Delgado, Brianna Lent +9 more

Anionic Phospholipids Control Mechanisms of GPCR-G Protein Recognition

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.01.11.523010

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2 citations

Arka Prabha Ray, Liam Sharp, Beining Jin, Alexander Duong, Niloofar Gopal Pour +8 more

Mesenchymal-specific Alms1 knockout in mice recapitulates key metabolic features of Alström Syndrome

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.10.12.562074

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1 citations

Ineke Luijten, Xiong Weng, Pablo B. Martínez de Morentin, Elvira De Frutos González, Zhan‐Guo Gao +4 more

Membrane Mimetic-Dependence of GPCR Energy Landscapes

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.10.16.562552

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1 citations

Arka Prabha Ray, Edward Lyman, Zhan‐Guo Gao, Kenneth A. Jacobson, Matthew T. Eddy +1 more

Membrane mimetic-dependence of GPCR energy landscapes

Structure(2024)10.1016/j.str.2024.01.013

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19 citations

Arka Prabha Ray, Beining Jin, Nessa Pesaran Afsharian, Edward Lyman, Zhan‐Guo Gao +3 more

Terpenes from Cannabis sativa induce antinociception in a mouse model of chronic neuropathic pain via activation of adenosine A2A receptors

Pain(2024)10.1097/j.pain.0000000000003265

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19 citations

Attila Keresztes, Thai Bui, Ryan Hecksel, Adrián F. Peña-Delgado, Brianna Lent +9 more

Extrahelical Binding Site for a 1H-Imidazo[4,5-c]quinolin-4-amine A3 Adenosine Receptor Positive Allosteric Modulator on Helix 8 and Distal Portions of Transmembrane Domains 1 and 7

Molecular Pharmacology(2024)10.1124/molpharm.123.000784

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10 citations

Matteo Pavan, Veronica Salmaso, Robert F. Keyes, Tina C. Wan, Balaram Pradhan +5 more

Machine learning-aided search for ligands of P2Y6 and other P2Y receptors

Purinergic Signalling(2024)10.1007/s11302-024-10003-4

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9 citations

Sarah A. Lewicki, Zhan‐Guo Gao, Asmita Pramanik, Vadim Makarov, Sean Ekins +2 more

Lipid Trolling to Optimize A3 Adenosine Receptor-Positive Allosteric Modulators (PAMs)

Journal of Medicinal Chemistry(2024)10.1021/acs.jmedchem.4c00944

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8 citations

Matteo Pavan, Courtney Fisher, Veronica Salmaso, Tina C. Wan, Robert F. Keyes +8 more

Structural Modification and Biological Evaluation of 2,8-Disubstituted Adenine and Its Nucleosides as A2A Adenosine Receptor Antagonists: Exploring the Roles of Ribose at Adenosine Receptors

Journal of Medicinal Chemistry(2024)10.1021/acs.jmedchem.4c01003

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6 citations

Dnyandev B. Jarhad, Grim Lee, Gyudong Kim, Xiyan Hou, Jinha Yu +17 more

Genetic and functional modulation by agonist MRS5698 and allosteric enhancer LUF6000 at the native A3 adenosine receptor in HL-60 cells

Purinergic Signalling(2024)10.1007/s11302-024-09992-z

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4 citations

Weiping Chen, Ray R. Gao, Jonathan Li, Dilip K. Tosh, John A. Hanover +2 more

Correction to “Structure–Activity Relationship of Truncated 2,8-Disubstituted-Adenosine Derivatives as Dual A2A/A3 Adenosine Receptor Antagonists and Their Cancer Immunotherapeutic Activity”

Journal of Medicinal Chemistry(2024)10.1021/acs.jmedchem.3c02442

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0 citations

Xiyan Hou, Woong Sub Byun, Gyudong Kim, Dnyandev B. Jarhad, Grim Lee +15 more

Caloric Restriction and Telomere Preservation in TERT Knockout Adipocyte Progenitors Does Not Rescue Mice From Metabolic Dysfunction due to a TERT Function in Adipocyte Mitochondria

Aging Cell(2025)10.1111/acel.14499

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5 citations

Yongmei Yu, Kristin Eckel‐Mahan, Mikhail G. Kolonin, Zhan‐Guo Gao

Adenosine A2A receptor antagonists: from caffeine to selective non‐xanthines

British Journal of Pharmacology(2020)10.1111/bph.15103

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110 citations

Zhan‐Guo Gao, Pierre Matricon, Matthew T. Eddy, Jens Carlsson, Kenneth A. Jacobson

Senescence caused by telomerase inactivation in myeloid, mesenchymal, and endothelial cells has distinct effects on cancer progression

Aging(2025)10.18632/aging.206268

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1 citations

Zhan‐Guo Gao, Yongmei Yu, Mikhail G. Kolonin, Joseph E. Rupert

Ligand design by targeting a binding site water

Chemical Science(2020)10.1039/d0sc04938g

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67 citations

R. Rama Suresh, Zhan‐Guo Gao, Nicolas Panel, Kenneth A. Jacobson, Jens Carlsson +1 more

Direct Comparison of (N)-Methanocarba and Ribose-Containing 2-Arylalkynyladenosine Derivatives as A3 Receptor Agonists

ACS Medicinal Chemistry Letters(2020)10.1021/acsmedchemlett.9b00637

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23 citations

Veronica Salmaso, Harsha Rao, Ryan G. Campbell, Amelia Bitant, Zhan‐Guo Gao +3 more

Truncated (N)-Methanocarba Nucleosides as Partial Agonists at Mouse and Human A3 Adenosine Receptors: Affinity Enhancement by N6-(2-Phenylethyl) Substitution

Journal of Medicinal Chemistry(2020)10.1021/acs.jmedchem.0c00235

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20 citations

Veronica Salmaso, Harsha Rao, Amelia Bitant, Courtney Fisher, David I. Lieberman +7 more

Novel cyanothiouracil and cyanothiocytosine derivatives as concentration-dependent selective inhibitors of U87MG glioblastomas: Adenosine receptor binding and potent PDE4 inhibition

European Journal of Medicinal Chemistry(2020)10.1016/j.ejmech.2020.113125

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17 citations

Sevde Nur Biltekin, Leyla Yurttaş, Barkın Berk, Yağmur Özhan, Hande Si̇pahi̇ +4 more