Discrimination of 5′‐terminal start codons by translation initiation factor 3 is mediated by ribosomal protein S1 is a research paper published in FEBS Letters (1998). On theSindex it has a DataRank of 2.1. It has been cited 40 times, with 24 citing works in its 1-hop citation network.
The interrelation between ribosomal protein S1 and IF3 in recognition/discrimination of 5′‐terminal start codons by 30S ribosomes has been studied using in vitro toeprinting. The study has been performed with two naturally occurring leaderless mRNAs, λ cI and phage r1t rro mRNA, as well as with an artificial leaderless mRNA derived from the E. coli ompA gene. We show that in the absence of S1, IF3 does not discriminate against the authentic 5′‐terminal start codon of both cI and rro mRNA. Since IF3 was able to exert its proofreading function for initiator on 30S ribosomes lacking S1, this observation cannot be attributed to a lack of binding to or action of IF3 on 30S(−S1) ribosomes. In contrast to leaderless mRNAs, ternary complex formation occurs in the presence of IF3 with 30S ribosomes when the start codon is preceded by a short 20‐nucleotide 5′‐untranslated region containing a canonical Shine and Dalgarno sequence. This suggests that 5′‐terminal start codons are recognised by IF3 as non‐standard because of the lack of 16S rRNA‐mRNA contacts.
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Base Score Contribution
0.557
From this paper's citation signal
Citation Network Contribution
1.5
From 23 citing papers with measurable signal
Ranked by citation count — the same ordering the engine uses when summing log1p(Cq) over citers.
DataRank blends this paper's own citation count with the influence of the papers that cite it. Here, roughly 27% comes from its base citations and 73% from the citation network (23 citing papers contributed measurable signal).
Citers are pulled from OpenAlex sorted by cited_by_count:descand capped per paper, so when the cap binds we keep the highest-signal references and the score is reproducible across reruns.
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