John Danesh

Also affiliated with University of Cambridge, Wellcome Sanger Institute, British Heart Foundation, National Institute for Health and Care Research, Cambridge University Health Partners, Health Data Research UK, University of Birmingham

Biochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 1%percentile

44.3Author DataRank

Indexed papers

10in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 10 indexed papers attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

The highest-impact dataset this researcher has shared, ranked by DataRank — the single contribution doing the most to lift their data-sharing standing.

Analysis of protein-coding genetic variation in 60,706 humans

Nature(2016)10.1038/nature19057

Top 1%

13.0DataRank

Top 1%10410 citations

Monkol Lek, Konrad J. Karczewski, Eric V. Minikel, Kaitlin E. Samocha, Iain Mathieson +76 more

Papers

Driven by 58 papers — median percentile 78. Top paper: “Analysis of protein-coding genetic variation in 60,706 humans”.

Analysis of protein-coding genetic variation in 60,706 humans

Nature(2016)10.1038/nature19057

Top 1%

13.0DataRank

Top 1%10410 citations

Monkol Lek, Konrad J. Karczewski, Eric V. Minikel, Kaitlin E. Samocha, Iain Mathieson +76 more

UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age

PLOS Medicine(2015)10.1371/journal.pmed.1001779

Top 1%

12.8DataRank

Top 1%13532 citations

John Gallacher, Valerie Beral, Paul Burton, John Danesh, Paul Downey +17 more

A road map for efficient and reliable human genome epidemiology

Nature Genetics(2006)10.1038/ng0106-3

Top 1%

10.4DataRank

Top 1%244 citations

John P. A. Ioannidis, Marta Gwinn, Julian Little, Julian P. T. Higgins, Jonine L. Bernstein +38 more

Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals

Nature Metabolism(2020)10.1038/s42255-020-00287-2

N/A

10.0DataRank · unranked

782 citations

Stefan Gustafsson, Qin Wang, Daniel Hvidberg Hansen, Åsa K. Hedman, Andrew J. Schork +78 more

A genomic mutational constraint map using variation in 76,156 human genomes

Nature(2023)10.1038/s41586-023-06045-0

N/A

9.6DataRank · unranked

1369 citations

Laurent C. Francioli, Julia K. Goodrich, Ryan L. Collins, Masahiro Kanai, Qingbo S. Wang +95 more

Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations

Cell(2020)10.1016/j.cell.2020.06.045

N/A

8.3DataRank · unranked

739 citations

Laura M. Raffield, Abdou Mousas, Saori Sakaue, Jennifer E. Huffman, Arden Moscati +95 more

RETRACTED: Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses

The Lancet Diabetes & Endocrinology(2021)10.1016/s2213-8587(21)00263-1

N/A

8.0DataRank · unranked

190 citations

Stephen Kaptoge, Shoaib Afzal, Tao Jiang, Dipender Gill, Thomas E. Gundersen +81 more

Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants

Nature Genetics(2022)10.1038/s41588-022-01233-6

N/A

7.7DataRank · unranked

721 citations

Tao Jiang, Anuj Goel, Stavroula Kanoni, Brooke N. Wolford, Deepak Atri +92 more

A structural variation reference for medical and population genetics

Nature(2020)10.1038/s41586-020-2287-8

Top 3%

6.7DataRank

Top 3%1180 citations

Harrison Brand, Konrad J. Karczewski, Xuefang Zhao, Jessica Alföldi, Laurent C. Francioli +201 more

Life expectancy associated with different ages at diagnosis of type 2 diabetes in high-income countries: 23 million person-years of observation

The Lancet Diabetes & Endocrinology(2023)10.1016/s2213-8587(23)00223-1

N/A

6.6DataRank · unranked

215 citations

SRK Seshasai, Liang Sun, Mark Walker, Tom Bolton, Sue Spackman +95 more

Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes

Nature Communications(2020)10.1038/s41467-019-12438-5

N/A

5.6DataRank · unranked

143 citations

James Zou, Beryl B. Cummings, Jessica Alföldi, Laurent C. Francioli, Laura D. Gauthier +174 more

Characterising the loss-of-function impact of 5’ untranslated region variants in 15,708 individuals

Nature Communications(2020)10.1038/s41467-019-10717-9

N/A

5.2DataRank · unranked

191 citations

Konrad J. Karczewski, Xiaolei Zhang, Sonia Chothani, Miriam J. Smith, D. Gareth Evans +181 more

The effect of LRRK2 loss-of-function variants in humans

Nature Medicine(2020)10.1038/s41591-020-0893-5

N/A

4.9DataRank · unranked

114 citations

Irina M. Armean, Aaron Kleinman, Jamie L. Marshall, Eric V. Minikel, Julia K. Goodrich +214 more

The Emergence of Networks in Human Genome Epidemiology

Epidemiology(2007)10.1097/01.ede.0000249540.17855.b7

N/A

4.3DataRank · unranked

92 citations

Muin J. Khoury, Thomas R. O??Brien, Julian Little, Julian P. T. Higgins, Jonine L. Bernstein +35 more

A Network of Investigator Networks in Human Genome Epidemiology

American Journal of Epidemiology(2005)10.1093/aje/kwi201

N/A

4.2DataRank · unranked

118 citations

John Danesh, Siobhan Dolan, Patricia Hartge, Christopher A. Haiman, Peter Inskip +23 more

Rare and common genetic determinants of metabolic individuality and their effects on human health

Nature Medicine(2022)10.1038/s41591-022-02046-0

N/A

4.1DataRank · unranked

157 citations

Isobel D. Stewart, Victoria P. W. Au Yeung, Maik Pietzner, Johannes Raffler, Maria A. Wörheide +31 more

Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease

Nature Communications(2018)10.1038/s41467-018-03911-8

N/A

3.1DataRank · unranked

104 citations

Amit V. Khera, Mark Chaffin, Derek Klarin, Pradeep Natarajan, Krishna Aragam +43 more

The mutational constraint spectrum quantified from variation in 141,456 humans

Nature(2020)10.1038/s41586-020-2308-7

N/A

1.4DataRank · unranked

9958 citations

Laurent C. Francioli, Grace Tiao, Beryl B. Cummings, Jessica Alföldi, Qingbo S. Wang +187 more

Turning the Pump Handle: Evolving Methods for Integrating the Evidence on Gene-Disease Association

American Journal of Epidemiology(2007)10.1093/aje/kwm248

N/A

1.3DataRank · unranked

27 citations

Melissa Bondy, B. Anagnostelis, Rory Collins, C. Dezateux, S. J. Lewis +32 more

Rare coding variants in 35 genes associate with circulating lipid levels—A multi-ancestry analysis of 170,000 exomes

The American Journal of Human Genetics(2021)10.1016/j.ajhg.2021.11.021

N/A

1.3DataRank · unranked

70 citations

Peter Dornbos, Mark Chaffin, Dajiang J. Liu, Minxian Wang, Margaret Sunitha Selvaraj +95 more

ACE inhibition and cardiometabolic risk factors, lung ACE2 and TMPRSS2 gene expression, and plasma ACE2 levels: a Mendelian randomization study

Royal Society Open Science(2020)10.1098/rsos.200958

N/A

1.2DataRank · unranked

19 citations

Marios Arvanitis, Paul Carter, Ana I. Hernández Cordero, Brian Jo, Ville Karhunen +28 more

Defining the role of common variation in the genomic and biological architecture of adult human height

Nature Genetics(2014)10.1038/ng.3097

N/A

1.1DataRank · unranked

2093 citations

Emilio Rodríguez-Ruiz, The PAGE Consortium, Diana O. Perkins, Tonu Esko, Jian Yang +479 more

The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease

Cell(2016)10.1016/j.cell.2016.10.042

N/A

1.1DataRank · unranked

1405 citations

Heather Elding, Tao Jiang, Dave Allen, Dace Ruklisa, Alice L. Mann +78 more

The genetic architecture of type 2 diabetes

Nature(2016)10.1038/nature18642

N/A

1.1DataRank · unranked

1106 citations

Menachem Fromer, Tanya M. Teslovich, Anubha Mahajan, Vineeta Agarwala, Kyle J. Gaulton +334 more

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

Nature Genetics(2014)10.1038/ng.2897

N/A

1.0DataRank · unranked

1086 citations

Anubha Mahajan, Min Jin Go, Weihua Zhang, Jennifer E Below, Kyle J Gaulton +327 more

The Polygenic and Monogenic Basis of Blood Traits and Diseases

Cell(2020)10.1016/j.cell.2020.08.008

N/A

0.988DataRank · unranked

722 citations

Erik L. Bao, Parsa Akbari, Caleb A. Lareau, Abdou Mousas, Tao Jiang +95 more

Transcript expression-aware annotation improves rare variant interpretation

Nature(2020)10.1038/s41586-020-2329-2

N/A

0.796DataRank · unranked

201 citations

Konrad J. Karczewski, Ditte Demontis, Eleanor G. Seaby, Nicholas A. Watts, Moriel Singer-Berk +177 more

Genome-Wide Association Study Identifies a Novel Locus Contributing to Type 2 Diabetes Susceptibility in Sikhs of Punjabi Origin From India

Diabetes(2013)10.2337/db12-1077

N/A

0.787DataRank · unranked

189 citations

Danish Saleheen, Latonya F. Been, Martha L. Garavito, Timothy Braun, Andrew Bjonnes +43 more

Evaluating drug targets through human loss-of-function genetic variation

Nature(2020)10.1038/s41586-020-2267-z

N/A

0.779DataRank · unranked

179 citations

Konrad J. Karczewski, Hilary C. Martin, Beryl B. Cummings, Nicola Whiffin, Daniel R. Rhodes +150 more

Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses

The Lancet Diabetes & Endocrinology(2023)10.1016/s2213-8587(23)00287-5

N/A

0.654DataRank · unranked

77 citations

Stephen Kaptoge, Shoaib Afzal, Tao Jiang, Dipender Gill, Thomas E. Gundersen +81 more

Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants

medRxiv(2021)10.1101/2021.05.24.21257377

N/A

0.637DataRank · unranked

69 citations

Tao Jiang, Anuj Goel, Stavroula Kanoni, Brooke N. Wolford, Elle M. Weeks +87 more

Genome-wide meta-analyses of restless legs syndrome yield insights into genetic architecture, disease biology and risk prediction

Nature Genetics(2024)10.1038/s41588-024-01763-1

N/A

0.609DataRank · unranked

57 citations

Chen Zhao, Steven Bell, Maria Didriksen, Muhammad Sulaman Nawaz, Nathalie Schandra +65 more

Contribution of Common Genetic Variants to Risk of Early-Onset Ischemic Stroke

Neurology(2022)10.1212/wnl.0000000000201006

N/A

0.546DataRank · unranked

37 citations

Huichun Xu, Brady Gaynor, John W. Cole, Kristiina Rannikmäe, Tara M. Stanne +95 more

Rare coding variants in 35 genes associate with circulating lipid levels – a multi-ancestry analysis of 170,000 exomes

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.12.22.423783

N/A

0.534DataRank · unranked

11 citations

Peter Dornbos, Mark Chaffin, Dajiang J. Liu, Minxian X. Wang, Margaret Sunitha Selvaraj +95 more

An atlas of genetic scores to predict multi-omic traits

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.04.17.488593

Top 40%

0.473DataRank

Top 40%8 citations

Scott C. Ritchie, Yujian Liang, Paul R. H. J. Timmers, Maik Pietzner, Loïc Lannelongue +31 more

Elucidating mechanisms of genetic cross-disease associations at the PROCR vascular disease locus

Nature Communications(2022)10.1038/s41467-022-28729-3

N/A

0.470DataRank · unranked

22 citations

Lingyan Chen, Paulina J. Stanczyk, Joanna M. M. Howson, Amy M. Mason, Stephen Burgess +91 more

Cardiac Troponins and Cardiovascular Disease Risk Prediction

Journal of the American College of Cardiology(2025)10.1016/j.jacc.2025.02.016

N/A

0.442DataRank · unranked

18 citations

Spencer Keene, Lisa Pennells, Stephen Kaptoge, Dorien M Kimenai, Matthew R. Walker +57 more

Exploring penetrance of clinically relevant variants in over 800,000 humans from the Genome Aggregation Database

Nature Communications(2025)10.1038/s41467-025-61698-x

Top 44%

0.417DataRank

Top 44%14 citations

Moriel Singer‐Berk, Sarah L. Stenton, Julia K. Goodrich, Michael W. Wilson, Jonah Einson +95 more

Large-scale exome array summary statistics resources for glycemic traits to aid effector gene prioritization

Wellcome Open Research(2023)10.12688/wellcomeopenres.18754.1

N/A

0.357DataRank · unranked

7 citations

Natasha Hui Jin Ng, Juan Fernandez, Rebecca S. Fine, Eleanor Wheeler, Jennifer Wessel +95 more

Genetic Analyses of Blood Cell Structure for Biological and Pharmacological Inference

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.01.30.927483

N/A

0.345DataRank · unranked

9 citations

Dragana Vuckovic, Tao Jiang, Kousik Kundu, Roman Kreuzhuber, Erik L. Bao +28 more

Mendelian randomisation identifies alternative splicing of the FAS death receptor as a mediator of severe COVID-19

medRxiv(2021)10.1101/2021.04.01.21254789

N/A

0.345DataRank · unranked

9 citations

Jack Gisby, Artemis Papadaki, Marisa D. Muckian, Erin Macdonald-Dunlop, Jing Hua Zhao +64 more

Neurocognitive trajectory and proteomic signature of inherited risk for Alzheimer’s disease

PLoS Genetics(2022)10.1371/journal.pgen.1010294

N/A

0.292DataRank · unranked

6 citations

Mark Chaffin, Sohail Zahid, Scott C. Ritchie, Jerome I. Rotter, Stephen S. Rich +11 more

The emergence of networks in human genome epidemiology: challenges and opportunities

Human Genome Epidemiology, 2nd Edition(2009)10.1093/acprof:oso/9780195398441.003.0007

Top 57%

0.276DataRank

Top 57%5 citations

Muin J. Khoury, Marta Gwinn, Julian Little, Julian P. T. Higgins, Jonine L. Bernstein +31 more

UK Longitudinal Linkage Collaboration (UK LLC): The National Trusted Research Environment for Longitudinal Research

International Journal for Population Data Science(2025)10.23889/ijpds.v10i1.2468

Top 60%

0.242DataRank

Top 60%3 citations

Katharine Evans, Emma L. Turner, Robin Flaig, Jacqui Oakley, Kirsteen Campbell +90 more

Misexpression of inactive genes in whole blood is associated with nearby rare structural variants

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.11.17.567537

N/A

0.241DataRank · unranked

4 citations

Katie L. Burnham, Niek de Klein, Manuel Tardáguila, Brittany Howell, Klaudia Walter +20 more

Investigating Genetic and Other Determinants of First-Onset Myocardial Infarction in Malaysia: Protocol for the Malaysian Acute Vascular Events Risk Study

JMIR Research Protocols(2021)10.2196/31885

N/A

0.165DataRank · unranked

2 citations

Mohd Fairulnizal Md Noh, Sophia Rasheeqa Ismail, Kim Robin van Daalen, Puteri Sofia Nadira Megat Kamaruddin, Siti Hafizah Zulkiply +43 more

Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents

UNC Libraries(2020)10.17615/gvf2-mw33

N/A

0DataRank · unranked

0 citations

Simon G. Thompson, Susan M. Gapstur, Eleni Sofi Anopoulou, Linda M. O’Keeffe, Jane Green +56 more

Association of Cardiometabolic Multimorbidity With Mortality

UNC Libraries(2021)10.17615/8ybd-8r67

N/A

0DataRank · unranked

0 citations

Mark Woodward, Aulikki Nissinen, Maurizio Trevisan, Elizabeth Barr, Stephen Kaptoge +83 more

Improving reporting standards for polygenic scores in risk prediction studies

medRxiv(2020)10.1101/2020.04.23.20077099

N/A

0DataRank · unranked

55 citations

Samuel A. Lambert, Cecelia P. Tamburro, Michael A. Iacocca, Jack W. O’Sullivan, Catherine H. Sillari +28 more

Misexpression of inactive genes in whole blood is associated with nearby rare structural variants

The American Journal of Human Genetics(2024)10.1016/j.ajhg.2024.06.017

N/A

0DataRank · unranked

4 citations

Katie L. Burnham, Niek de Klein, Manuel Tardáguila, Brittany Howell, Klaudia Walter +20 more

Integrated clinical risk prediction of type 2 diabetes with a multifactorial polygenic risk score

medRxiv(2024)10.1101/2024.08.22.24312440

N/A

0DataRank · unranked

6 citations

Henry J. Taylor, Yujian Liang, Hasanga D. Manikpurage, Lisa Pennells, Carles Foguet +19 more

Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders

UNC Libraries(2024)10.17615/4nb8-at41

N/A

0DataRank · unranked

0 citations

David Curtis, Jennifer Sambrook, Robin Murray, David St Clair, Trevor Cole +54 more

Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction

UNC Libraries(2020)10.17615/pc2a-ev84

N/A

0DataRank · unranked

0 citations

Jeanette Erdmann, Paul L. Auer, Robert Roberts, John Danesh, Deborah Farlow +27 more

Analyzing human knockouts to validate GPR151 as a therapeutic target for reduction of body mass index

PLoS Genetics(2022)10.1371/journal.pgen.1010093

N/A

0DataRank · unranked

3 citations

John Dominy, Shareef Khalid, Linh Vong, Shari L. Caplan, Treeve Currie +21 more

Pleiotropic heritability quantifies the shared genetic variance of common diseases

medRxiv(2025)10.1101/2025.06.10.25329261

N/A

0DataRank · unranked

2 citations

Benjamin J. Strober, Kangcheng Hou, Gaspard Kerner, John Danesh, Steven Gazal +5 more

A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease

PLoS Genetics(2020)10.1371/journal.pgen.1008629

N/A

0DataRank · unranked

169 citations

Mary E. Haas, Amit V. Khera, Krishna G. Aragam, Mark Chaffin, Derek Klarin +37 more

A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease.

Apollo (University of Cambridge)(2020)10.17863/cam.52580

N/A

0DataRank · unranked

0 citations

Mary E. Haas, Amit V. Khera, Krishna G. Aragam, Mark Chaffin, Derek Klarin +37 more

Analyzing human knockouts to validate GPR151 as a therapeutic target for reduction of body mass index

medRxiv(2021)10.1101/2021.10.21.21264378

N/A

0DataRank · unranked

0 citations

John Dominy, Shareef Khalid, Linh Vong, Shari L. Caplan, Treeve Currie +22 more

John Danesh

Indexed papers

Top data-sharing exemplar

Papers