Eric Vallabh Minikel

Also affiliated with Cambridge Health Alliance, Harvard University, University of Massachusetts Chan Medical School, Massachusetts General Hospital, Prion Alliance, UMass Memorial Medical Center

Biochemistry, Genetics and Molecular BiologyNeuroscienceNursing

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 1%percentile

19.7Author DataRank

Indexed papers

4in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 4 indexed papers attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

The highest-impact dataset this researcher has shared, ranked by DataRank — the single contribution doing the most to lift their data-sharing standing.

Analysis of protein-coding genetic variation in 60,706 humans

Nature(2016)10.1038/nature19057

Top 1%

13.0DataRank

Top 1%10410 citations

Monkol Lek, Konrad J. Karczewski, Eric V. Minikel, Kaitlin E. Samocha, Iain Mathieson +76 more

Papers

Driven by 36 papers — median percentile 97. Top paper: “Analysis of protein-coding genetic variation in 60,706 humans”.

Analysis of protein-coding genetic variation in 60,706 humans

Nature(2016)10.1038/nature19057

Top 1%

13.0DataRank

Top 1%10410 citations

Monkol Lek, Konrad J. Karczewski, Eric V. Minikel, Kaitlin E. Samocha, Iain Mathieson +76 more

A structural variation reference for medical and population genetics

Nature(2020)10.1038/s41586-020-2287-8

Top 3%

6.7DataRank

Top 3%1180 citations

Harrison Brand, Konrad J. Karczewski, Xuefang Zhao, Jessica Alföldi, Laurent C. Francioli +201 more

Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes

Nature Communications(2020)10.1038/s41467-019-12438-5

N/A

5.6DataRank · unranked

143 citations

James Zou, Beryl B. Cummings, Jessica Alföldi, Laurent C. Francioli, Laura D. Gauthier +174 more

Characterising the loss-of-function impact of 5’ untranslated region variants in 15,708 individuals

Nature Communications(2020)10.1038/s41467-019-10717-9

N/A

5.2DataRank · unranked

191 citations

Konrad J. Karczewski, Xiaolei Zhang, Sonia Chothani, Miriam J. Smith, D. Gareth Evans +181 more

The effect of LRRK2 loss-of-function variants in humans

Nature Medicine(2020)10.1038/s41591-020-0893-5

N/A

4.9DataRank · unranked

114 citations

Irina M. Armean, Aaron Kleinman, Jamie L. Marshall, Eric V. Minikel, Julia K. Goodrich +214 more

Cerebrospinal fluid and plasma biomarkers in individuals at risk for genetic prion disease

BMC Medicine(2020)10.1186/s12916-020-01608-8

N/A

1.9DataRank · unranked

57 citations

Eric Vallabh Minikel, Victoria J. Williams, Becky C. Carlyle, Alison J. McManus, Chase Wennick +13 more

The mutational constraint spectrum quantified from variation in 141,456 humans

Nature(2020)10.1038/s41586-020-2308-7

N/A

1.4DataRank · unranked

9958 citations

Laurent C. Francioli, Grace Tiao, Beryl B. Cummings, Jessica Alföldi, Qingbo S. Wang +187 more

Human loss-of-function variants suggest that partial LRRK2 inhibition is a safe therapeutic strategy for Parkinson’s disease

bioRxiv (Cold Spring Harbor Laboratory)(2019)10.1101/561472

N/A

0.977DataRank · unranked

17 citations

Irina M. Armean, Aaron Kleinman, Jamie L. Marshall, Eric Vallabh Minikel, Konrad J. Karczewski +35 more

Multimodal small-molecule screening for human prion protein binders

Journal of Biological Chemistry(2020)10.1074/jbc.ra120.014905

N/A

0.934DataRank · unranked

29 citations

Michael F. Mesleh, Dominick Casalena, Sonia M. Vallabh, Jayme L. Dahlin, Alison Leed +21 more

Effect of predicted protein-truncating genetic variants on the human transcriptome

Science(2015)10.1126/science.1261877

N/A

0.877DataRank · unranked

345 citations

Matti Pirinen, Donald F. Conrad, Monkol Lek, Emily K. Tsang, Konrad J. Karczewski +206 more

Refining the impact of genetic evidence on clinical success

Nature(2024)10.1038/s41586-024-07316-0

N/A

0.862DataRank · unranked

312 citations

Jeffery L. Painter, Coco Chengliang Dong, Matthew R. Nelson, Eric Vallabh Minikel

Transcript expression-aware annotation improves rare variant interpretation

Nature(2020)10.1038/s41586-020-2329-2

N/A

0.796DataRank · unranked

201 citations

Konrad J. Karczewski, Ditte Demontis, Eleanor G. Seaby, Nicholas A. Watts, Moriel Singer-Berk +177 more

Evaluating drug targets through human loss-of-function genetic variation

Nature(2020)10.1038/s41586-020-2267-z

N/A

0.779DataRank · unranked

179 citations

Konrad J. Karczewski, Hilary C. Martin, Beryl B. Cummings, Nicola Whiffin, Daniel R. Rhodes +150 more

In vivo base editing extends lifespan of a humanized mouse model of prion disease

Nature Medicine(2025)10.1038/s41591-024-03466-w

N/A

0.696DataRank · unranked

42 citations

Jessie R. Davis, Jonathan M. Levy, Fiona E. Serack, John W. Harvey, Pamela P. Brauer +22 more

Prion protein lowering is a disease-modifying therapy across prion disease stages, strains, and endpoints

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.03.27.011940

N/A

0.312DataRank · unranked

7 citations

Hien T Zhao, Jason Le, Jill O’Moore, Rose Pitstick, Samantha Graffam +19 more

Modulation of prion protein expression through cryptic splice site manipulation

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.12.19.572439

N/A

0.104DataRank · unranked

1 citations

Taylor L Corridon, Meredith A Mortberg, Elston N. D’Souza, Nicola Whiffin, Eric Vallabh Minikel +2 more

Mortality of individuals with antemortem genetic testing for PRNP variants in the United States, 1998-2024

medRxiv(2025)10.1101/2025.10.03.25337271

Top 78%

0.104DataRank

Top 78%1 citations

Keisi Kotobelli, Kathleen Glisic, Daniel A Sprague, Sonia M. Vallabh, Brian S. Appleby +2 more

Regional variability and genotypic and pharmacodynamic effects on PrP concentration in the CNS

JCI Insight(2022)10.1172/jci.insight.156532

N/A

0DataRank · unranked

28 citations

Hien Zhao, Andrew G. Reidenbach, Juliana E Gentile, Eric Kuhn, Jill O’Moore +15 more

Analysis of non-human primate models for evaluating prion disease therapeutic efficacy

PLoS Pathogens(2022)10.1371/journal.ppat.1010728

N/A

0DataRank · unranked

8 citations

Eric Vallabh Minikel, Sonia M. Vallabh, Meredith A Mortberg

Therapeutic trial of anle138b in mouse models of genetic prion disease

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.10.11.511739

N/A

0DataRank · unranked

1 citations

Dan Zou, Rose Pitstick, Jill O’Moore, Janet Peters, Derek Silvius +6 more

Analysis of non-human primate models for evaluating prion disease therapeutic efficacy

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.03.22.485331

N/A

0DataRank · unranked

0 citations

Eric Vallabh Minikel, Sonia M. Vallabh, Meredith A Mortberg

Prion protein lowering is a disease-modifying therapy across prion disease stages, strains and endpoints

Nucleic Acids Research(2020)10.1093/nar/gkaa616

N/A

0DataRank · unranked

144 citations

Hien Zhao, Jason Le, Jill O’Moore, Rose Pitstick, Samantha Graffam +19 more

Therapeutic Trial of anle138b in Mouse Models of Genetic Prion Disease

Journal of Virology(2023)10.1128/jvi.01672-22

N/A

0DataRank · unranked

17 citations

Dan Zou, Rose Pitstick, Jill O’Moore, Janet Peters, Derek Silvius +6 more

Where have prions been all our lives?

Brain(2023)10.1093/brain/awad143

N/A

0DataRank · unranked

2 citations

Sonia M. Vallabh, Eric Vallabh Minikel

A single-cell map of antisense oligonucleotide activity in the brain

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.02.14.528473

N/A

0DataRank · unranked

5 citations

Juliana E Gentile, Naeem Nadaf, Charles R. Vanderburg, Sean K. Simmons, Dan Dubinsky +9 more

Biomarker changes preceding symptom onset in genetic prion disease

medRxiv(2023)10.1101/2023.12.18.23300042

N/A

0DataRank · unranked

2 citations

Meredith A Mortberg, Shona W. Allen, Ashley C. Kupferschmid, Pia Kivisäkk, Bruno L. Hammerschlag +12 more

Brainwide silencing of prion protein by AAV-mediated delivery of an engineered compact epigenetic editor

Science(2024)10.1126/science.ado7082

N/A

0DataRank · unranked

106 citations

Tessa M. Bertozzi, Elaine Wu, Fiona E. Serack, John W. Harvey, Pamela P. Brauer +13 more

Modulation of prion protein expression through cryptic splice site manipulation

Journal of Biological Chemistry(2024)10.1016/j.jbc.2024.107560

N/A

0DataRank · unranked

2 citations

Taylor L Corridon, Meredith A Mortberg, Elston N. D’Souza, Nicola Whiffin, Eric Vallabh Minikel +2 more

Evidence that minocycline treatment confounds the interpretation of neurofilament as a biomarker

Brain Communications(2025)10.1093/braincomms/fcaf175

N/A

0DataRank · unranked

4 citations

Christina N. Heiss, Taylor L Corridon, Meredith A Mortberg, Stefanie Fruhwürth, Kenia Guzman +18 more

Search for a genetic cause of variably protease-sensitive prionopathy

PLoS Pathogens(2025)10.1371/journal.ppat.1013343

N/A

0DataRank · unranked

2 citations

Keisi Kotobelli, Stacey Hall, Michael E. Talkowski, Anne H. O’Donnell-Luria, Sonia M. Vallabh +3 more

A single-cell map of antisense oligonucleotide activity in the brain

Nucleic Acids Research(2023)10.1093/nar/gkad371

N/A

0DataRank · unranked

52 citations

Juliana E Gentile, Naeem Nadaf, Charles R. Vanderburg, Sean K. Simmons, Dan Dubinsky +9 more

Quantifying prion disease penetrance using large population control cohorts

UNC Libraries(2020)10.17615/m8r0-g416

N/A

0DataRank · unranked

1 citations

Hidehiro Mizusawa, Pamela Sklar, Nobuo Sanjo, Miguel Calero, Theo F. J. Kraus +58 more

Multimodal small-molecule screening for human prion protein binders

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.06.18.159418

N/A

0DataRank · unranked

3 citations

Michael F. Mesleh, Dominick Casalena, Sonia M. Vallabh, Jayme L. Dahlin, Alison Leed +21 more

Novel quaternary structures of the human prion protein globular domain

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.11.16.385856

N/A

0DataRank · unranked

1 citations

V.L. Rangel, Francesca A. Pavlovici, Kamel El Omari, Armin Wagner, J. Brandão-Neto +8 more

PrP concentration in the central nervous system: regional variability, genotypic effects, and pharmacodynamic impact

medRxiv(2021)10.1101/2021.11.01.21265619

N/A

0DataRank · unranked

0 citations

Hien Zhao, Andrew G. Reidenbach, Juliana E Gentile, Eric Kuhn, Jill O’Moore +15 more

Disease stages and therapeutic hypotheses in two decades of neurodegenerative disease clinical trials

Scientific Reports(2022)10.1038/s41598-022-21820-1

N/A

0DataRank · unranked

33 citations

Sonia M. Vallabh, Eric Vallabh Minikel, Meredith A Mortberg

Eric Vallabh Minikel

Indexed papers

Top data-sharing exemplar

Papers