Dhirendra K. Simanshu

Frederick National Laboratory for Cancer Research

Biochemistry, Genetics and Molecular BiologyMaterials Science

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 32 papers. Top paper: “RAS internal tandem duplication disrupts GTPase-activating protein (GAP) binding to activate oncogenic signaling”.

RAS internal tandem duplication disrupts GTPase-activating protein (GAP) binding to activate oncogenic signaling

Journal of Biological Chemistry(2020)10.1074/jbc.ra119.011080

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0.622DataRank · unranked

13 citations

Thomas J. Turbyville, Srisathiyanarayanan Dharmaiah, Megan Rigby, Rendong Yang, Ting-You Wang +11 more

Biophysical and structural analysis of KRAS switch-II pocket inhibitors reveals allele-specific binding constraints

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.110331

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0.540DataRank · unranked

15 citations

Albert H. Chan, Dana Rabara, Monalisa Swain, Erik K. Larsen, Marcin Dyba +11 more

Membrane interactions of the globular domain and the hypervariable region of KRAS4b define its unique diffusion behavior

eLife(2020)10.7554/elife.47654

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0DataRank · unranked

29 citations

De Chen, Yue Yang, Prabhakar R. Gudla, John Columbus, Karen M. Worthy +13 more

KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation

Nature Communications(2021)10.1038/s41467-021-21422-x

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0DataRank · unranked

253 citations

Albert H. Chan, Lucy C. Young, Lakshman Bindu, Chris Neale, Simon Messing +9 more

The tumor suppressor activity of DLC1 requires the interaction of its START domain with Phosphatidylserine, PLCD1, and Caveolin-1

Molecular Cancer(2021)10.1186/s12943-021-01439-y

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0DataRank · unranked

27 citations

Dunrui Wang, Xiaolan Qian, Velayoudame Parthibane, Dhirendra K. Simanshu, Jairaj Acharya +2 more

RAS interaction with Sin1 is dispensable for mTORC2 assembly and activity

Proceedings of the National Academy of Sciences(2021)10.1073/pnas.2103261118

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0DataRank · unranked

39 citations

Srisathiyanarayanan Dharmaiah, Matthew J. Sale, Simon Messing, Gabrielle Rizzuto, Antonio Cuevas-Navarro +7 more

Purification of Cytosolic Phospholipase A2α C2-domain after Expression in Soluble Form in Escherichia coli

BIO-PROTOCOL(2021)10.21769/bioprotoc.3906

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0DataRank · unranked

1 citations

Yong‐Guang Gao, Dhirendra K. Simanshu, Daniel Stephenson, Ngoc Vu, Lucy Malinina +4 more

Machine learning–driven multiscale modeling reveals lipid-dependent dynamics of RAS signaling proteins

Proceedings of the National Academy of Sciences(2022)10.1073/pnas.2113297119

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0DataRank · unranked

87 citations

Chris Neale, Timothy S. Carpenter, Rebika Shrestha, César A. López, Timothy H. Tran +37 more

A Structure is Worth a Thousand Words: New Insights for RAS and RAF Regulation

Cancer Discovery(2022)10.1158/2159-8290.cd-21-1494

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0DataRank · unranked

72 citations

Deborah K. Morrison, Dhirendra K. Simanshu

Structure of the SHOC2–MRAS–PP1C complex provides insights into RAF activation and Noonan syndrome

Nature Structural & Molecular Biology(2022)10.1038/s41594-022-00841-4

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0DataRank · unranked

54 citations

Patrick Alexander, Kelly Snead, Nicole Hartig, Matthew Drew, Simon Messing +8 more

Exploring CRD mobility during RAS/RAF engagement at the membrane

Biophysical Journal(2022)10.1016/j.bpj.2022.06.035

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0DataRank · unranked

28 citations

César A. López, Chris Neale, Que N. Van, Timothy S. Carpenter, Francesco Di Natale +25 more

Insights into the Cross Talk between Effector and Allosteric Lobes of KRAS from Methyl Conformational Dynamics

Journal of the American Chemical Society(2022)10.1021/jacs.2c00007

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0DataRank · unranked

27 citations

Srisathiyanarayanan Dharmaiah, Troy Taylor, Simon Messing, William Gillette, Dominic Esposito +6 more

Structure of the SHOC2–MRAS–PP1C complex provides insights into RAF activation and Noonan syndrome

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.05.10.491335

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0DataRank · unranked

4 citations

Patrick Alexander, Kelly Snead, Nicole Hartig, Matthew Drew, Simon Messing +8 more

A cancer-associated K-RAS mutant that preferentially binds GDP displays gain-of-function and atypical signaling

Research Square(2022)10.21203/rs.3.rs-1521657/v1

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0DataRank · unranked

1 citations

Tatu Pantsar, Alex G. Papageorge1, Brajendra K. Tripathi, Beatriz Sánchez‐Solana, Marian E. Durkin +8 more

Allosteric regulation of switch-II controls K-Ras oncogenicity

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.09.20.508702

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0DataRank · unranked

1 citations

Timothy H. Tran, Bethany Hunt, Rebecca Agnor, Christian W. Johnson, Timothy J. Waybright +5 more

Ras-dependent RAF-MAPK hyperactivation by pathogenic RIT1 is a therapeutic target in Noonan syndrome-associated cardiac hypertrophy

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.11.02.514888

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0DataRank · unranked

1 citations

Morgan E. Wagner, Richard Van, Monalisa Swain, Madeline R. Allison, Alice Cheng +7 more

Consensus on the RAS dimerization hypothesis: Strong evidence for lipid-mediated clustering but not for G-domain-mediated interactions

Molecular Cell(2023)10.1016/j.molcel.2023.03.008

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0DataRank · unranked

55 citations

Mark R. Philips, John F. Hancock, Dhirendra K. Simanshu

RAS-dependent RAF-MAPK hyperactivation by pathogenic RIT1 is a therapeutic target in Noonan syndrome–associated cardiac hypertrophy

Science Advances(2023)10.1126/sciadv.adf4766

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0DataRank · unranked

25 citations

Morgan E. Wagner, Richard Van, Monalisa Swain, Stephanie Mo, John Columbus +10 more

Reduced dynamic complexity allows structure elucidation of an excited state of KRASG13D

Communications Biology(2023)10.1038/s42003-023-04960-6

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0DataRank · unranked

16 citations

Albert H. Chan, Srisathiyanarayanan Dharmaiah, Charles D. Schwieters, Timothy H. Tran, Troy Taylor +7 more

Allosteric Regulation of Switch-II Domain Controls KRAS Oncogenicity

Cancer Research(2023)10.1158/0008-5472.can-22-3210

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0DataRank · unranked

15 citations

Timothy H. Tran, Bethany Hunt, Rebecca Agnor, Christian W. Johnson, Bing Shui +6 more

The ribosomal S6 kinase 2 (RSK2)–SPRED2 complex regulates the phosphorylation of RSK substrates and MAPK signaling

Journal of Biological Chemistry(2023)10.1016/j.jbc.2023.104789

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0DataRank · unranked

13 citations

Daniel A. Bonsor, Matthew J. Sale, Anatoly Urisman, Jennifer Mehalko, Miranda Cabanski-Dunning +4 more

RAS and SHOC2 Roles in RAF Activation and Therapeutic Considerations

Annual Review of Cancer Biology(2023)10.1146/annurev-cancerbio-062822-030450

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0DataRank · unranked

12 citations

Dhirendra K. Simanshu, Daniel A. Bonsor

Structural insights into the role of SHOC2‐MRAS‐PP1C complex in RAF activation

FEBS Journal(2023)10.1111/febs.16800

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0DataRank · unranked

8 citations

Dhirendra K. Simanshu, Daniel A. Bonsor

Comparative analysis of KRAS4a and KRAS4b splice variants reveals distinctive structural and functional properties

Science Advances(2024)10.1126/sciadv.adj4137

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0DataRank · unranked

38 citations

Timothy H. Tran, Megan Rigby, Ming Yi, Srisathiyanarayanan Dharmaiah, Timothy J. Waybright +12 more

Functional and structural insights into RAS effector proteins

Molecular Cell(2024)10.1016/j.molcel.2024.06.027

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0DataRank · unranked

23 citations

Dhirendra K. Simanshu, Pau Castel, Alessandro M. Mozzarelli

Structural dynamics of RAF1-HSP90-CDC37 and HSP90 complexes reveal asymmetric client interactions and key structural elements

Communications Biology(2024)10.1038/s42003-024-05959-3

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0DataRank · unranked

19 citations

Mayukh Chakrabarti, Gülçin Gülten, Joseph Finney, Carissa Grose, Tara Fox +7 more

Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activity

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.10.22.618529

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0DataRank · unranked

9 citations

Julien Dilly, Shengwu Liu, Eejung Kim, Yuemin Bian, Srisathiyanarayanan Dharmaiah +24 more

Structural insights into isoform-specific RAS-PI3Kα interactions and the role of RAS in PI3Kα activation

Nature Communications(2025)10.1038/s41467-024-55766-x

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0DataRank · unranked

32 citations

Wupeng Yan, Simon Messing, William Gillette, Takashi Tsuji, Mitsuhiro Yamaguchi +7 more

Structural basis for LZTR1 recognition of RAS GTPases for degradation

Science(2025)10.1126/science.adv7088

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0DataRank · unranked

11 citations

Daniel A. Bonsor, Stephanie Mo, Alvaro Fernandez-Cabrera, Albert H. Chan, Simon D. Messing +7 more

Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR

Cell Reports(2020)10.1016/j.celrep.2020.107909

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0DataRank · unranked

69 citations

Evan Markegard, Srisathiyanarayanan Dharmaiah, Anatoly Urisman, Matthew Drew, Dominic Esposito +5 more

Blocking C-terminal processing of KRAS4b via a direct covalent attack on the CaaX-box cysteine

Proceedings of the National Academy of Sciences(2025)10.1073/pnas.2410766122

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0DataRank · unranked

6 citations

Yue Yang, Alok K. Sharma, David M. Turner, Caroline J. DeHart, Hazem Abdelkarim +29 more

Uncovering a membrane-distal conformation of KRAS available to recruit RAF to the plasma membrane

Proceedings of the National Academy of Sciences(2020)10.1073/pnas.2006504117

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0DataRank · unranked

58 citations

César A. López, Marco Tonelli, Troy Taylor, Ben Niu, Christopher B. Stanley +24 more