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Accurate Prediction of Protein Tertiary and Quaternary Stability Using Fine-Tuned Protein Language Models and Free Energy Perturbation

International Journal of Molecular Sciences(2025)10.3390/ijms26157125Source: DataRank Database

Accurate Prediction of Protein Tertiary and Quaternary Stability Using Fine-Tuned Protein Language Models and Free Energy Perturbation is a research paper published in International Journal of Molecular Sciences (2025). On theSindex it has a DataRank of 0. It has been cited 2 times.

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Open Access2 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (9 grants)Impact (FWCI 0.79)OA: goldTopics (43)IDs (PubMed, PMC, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (5)

Ryann M. Perez ORCID,John J. Ferrie ORCID,E. James Petersson ORCID,Sam Giannakoulias ORCID,X.D. Li ORCID

Live enrichment

PubMed:40806259 PMC:PMC12345697 OpenAlex:https://openalex.org/W4412642503

University of Pennsylvania

Grant: NIH RF1-NS103873

University of Pennsylvania

Grant: T32-GM133398

University of Pennsylvania

Grant: F31-AG090063

University of Pennsylvania

Grant: NCF CHE-2203909

University of Pennsylvania

Grant: DGE-1845298

NIA NIH HHS

Grant: F31 AG090063

NINDS NIH HHS

Grant: RF1 NS103873

NIH HHS

Grant: NIH RF1-NS103873 to E.J.P.

NIGMS NIH HHS

Grant: T32 GM133398

FWCI

0.79

Citation Percentile

0.7%

Citation Trend

2026

goldLicense: cc-by

journalhttps://www.mdpi.com/1422-0067/26/15/7125/pdf?version=1753336031

publisherhttps://www.mdpi.com/1422-0067/26/15/7125/pdf?version=1753336031

publisherhttps://www.mdpi.com/1422-0067/26/15/7125/pdf

journalhttps://doi.org/10.3390/ijms26157125

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40806259

Fields of Study

Protein Structure and DynamicsRNA and protein synthesis mechanismsMachine Learning in BioinformaticsProtein StabilityThermodynamicsProteinsModels, MolecularMutationProtein FoldingGreen Fluorescent ProteinsProtein Structure, TertiaryProtein Structure, QuaternaryComputational Biology

MeSH Terms

Models, MolecularMutationProteinsThermodynamicsProtein Structure, TertiaryProtein FoldingComputational BiologyProtein Structure, QuaternaryGreen Fluorescent ProteinsProtein Stability

Keywords

Protein tertiary structureProtein stabilityStability (learning theory)Protein quaternary structureProtein foldingPerturbation (astronomy)Biological systemComputer scienceProtein designProtein structure predictionProtein functionProtein structureChemistryBiologyPhysicsMachine learningBiochemistryProtein subunitProtein Complex StabilityProtein Language Models

Sustainable Development Goals

SDG 0: Affordable and clean energy