Frank J. Gonzalez

University of North Carolina at Chapel Hill

Also affiliated with National Institutes of Health, National Cancer Institute, Center for Cancer Research

Pharmacology, Toxicology and PharmaceuticsBiochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 97 papers. Top paper: “Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to PPARA agonism and fasting”.

Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to PPARA agonism and fasting

Nature Communications(2020)10.1038/s41467-020-19554-7

N/A

2.4DataRank · unranked

102 citations

Donghwan Kim, Tisha Melia, Kritika Karri, Thomas J. Velenosi, Shogo Takahashi +6 more

Metabolomic profiling of metoprolol hypertension treatment reveals altered gut microbiota-derived urinary metabolites

Human Genomics(2020)10.1186/s40246-020-00260-w

N/A

1.3DataRank · unranked

35 citations

Thomas J. Velenosi, Hania K. Flaten, Glenn McWilliams, Kyle McDaniel, Shelby K. Shelton +5 more

Changes in the type 2 diabetes gut mycobiome associate with metformin treatment across populations

mBio(2024)10.1128/mbio.00169-24

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0.423DataRank · unranked

9 citations

Michelle Pistner Nixon, Justin D. Silverman, Yuhong Luo, Frank J. Gonzalez, Ilze Elbere +5 more

Bile acid sequestration reverses liver injury and prevents progression of nonalcoholic steatohepatitis in Western diet–fed mice

Journal of Biological Chemistry(2020)10.1074/jbc.ra119.011913

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0DataRank · unranked

62 citations

Yuhuan Luo, Suman Ranjit, Cen Xie, Andrew E. Libby, David J. Orlicky +15 more

Upregulation of BDNF and hippocampal functions by a hippocampal ligand of PPARα

JCI Insight(2020)10.1172/jci.insight.136654

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0DataRank · unranked

47 citations

Avik Roy, Sumita Raha, Madhuchhanda Kundu, Frank J. Gonzalez, Kalipada Pahan +1 more

HNF1α controls glucagon secretion in pancreatic α-cells through modulation of SGLT1

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease(2020)10.1016/j.bbadis.2020.165898

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0DataRank · unranked

21 citations

Md Mostafizur Rahman, M Haneda, Tomonori Tsuyama, Tomoya Mizumoto, Tatsuya Yoshizawa +5 more

Improved detection and precise relative quantification of the urinary cancer metabolite biomarkers – Creatine riboside, creatinine riboside, creatine and creatinine by UPLC-ESI-MS/MS: Application to the NCI-Maryland cohort population controls and lung cancer cases

Journal of Pharmaceutical and Biomedical Analysis(2020)10.1016/j.jpba.2020.113596

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0DataRank · unranked

19 citations

Gary T. Pauly, Takeshi Tada, Amelia L. Parker, Leila Toulabi, Yasuyuki Kanke +5 more

Sex steroid hormones differentially regulate CYP2D in female wild-type and CYP2D6-humanized mice

Journal of Endocrinology(2020)10.1530/joe-19-0561

N/A

0DataRank · unranked

21 citations

Christina E. Andriopoulou, Jie Cheng, Frank J. Gonzalez, Maria Konstandi

Identification of a New Heterocyclic Scaffold for Inhibitors of the Polo-Box Domain of Polo-like Kinase 1

Journal of Medicinal Chemistry(2020)10.1021/acs.jmedchem.0c01669

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0DataRank · unranked

21 citations

Jung‐Eun Park, Kiran S. Toti, Yangliu Xia, Kristopher W. Krausz, Ganesha Rai +5 more

6β-Hydroxytestosterone, a metabolite of testosterone generated by CYP1B1, contributes to vascular changes in angiotensin II-induced hypertension in male mice

Biology of Sex Differences(2020)10.1186/s13293-019-0280-4

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0DataRank · unranked

20 citations

Brett L. Jennings, Kamalika Mukherjee, Wadah Akroush, Frank J. Gonzalez, Kafait U. Malik +1 more

A saturated fatty acid-rich diet enhances hepatic lipogenesis and tumorigenesis in HCV core gene transgenic mice

The Journal of Nutritional Biochemistry(2020)10.1016/j.jnutbio.2020.108460

N/A

0DataRank · unranked

17 citations

Xiaojing Wang, Fangping Jia, Takefumi Kimura, Xiao Hu, Saki Shirotori +9 more

Investigation on the metabolic characteristics of isobavachin in Psoralea corylifolia L. (Bu-gu-zhi) and its potential inhibition against human cytochrome P450s and UDP-glucuronosyltransferases

Journal of Pharmacy and Pharmacology(2020)10.1111/jphp.13337

N/A

0DataRank · unranked

12 citations

Jing Yang, Kaidi Ren, Zifei Qin, Peile Wang, Xiaojian Zhang +4 more

Synergistic regulation of hepatic Fsp27b expression by HNF4α and CREBH

Biochemical and Biophysical Research Communications(2020)10.1016/j.bbrc.2020.05.070

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0DataRank · unranked

10 citations

Masayuki Takizawa, W. Iwasaki, Shota Sasaki, Mume Hamada, Aoi Morimoto +4 more

Characterization of metabolic activity, isozyme contribution and species differences of bavachin, and identification of efflux transporters for bavachin-O-glucuronide in HeLa1A1 cells

Journal of Pharmacy and Pharmacology(2020)10.1111/jphp.13324

N/A

0DataRank · unranked

11 citations

Chunxia Xu, Jinjin Xu, Zifei Qin, Shishi Li, Liufang Hu +4 more

Human CYP2D6 in the Brain Is Protective Against Harmine-Induced Neurotoxicity: Evidence from Humanized CYP2D6 Transgenic Mice

Molecular Neurobiology(2020)10.1007/s12035-020-02050-w

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0DataRank · unranked

11 citations

Edgor Cole Tolledo, Fariba Baghai Wadji, Frank J. Gonzalez, Sharon Miksys, Rachel F. Tyndale +1 more

Metabolism and disposition of corylifol A from Psoralea corylifolia: metabolite mapping, isozyme contribution, species differences and identification of efflux transporters for corylifol A-O-glucuronide in HeLa1A1 cells

Xenobiotica(2020)10.1080/00498254.2020.1732496

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0DataRank · unranked

9 citations

Jinjin Xu, Chunxia Xu, Zifei Qin, Shishi Li, Liufang Hu +4 more

Dexamethasone-Induced Liver Enlargement Is Related to PXR/YAP Activation and Lipid Accumulation but Not Hepatocyte Proliferation

Drug Metabolism and Disposition(2020)10.1124/dmd.120.000061

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0DataRank · unranked

46 citations

Xinpeng Yao, Ying-Yuan Zhao, Yanying Zhou, Yue Gao, Shicheng Fan +8 more

Celastrol ameliorates acute liver injury through modulation of PPARα

Biochemical Pharmacology(2020)10.1016/j.bcp.2020.114058

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0DataRank · unranked

39 citations

Ping Tang, Ting Zhang, Jian‐Feng Huang, Xue‐Rong Xiao, Weifeng Zhu +3 more

MicroRNA-1291-5p Sensitizes Pancreatic Carcinoma Cells to Arginine Deprivation and Chemotherapy through the Regulation of Arginolysis and Glycolysis

Molecular Pharmacology(2020)10.1124/molpharm.120.000130

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0DataRank · unranked

36 citations

Zhijian Duan, Zhenzhen Liu, Chao Zhang, Richard J. Bold, Frank J. Gonzalez +3 more

Synthesis and structure-activity relationship of coumarins as potent Mcl-1 inhibitors for cancer treatment

Bioorganic & Medicinal Chemistry(2020)10.1016/j.bmc.2020.115851

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0DataRank · unranked

30 citations

Jingjing Wang, Shi-Yang Li, Yong Liu, Frank J. Gonzalez, Ping Wang +2 more

Central CYP1B1 (Cytochrome P450 1B1)-Estradiol Metabolite 2-Methoxyestradiol Protects From Hypertension and Neuroinflammation in Female Mice

Hypertension(2020)10.1161/hypertensionaha.119.14548

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0DataRank · unranked

27 citations

Chi Young Song, Shubha Ranjan Dutta, Frank J. Gonzalez, Kafait U. Malik, Purnima Singh

Hypoxia inducible factor 2α inhibition in vascular smooth muscle cells (VSMCs) abolishes abdominal aortic aneurysm in ApoE−/− mice

Journal of Molecular and Cellular Cardiology(2020)10.1016/j.yjmcc.2019.11.032

N/A

0DataRank · unranked

0 citations

Dan Qi, Xia Wang, Ye Liu, Guomin Xie, Baoqi Yu +5 more

Suppressing the intestinal farnesoid X receptor/sphingomyelin phosphodiesterase 3 axis decreases atherosclerosis

Journal of Clinical Investigation(2021)10.1172/jci142865

N/A

0DataRank · unranked

128 citations

Lulu Sun, Xiaomin Hu, Xuemei Wang, Feng Xu, Bo Chen +14 more

YAP‐TEAD mediates PPAR α–induced hepatomegaly and liver regeneration in mice

Hepatology(2021)10.1002/hep.32105

N/A

0DataRank · unranked

110 citations

Yue Gao, Aijuan Qu, Yiming Jiang, Hua Li, Guomin Xie +10 more

Myelocytomatosis‐Protein Arginine N‐Methyltransferase 5 Axis Defines the Tumorigenesis and Immune Response in Hepatocellular Carcinoma

Hepatology(2021)10.1002/hep.31864

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0DataRank · unranked

59 citations

Yuqing Gao, Weiwei Liu, Yuan Yang, Jie Jiang, Ying Wang +12 more

Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis

Nature Communications(2021)10.1038/s41467-020-20461-0

N/A

0DataRank · unranked

56 citations

Tsutomu Matsubara, Jaekwon Lee, Cristina Fenollar‐Ferrer, Kyungreem Han, Donghwan Kim +8 more

Pregnane X receptor exacerbates nonalcoholic fatty liver disease accompanied by obesity- and inflammation-prone gut microbiome signature

Biochemical Pharmacology(2021)10.1016/j.bcp.2021.114698

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0DataRank · unranked

51 citations

Sora Choi, Moumita Dutta, Jeffrey O. Asubonteng, Marianne Polunas, Michael Goedken +4 more

Intestinal MYC modulates obesity-related metabolic dysfunction

Nature Metabolism(2021)10.1038/s42255-021-00421-8

N/A

0DataRank · unranked

51 citations

Shoumei Yang, Xuan Wu, Shogo Takahashi, Lulu Sun, Jie Cai +9 more

The pathophysiological function of non-gastrointestinal farnesoid X receptor

Pharmacology & Therapeutics(2021)10.1016/j.pharmthera.2021.107867

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0DataRank · unranked

49 citations

Tingting Yan, Yangliu Xia, Haiping Hao, Guangji Wang, Frank J. Gonzalez +1 more

Withaferin A alleviates fulminant hepatitis by targeting macrophage and NLRP3

Cell Death and Disease(2021)10.1038/s41419-020-03243-w

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0DataRank · unranked

35 citations

Ping Wang, Nana Yan, Frank J. Gonzalez, Tingting Yan, Yangliu Xia

FXR-Deoxycholic Acid-TNF-α Axis Modulates Acetaminophen-Induced Hepatotoxicity

Toxicological Sciences(2021)10.1093/toxsci/kfab027

N/A

0DataRank · unranked

33 citations

Nana Yan, Hong Wang, Tomoki Yagai, Yuhong Luo, Shogo Takahashi +6 more

Feeding-induced resistance to acute lethal sepsis is dependent on hepatic BMAL1 and FXR signalling

Nature Communications(2021)10.1038/s41467-021-22961-z

N/A

0DataRank · unranked

32 citations

Javier Traba, Nathan Richoz, Taylor K. Farley, Stephen R. Brooks, Franziska Petermann +5 more

Withaferin A in the Treatment of Liver Diseases: Progress and Pharmacokinetic Insights

Drug Metabolism and Disposition(2021)10.1124/dmd.121.000455

N/A

0DataRank · unranked

28 citations

Mingrui Yan, Ping Wang, Keisuke Hamada, Nana Yan, Haiping Hao +3 more

Species Differences between Mouse and Human PPARα in Modulating the Hepatocarcinogenic Effects of Perinatal Exposure to a High-Affinity Human PPARα Agonist in Mice

Toxicological Sciences(2021)10.1093/toxsci/kfab068

N/A

0DataRank · unranked

25 citations

Takayuki Koga, Oksana Kosyk, Boo-Hyon Kang, Xiaoyang Zhu, Samuel M. Cohen +7 more

The role of mouse and human peroxisome proliferator-activated receptor-α in modulating the hepatic effects of perfluorooctane sulfonate in mice

Toxicology(2021)10.1016/j.tox.2021.153056

N/A

0DataRank · unranked

22 citations

Laura J Billy, Sue Chang, Frank J. Gonzalez, Andrew D. Patterson, Jeffrey M. Peters +1 more

Intestinal farnesoid X receptor signaling controls hepatic fatty acid oxidation

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids(2021)10.1016/j.bbalip.2021.159089

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14 citations

Yameng Liu, Yuhong Luo, Jie Zhao, Chao Feng, Liming Xue +8 more

Feedback repression of PPARα signaling by Let-7 microRNA

Cell Reports(2021)10.1016/j.celrep.2021.109506

N/A

0DataRank · unranked

19 citations

Tingting Yan, Yuhong Luo, Shogo Takahashi, Daisuke Aibara, Donghwan Kim +5 more

Diminished Hepatocarcinogenesis by a Potent, High-Affinity Human PPARα Agonist in PPARA-Humanized Mice

Toxicological Sciences(2021)10.1093/toxsci/kfab067

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0DataRank · unranked

17 citations

Takayuki Koga, Oksana Kosyk, Boo-Hyon Kang, Xiaoyang Zhu, Samuel M. Cohen +7 more

St. John’s Wort alleviates dextran sodium sulfate‐induced colitis through pregnane X receptor‐dependent NFκB antagonism

The FASEB Journal(2021)10.1096/fj.202001098r

N/A

0DataRank · unranked

17 citations

Yuhong Luo, Yangliu Xia, Keisuke Hamada, Qiong Wang, Nana Yan +6 more

Endothelial Aryl Hydrocarbon Receptor Nuclear Translocator Mediates the Angiogenic Response to Peripheral Ischemia in Mice With Type 2 Diabetes Mellitus

Frontiers in Cell and Developmental Biology(2021)10.3389/fcell.2021.691801

N/A

0DataRank · unranked

10 citations

Mei Zheng, Maura Knapp, Nikola Sladojević, Qin Zhang, Lizhuo Ai +10 more

Mutant Idh2 Cooperates with a NUP98-HOXD13 Fusion to Induce Early Immature Thymocyte Precursor ALL

Cancer Research(2021)10.1158/0008-5472.can-21-1027

N/A

0DataRank · unranked

13 citations

Vijay Negi, Yang Jo Chung, Masahiro Onozawa, Yuelin J. Zhu, Robert L. Walker +9 more

Metabolic map of the antiviral drug podophyllotoxin provides insights into hepatotoxicity

Xenobiotica(2021)10.1080/00498254.2021.1961920

N/A

0DataRank · unranked

10 citations

Xiaoxia Gao, Qiao Wang, Kristopher W. Krausz, Zhong‐Ze Fang, You-Bo Zhang +3 more

Manassantin B attenuates obesity by inhibiting adipogenesis and lipogenesis in an AMPK dependent manner

The FASEB Journal(2021)10.1096/fj.202002126rr

N/A

0DataRank · unranked

7 citations

Gu Qiong, Chanjuan Li, Lulu Sun, Yuhong Luo, Shengheng Yuan +3 more

Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.11.24.469776

N/A

0DataRank · unranked

11 citations

Lulu Sun, Irfan Ullah, Guillaume Beaudoin-Bussières, Sai Priya Anand, Andrew P. Hederman +18 more

Corrigendum to: Tie2-dependent knockout of HIF-1 impairs burn wound vascularization and homing of bone marrow-derived angiogenic cells

Cardiovascular Research(2021)10.1093/cvr/cvab020

N/A

0DataRank · unranked

1 citations

Sergio Rey, X. Zhang, Raul Sebastian, Guy P. Marti, Karen Fox-Talbot +9 more

Gut microbiota-derived bile acids in intestinal immunity, inflammation, and tumorigenesis

Cell Host & Microbe(2022)10.1016/j.chom.2022.02.004

N/A

0DataRank · unranked

817 citations

Lulu Sun, Frank J. Gonzalez, Jie Cai

Gut bacteria alleviate smoking-related NASH by degrading gut nicotine

Nature(2022)10.1038/s41586-022-05299-4

N/A

0DataRank · unranked

216 citations

Lulu Sun, Guangyi Zeng, Zhe Shen, Kai Wang, Limin Yin +19 more

Hepatic cytochrome P450 8B1 and cholic acid potentiate intestinal epithelial injury in colitis by suppressing intestinal stem cell renewal

Cell stem cell(2022)10.1016/j.stem.2022.08.008

N/A

0DataRank · unranked

196 citations

Tingying Jiao, Weiwei Liu, Yuhong Luo, Jue Wang, Xiaozhen Guo +14 more

Microenvironmental ammonia enhances T cell exhaustion in colorectal cancer

Cell Metabolism(2022)10.1016/j.cmet.2022.11.013

N/A

0DataRank · unranked

176 citations

Amanda K. Huber, Rashi Singhal, Navyateja Korimerla, Ryan J. Rebernick, Roshan Kumar +21 more

The role of FXR and TGR5 in reversing and preventing progression of Western diet–induced hepatic steatosis, inflammation, and fibrosis in mice

Journal of Biological Chemistry(2022)10.1016/j.jbc.2022.102530

N/A

0DataRank · unranked

57 citations

Cen Xie, Andrew E. Libby, Suman Ranjit, Jonathan Levi, Komuraiah Myakala +20 more

Epigenetic regulation of white adipose tissue plasticity and energy metabolism by nucleosome binding HMGN proteins

Nature Communications(2022)10.1038/s41467-022-34964-5

N/A

0DataRank · unranked

18 citations

Takashi Furusawa, Alexei Lobanov, Bing He, Cen Xie, Kimia Dadkhah +5 more

Gene repression through epigenetic modulation by PPARA enhances hepatocellular proliferation

iScience(2022)10.1016/j.isci.2022.104196

N/A

0DataRank · unranked

39 citations

Shogo Takahashi, Tomoki Yagai, Donghwan Kim, Chad Brocker, Moshe Levi +3 more

Postprandial Plasma Lipidomics Reveal Specific Alteration of Hepatic-derived Diacylglycerols in Nonalcoholic Fatty Liver Disease

Gastroenterology(2022)10.1053/j.gastro.2022.03.004

N/A

0DataRank · unranked

33 citations

Gil Ben Yakov, Maren C. Podszun, Julian Hercun, Ohad Etzion, Shanna Yang +16 more

Bile acid conjugation deficiency causes hypercholanemia, hyperphagia, islet dysfunction, and gut dysbiosis in mice

Hepatology Communications(2022)10.1002/hep4.2041

N/A

0DataRank · unranked

30 citations

Mikang Lee, Shogo Takahashi, Robert W. Novak, Bipin Rimal, Shannon Boehme +11 more

Withaferin A alleviates ethanol-induced liver injury by inhibiting hepatic lipogenesis

Food and Chemical Toxicology(2022)10.1016/j.fct.2022.112807

N/A

0DataRank · unranked

16 citations

Ping Wang, Yangliu Xia, Nana Yan, Shogo Takahashi, Kristopher W. Krausz +4 more

Pharmacometabolomics reveals urinary diacetylspermine as a biomarker of doxorubicin effectiveness in triple negative breast cancer

npj Precision Oncology(2022)10.1038/s41698-022-00313-4

N/A

0DataRank · unranked

16 citations

Kristopher W. Krausz, Keisuke Hamada, Tiffany H. Dorsey, Stefan Ambs, Shogo Takahashi +2 more

Creatine riboside is a cancer cell–derived metabolite associated with arginine auxotrophy

Journal of Clinical Investigation(2022)10.1172/jci157410

N/A

0DataRank · unranked

12 citations

Leila Toulabi, Takahiro Oike, Yasuyuki Kanke, Daxeshkumar Patel, Takeshi Tada +15 more

Inhibition of estrogen sulfation by Xian-Ling-Gu-Bao capsule

The Journal of Steroid Biochemistry and Molecular Biology(2022)10.1016/j.jsbmb.2022.106182

N/A

0DataRank · unranked

12 citations

Chanjuan Chen, Shuyi Duan, Yang Li, Chuan Li, Xin‐Sheng Yao +4 more

Long non-coding RNA G23Rik attenuates fasting-induced lipid accumulation in mouse liver

Molecular and Cellular Endocrinology(2022)10.1016/j.mce.2022.111722

N/A

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9 citations

Bora Kim, Chad Brocker, Kritika Karri, David J Waxman, Frank J. Gonzalez +1 more

Circadian transcriptional pathway atlas highlights a proteasome switch in intermittent fasting

Cell Reports(2022)10.1016/j.celrep.2022.111547

N/A

0DataRank · unranked

9 citations

Lijun Gong, Siyu Lu, Yiming Zhou, Li Liu, Zhigui Duan +4 more

Bile Acids Are Substrates for Amine N-Acyl Transferase Activity by Bile Salt Hydrolase

Research Square(2022)10.21203/rs.3.rs-2050120/v1

N/A

0DataRank · unranked

20 citations

Bipin Rimal, Stephanie L. Collins, Megan Granda, Imhoi Koo, Sumeet Solanka +15 more

Microenvironmental Ammonia Enhances T cell Exhaustion in Colorectal Cancer

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.05.25.493422

N/A

0DataRank · unranked

9 citations

Amanda K. Huber, Rashi Singhal, Ryan J. Rebernick, Roshan Kumar, Nupur K. Das +17 more

Long non-coding RNA G23Rik attenuates fasting-induced lipid accumulation in the liver

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.04.11.487900

N/A

0DataRank · unranked

0 citations

Bora Kim, Chad Brocker, Kritika Karri, David J Waxman, Frank J. Gonzalez +1 more

Endothelial Aryl Hydrocarbon Receptor Nuclear Translocator Mediates the Angiogenic Response to Peripheral Ischemia in Mice with Type 2 Diabetes Mellitus

Vide Leaf, Hyderabad eBooks(2022)10.37247/pabios2ed.2.22.3

N/A

0DataRank · unranked

0 citations

Mei Zheng, Maura Knapp, Nikola Sladojević, Qin Zhang, Lizhuo Ai +10 more

Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice

Nature Communications(2023)10.1038/s41467-023-37459-z

N/A

0DataRank · unranked

219 citations

Manyun Dai, Ruoyue Huang, Jingyi Duan, Ting Zhang, Weimin Bao +8 more

Bile salt hydrolase in non-enterotoxigenic Bacteroides potentiates colorectal cancer

Nature Communications(2023)10.1038/s41467-023-36089-9

N/A

0DataRank · unranked

120 citations

Yi Zhang, Jie Cai, Bipin Rimal, Edson R. Rocha, James P. Coleman +12 more

Hepatic fibrosis: Targeting peroxisome proliferator-activated receptor alpha from mechanism to medicines

Hepatology(2023)10.1097/hep.0000000000000182

N/A

0DataRank · unranked

50 citations

Fang Wei, Frank J. Gonzalez, Guolin Li, Lijun Gong

Estrogen-Related Receptor Agonism Reverses Mitochondrial Dysfunction and Inflammation in the Aging Kidney

American Journal Of Pathology(2023)10.1016/j.ajpath.2023.07.008

N/A

0DataRank · unranked

42 citations

Komuraiah Myakala, Andrew E. Libby, Ewa Krawczyk, Julia Panov, Bryce A. Jones +22 more

Estrogen genotoxicity causes preferential development of Fuchs endothelial corneal dystrophy in females

Redox Biology(2023)10.1016/j.redox.2023.102986

N/A

0DataRank · unranked

29 citations

Neha Deshpande, Mohit Parekh, Raymond Wong, Shazia Ashraf, Muhammad Zahid +9 more

PPARα activation partially drives NAFLD development in liver-specific Hnf4a-null mice

The Journal of Biochemistry(2023)10.1093/jb/mvad005

N/A

0DataRank · unranked

15 citations

Masayuki Takizawa, Noriyasu Ohshima, Chinatsu Saito, W. Iwasaki, Yuko Nakagawa +9 more

Farnesoid X receptor activation inhibits pancreatic carcinogenesis

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease(2023)10.1016/j.bbadis.2023.166811

N/A

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7 citations

Zhenhua Huang, Yifan Zhang, Haitao Sun, Ulf Hinz, Ulrike Heger +6 more

Keratin 79 is a PPARA target that is highly expressed by liver damage

Biochemical and Biophysical Research Communications(2023)10.1016/j.bbrc.2023.01.071

N/A

0DataRank · unranked

5 citations

In‐Wook Choi, Sang Keun Ha, Frank J. Gonzalez, Donghwan Kim

Structural Optimization and Anticancer Activity of Polo-like Kinase 1 (Plk1) Polo-Box Domain (PBD) Inhibitors and Their Prodrugs

ACS Pharmacology & Translational Science(2023)10.1021/acsptsci.2c00250

N/A

0DataRank · unranked

5 citations

Hobin Lee, Paola Oliva, Klára Kirsch, Bo-Ra Kim, Jong Il Ahn +11 more

The molecular basis of the neutralization breadth of the RBD-specific antibody CoV11

Frontiers in Immunology(2023)10.3389/fimmu.2023.1178355

N/A

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5 citations

Yaozong Chen, Lulu Sun, Mehdi Benlarbi, Shilei Ding, Rohini Manickam +10 more

Changes in the Type 2 diabetes gut mycobiome associate with metformin treatment across populations

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.05.25.542255

N/A

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1 citations

Michelle Pistner Nixon, Justin D. Silverman, Yuhong Luo, Frank J. Gonzalez, Ilze Elbere +5 more

Data from Mutant Idh2 Cooperates with a NUP98-HOXD13 Fusion to Induce Early Immature Thymocyte Precursor ALL

(2023)10.1158/0008-5472.c.6513534.v1

N/A

0DataRank · unranked

0 citations

Vijay Negi, Yang Jo Chung, Masahiro Onozawa, Yuelin J. Zhu, Robert L. Walker +9 more

Bile salt hydrolase catalyses formation of amine-conjugated bile acids

Nature(2024)10.1038/s41586-023-06990-w

N/A

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208 citations

Stephanie L. Collins, Ceylan Tanes, Edson R. Rocha, Megan Granda, Sumeet Solanki +25 more

Inhibition of heme-thiolate monooxygenase CYP1B1 prevents hepatic stellate cell activation and liver fibrosis by accumulating trehalose

Science Translational Medicine(2024)10.1126/scitranslmed.adk8446

N/A

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18 citations

Jong‐Won Kim, Junjie Zhu, Sihan Li, Jiong Yan, Qing Liu +21 more

Amino acid transporter SLC7A5 regulates cell proliferation and secretary cell differentiation and distribution in the mouse intestine

International Journal of Biological Sciences(2024)10.7150/ijbs.94297

N/A

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9 citations

Liezhen Fu, Yijun Su, Zuojia Chen, Zhaoyi Peng, Lulu Sun +6 more

Pregnane X receptor knockout mitigates weight gain and hepatic metabolic dysregulation in female C57BL/6 J mice on a long-term high-fat diet

Biomedicine & Pharmacotherapy(2024)10.1016/j.biopha.2024.116341

N/A

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8 citations

Sora Choi, Prince Neequaye, Mattia A. Mahmoud, Mia Mahmoud, Malvin Ofosu‐Boateng +8 more

Sphingosine Kinase 2 Regulates Aryl Hydrocarbon Receptor Nuclear Translocation and Target Gene Activation

Advanced Science(2024)10.1002/advs.202400794

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7 citations

Imhoi Koo, Daisuke Aibara, Yuan Tian, Iain A. Murray, Stephanie L. Collins +8 more

Molecular targets of PXR-dependent ethanol-induced hepatotoxicity in female mice

Biochemical Pharmacology(2024)10.1016/j.bcp.2024.116416

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6 citations

Malvin Ofosu‐Boateng, Sarah Kim, Daniel Okwudili Nnamani, Mia Mahmoud, Prince Neequaye +6 more

Intestinal stearoyl-coenzyme A desaturase-inhibition improves obesity-associated metabolic disorders

Acta Pharmaceutica Sinica B(2024)10.1016/j.apsb.2024.11.022

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6 citations

Yang Zhang, Zhipeng Zhang, Nana Yan, Vorthon Sawaswong, Lulu Sun +9 more

Associations of chronic liver disease and liver cancer with glyphosate and its metabolites in Thailand

International Journal of Cancer(2024)10.1002/ijc.35282

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4 citations

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Activation of Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ) in Keratinocytes by Endogenous Fatty Acids

Biomolecules(2024)10.3390/biom14060606

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2 citations

Xiaoyang Zhu, Michael G. Borland, Douglas Ralph, Christopher Chiaro, Kristopher W. Krausz +7 more

Human CYP2D6 varies across the estrous cycle in brains of transgenic mice altering drug response

Progress in Neuro-Psychopharmacology and Biological Psychiatry(2024)10.1016/j.pnpbp.2024.111108

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2 citations

Claire McDonald, Fariba Baghai Wadji, Frank J. Gonzalez, Rachel F. Tyndale, Sharon Miksys

Urinary Metabolite Diagnostic and Prognostic Liquid Biopsy Biomarkers of Lung Cancer in Nonsmokers and Tobacco Smokers

Clinical Cancer Research(2024)10.1158/1078-0432.ccr-24-0637

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2 citations

Takeshi Tada, Daxesh P. Patel, Sharon R. Pine, Mohammed Khan, Takahiro Oike +10 more

Microbial riboflavin inhibits ceramide synthase 3 to lower ceramide (d18:1/26:0) and delay colorectal cancer progression

Cell Metabolism(2025)10.1016/j.cmet.2025.06.002

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19 citations

Yi Zhang, Bora Kim, Guangyi Zeng, Pengcheng Wang, Weike Shaoyong +23 more

Evaluation of the Ellman’s Reagent Protocol for Free Sulfhydryls Under Protein Denaturing Conditions

Analytica—A Journal of Analytical Chemistry and Chemical Analysis(2025)10.3390/analytica6020018

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7 citations

Frank J. Gonzalez, Maxine L. Marano, Megha D. Salecha, Joseph E. Reiner, Gregory A. Caputo +1 more

Role of metabolic nuclear receptors in acute liver injury and drug-induced hepatotoxicity

Pharmacological Research(2025)10.1016/j.phrs.2025.107942

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7 citations

Nana Yan, Frank J. Gonzalez, Haiping Hao, Tingting Yan, Lichen Nie

Blockade of the estrogen receptor alpha–pregnane X receptor axis protects ovariectomized mice against ethanol-induced hepatotoxicity

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.110238

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1 citations

Malvin Ofosu‐Boateng, Daniel Okwudili Nnamani, Lidya H Gebreyesus, Nour Yadak, Kusum K. Kharbanda +3 more

Targeting the peroxisomal FASN-ACOX2 axis to modulate energy homeostasis: therapeutic potential and challenges

Targetome(2025)10.48130/targetome-0025-0006

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1 citations

Yannan Fang, Yang Zhang, Frank J. Gonzalez, Tingting Yan, Xi Xu

Differential hepatic activation of mouse and human peroxisome proliferator-activated receptor-α by perfluorohexane sulfonate

Toxicological Sciences(2025)10.1093/toxsci/kfaf026

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2 citations

Annalee M Schmidt, Kyle J Oldro, Xiaoyang Zhu, Angelina R Kramer, Sarah R Hamilton +11 more

Human PXR Signaling Exacerbates Ethanol-induced Liver Injury in Females: Evidence From Mouse Models and Human Alcohol-associated Liver Disease Cohorts

Cellular and Molecular Gastroenterology and Hepatology(2025)10.1016/j.jcmgh.2025.101589

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0 citations

Sora Choi, Sarah Kim, Elizabeth Twum, Daniel Okwudili Nnamani, Lidya H Gebreyesus +8 more

Role of the xenobiotic-activated pregnane X receptor in type 1 and type 2 diabetes in male mice

Biochemical Pharmacology(2025)10.1016/j.bcp.2025.117482

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0 citations

Sora Choi, Malvin Ofosu‐Boateng, Lidya H Gebreyesus, Elizabeth Twum, Marianne Polunas +8 more

Comprehensive analysis of transcriptomics and metabolomics to understand triptolide-induced liver injury in mice

Toxicology Letters(2020)10.1016/j.toxlet.2020.08.007

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Human CYP2D6 Is Functional in Brain In Vivo: Evidence from Humanized CYP2D6 Transgenic Mice

Molecular Neurobiology(2020)10.1007/s12035-020-01896-4

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32 citations

Marlaina R. Stocco, Sharon Miksys, Frank J. Gonzalez, Rachel F. Tyndale, Edgor Cole Tolledo