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Harnessing AlphaFold to reveal hERG channel conformational state secrets

(2024)10.1101/2024.01.27.577468Source: DataRank Database

Harnessing AlphaFold to reveal hERG channel conformational state secrets is a research paper (2024). On theSindex it has a DataRank of 0.182. It has been cited 2 times, with 2 citing works in its 1-hop citation network.

N/A

0.182DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access2 citations · 2 citing works in its network

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Data from: Harnessing AlphaFold to reveal hERG channel conformational state secrets · Dryad

Data availability

Repositories this paper deposited data in (declared in PubMed).

Dryad10.5061/dryad.18931zd5x

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (17 grants)OA: greenTopics (56)Linked Datasets (1)DataCite Reuse (1)IDs (PubMed, OpenAlex)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (2/2)

Has DOI
Indexed in repositories

Accessible (1/2)

Open Access

Interoperable (2/2)

DataCite relations
Linked datasets

Reusable (0/3)

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DataRank Breakdown

Base Score 91%Citation Network 9%

Base Score Contribution

0.165

From this paper's citation signal

Citation Network Contribution

0.0169

From 2 citing papers with measurable signal

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Top 2 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 2 citers.

Molecular Insights into the Rescue Mechanism of an hERG Activator Against Severe LQT2 Mutations.
bioRxiv (Cold Spring Harbor Laboratory)20242 citations70 referencesContributes 0.016
Translating cardiovascular ion channel and Ca 2+ signalling mechanisms into therapeutic insights
The Journal of Physiology20263 citations335 referencesContributes 0.004

Authors (5)

Pei‐Chi Yang ORCID,Vladimir Yarov‐Yarovoy ORCID,Colleen E. Clancy ORCID,Igor Vorobyov ORCID,Khoa Ngo ORCID

Live enrichment

PubMed:38352360 OpenAlex:https://openalex.org/W4391338610

National Institutes of Health

Grant: 5R01HL128537-02

In silico Safety Pharmacology

National Science Foundation

Grant: 2032486

Frontera Travel Grant: Enhanced Atomistic Simulations for Predictive Multi-Scale Modeling Safety Pharmacology Pipeline

National Institutes of Health

Grant: 5R01HL174001-02

Digital Twins from the Atom to the Rhythm

National Institutes of Health

Grant: 5R01HL085844-12

Functional Interactions of Cardiac Ion Channels

National Institutes of Health

Grant: 5U01HL126273-04

Predictive multiscale in silico cardio-pharmacology

National Institutes of Health

Grant: 2T32HL086350-16A1

Training Program in Basic and Translational Cardiovascular Science

National Institutes of Health

Grant: 5R01HL152681-03

Multi-Scale Modeling of Vascular Signaling Units

National Institutes of Health

Grant: 5R01GM116961-04

Breakthrough Molecular Dynamics Research via an Anton2 Supercomputer

National Institutes of Health

Grant: 3OT2OD026580-01S4

Development of the Predictive NeuroCardiovascular Simulator

NHLBI NIH HHS

Grant: R01 HL128537

NIH HHS

Grant: OT2 OD026580

NHLBI NIH HHS

Grant: T32 HL086350

NHLBI NIH HHS

Grant: R01 HL152681

NHLBI NIH HHS

Grant: U01 HL126273

NHLBI NIH HHS

Grant: R01 HL174001

NIGMS NIH HHS

Grant: R01 GM116961

NHLBI NIH HHS

Grant: R01 HL085844

greenLicense: cc-by-nc-nd

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2024/01/30/2024.01.27.577468.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2024.01.27.577468

repositoryhttps://doi.org/10.1101/2024.01.27.577468

repositoryhttps://pubmed.ncbi.nlm.nih.gov/38352360

Fields of Study

Cardiac electrophysiology and arrhythmiasProtein Structure and DynamicsIon channel regulation and function0301 basic medicine03 medical and health sciences

Keywords

hERGChemistryComputational biologyDrug discoveryDrugMolecular dynamicsIon channelDocking (animal)BiophysicsPharmacologyPotassium channelComputational chemistryBiologyBiochemistryMedicineERG1 Potassium ChannelQH301-705.5Protein ConformationScience0601 Biochemistry and Cell Biology (for)Molecular Docking Simulation (mesh)chemical biologyAlphaFoldMolecular Dynamics SimulationarrhythmiaArticleMolecular Dynamics Simulation (mesh)42 Health sciences (for-2020)Biochemistry and Chemical Biology31 Biological sciences (for-2020)molecular biophysicsstructural biologyHumanshumanBiology (General)32 Biomedical and Clinical Sciences (for-2020)1.1 Normal biological development and functioning (hrcs-rac)voltage-gated potassium channelHumans (mesh)Networking and Information Technology R&D (NITRD) (rcdc)Cardiovascular (hrcs-hc)Protein Conformation (mesh)Patient Safety (rcdc)Generic health relevance (hrcs-hc)QRmolecular dockingMolecular Docking SimulationERG1 Potassium Channel (mesh)Cardiovascular (rcdc)Structural Biology and Molecular Biophysics

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Data from: Harnessing AlphaFold to reveal hERG channel conformational state secrets

10.5061/dryad.18931zd5xDryad