Requirements for ribosomal protein S1 for translation initiation of mRNAs with and without a 5′ leader sequence is a research paper published in Molecular Microbiology (1997). On theSindex it has a DataRank of 3.5. It has been cited 76 times, with 63 citing works in its 1-hop citation network.
It has previously been proposed that Escherichia coli ribosomal protein S1 is required for the translation of highly structured mRNAs. In this study, we have examined the influence of structural features at or near the start codon of different mRNAs. The requirement for ribosomal protein S1 for translation initiation was determined when (i) the ribosome‐binding site (RBS) was either preceded by a 5′ non‐translated leader sequence; (ii) the RBS was located 5′ proximal to a mRNA start codon; and (iii) the start codon was the 5′ terminal codon as exemplified by leaderless mRNAs. In vitro translation studies revealed that the leaderless lambda cI mRNA is translated with Bacillus stearothermophilus ribosomes, naturally lacking a ribosomal protein S1 homologue, whereas ompA mRNA containing a 5′ leader is not. These studies have been verified by toeprinting with E. coli ribosomes depleted for S1. We have shown that S1 is required for ternary complex formation on ompA mRNA but not for leaderless mRNAs or for mRNAs in which the RBS is close to the 5′ end.
FAIR checklist signals are shown for context only and do not affect DataRank scoring.
Base Score Contribution
0.652
From this paper's citation signal
Citation Network Contribution
2.9
From 55 citing papers with measurable signal
Ranked by citation count — the same ordering the engine uses when summing log1p(Cq) over citers.
DataRank blends this paper's own citation count with the influence of the papers that cite it. Here, roughly 18% comes from its base citations and 82% from the citation network (55 citing papers contributed measurable signal).
Citers are pulled from OpenAlex sorted by cited_by_count:descand capped per paper, so when the cap binds we keep the highest-signal references and the score is reproducible across reruns.
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