Jian Jin

Also affiliated with Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai

ChemistryBiochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

1in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 1 indexed paper attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

Papers

Driven by 131 papers. Top paper: “Cancer Selective Target Degradation by Folate-Caged PROTACs”.

Cancer Selective Target Degradation by Folate-Caged PROTACs

Journal of the American Chemical Society(2021)10.1021/jacs.1c00451

N/A

8.4DataRank · unranked

292 citations

He Chen, Yi Liu, Yudao Shen, Fanye Meng, H. Ümit Kanıskan +3 more

Methylation of dual-specificity phosphatase 4 controls cell differentiation

Cell Reports(2021)10.1016/j.celrep.2021.109421

N/A

1.1DataRank · unranked

34 citations

Ming Jiang, Chamara Senevirathne, Srinivas Aluri, Tuo Zhang, Han Guo +27 more

Human WDR5 promotes breast cancer growth and metastasis via KMT2-independent translation regulation

eLife(2022)10.7554/elife.78163

N/A

0.807DataRank · unranked

27 citations

Jocelyn Fang-Yi Chen, Huacui Chen, Emily Wingrove, Sarah J. Kurley, Lok-Hei Chan +14 more

Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer’s Disease

Neuron(2020)10.1016/j.neuron.2020.11.002

N/A

0.806DataRank · unranked

215 citations

Aiqun Li, Michiko Sekiya, Noam D. Beckmann, Xiuming Quan, Nadine Schrode +37 more

Bridged Proteolysis Targeting Chimera (PROTAC) Enables Degradation of Undruggable Targets

Journal of the American Chemical Society(2022)10.1021/jacs.2c09255

N/A

0.736DataRank · unranked

134 citations

Yue Zhong, Hyerin Yim, Xiaobao Yang, Kwang‐Su Park, Ling Xie +7 more

Folate-Guided Protein Degradation by Immunomodulatory Imide Drug-Based Molecular Glues and Proteolysis Targeting Chimeras

Journal of Medicinal Chemistry(2021)10.1021/acs.jmedchem.1c00901

N/A

0.712DataRank · unranked

114 citations

Jing Liu, H. Ümit Kanıskan, Wenyi Wei, Jian Jin, He Chen

A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells

Cell chemical biology(2021)10.1016/j.chembiol.2021.08.004

N/A

0.624DataRank · unranked

63 citations

Fanye Meng, Kwang‐Su Park, Aaron J. Storey, Weida Gong, Yi‐Hsuan Tsai +12 more

Targeting Triple-Negative Breast Cancer by a Novel Proteolysis Targeting Chimera Degrader of Enhancer of Zeste Homolog 2

ACS Pharmacology & Translational Science(2022)10.1021/acsptsci.2c00100

N/A

0.621DataRank · unranked

62 citations

Chris Anderson, Kwang‐Su Park, H. Ümit Kanıskan, Anqi Ma, Yudao Shen +6 more

Targeting the methyltransferase SETD8 impairs tumor cell survival and overcomes drug resistance independently of p53 status in multiple myeloma

Clinical Epigenetics(2021)10.1186/s13148-021-01160-z

N/A

0.590DataRank · unranked

50 citations

Sara Ovejero, Fanny Izard, Ouissem Karmous-Gadacha, Claire Gourzonès, Céline Bellanger +10 more

Discovery of a novel, highly potent EZH2 PROTAC degrader for targeting non-canonical oncogenic functions of EZH2

European Journal of Medicinal Chemistry(2024)10.1016/j.ejmech.2024.116154

N/A

0.546DataRank · unranked

37 citations

Brandon Dale, Kwang‐Su Park, H. Ümit Kanıskan, Xufen Yu, Jian Jin +1 more

Targeted Degradation of PRC1 Components, BMI1 and RING1B, via a Novel Protein Complex Degrader Strategy

Advanced Science(2023)10.1002/advs.202205573

N/A

0.505DataRank · unranked

28 citations

Lihuai Qin, Md Kabir, Kaixiu Luo, Brandon Dale, Yue Zhong +5 more

Dissecting and targeting noncanonical functions of EZH2 in multiple myeloma via an EZH2 degrader

Oncogene(2023)10.1038/s41388-023-02618-5

N/A

0.494DataRank · unranked

26 citations

Jun Wang, Weida Gong, Anqi Ma, Yudao Shen, Chengwei Zhang +6 more

USP2 inhibition prevents infection with ACE2-dependent coronaviruses in vitro and is protective against SARS-CoV-2 in mice

Science Translational Medicine(2023)10.1126/scitranslmed.adh7668

N/A

0.449DataRank · unranked

19 citations

Lei Bai, Jiazhen Dong, Xiaoping Hu, Jingchao Wang, Joao A. Paulo +22 more

Developing new PI3Kγ inhibitors by combining pharmacophore modeling, molecular dynamic simulation, molecular docking, fragment-based drug design, and virtual screening

Computational Biology and Chemistry(2023)10.1016/j.compbiolchem.2023.107879

N/A

0.360DataRank · unranked

10 citations

Dan Sun, Xintong Li, Lei Jia, Yanfei Cai, Yun Chen +3 more

Discovery of the first-in-class DOT1L PROTAC degrader

European Journal of Medicinal Chemistry(2025)10.1016/j.ejmech.2025.117595

N/A

0.345DataRank · unranked

9 citations

Renhong Sun, Zhongli Xu, Huen Suk Kim, Min Jeong Kim, Tao Cao +5 more

Application of established computational techniques to identify potential SARS-CoV-2 Nsp14-MTase inhibitors in low data regimes

Digital Discovery(2024)10.1039/d4dd00006d

N/A

0.345DataRank · unranked

9 citations

Matthew F. D. Hurley, Fengling Li, Eva Konkoľová, Martin Klíma, Jana Trylčová +21 more

Design, Synthesis, and Evaluation of p53Y220C Acetylation Targeting Chimeras (AceTACs)

Journal of Medicinal Chemistry(2024)10.1021/acs.jmedchem.4c01497

N/A

0.330DataRank · unranked

8 citations

Md Kabir, Yindan Lin, Yan Xiong, Ramon Parsons, Wei Gu +2 more

Drug Discovery in Low Data Regimes: Leveraging a Computational Pipeline for the Discovery of Novel SARS-CoV-2 Nsp14-MTase Inhibitors

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.10.03.560722

N/A

0.165DataRank · unranked

2 citations

Matthew F. D. Hurley, Fengling Li, Eva Konkoľová, Martin Klíma, Jana Trylčová +21 more

Loss of tumor cell MHC Class II drives insensitivity of BRAF-mutant anaplastic thyroid cancers to MAPK inhibitors

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.01.27.635086

N/A

0.165DataRank · unranked

2 citations

Jillian Greenberg, Tianyue Qin, Soo-Yeon Im, Gnana P. Krishnamoorthy, Laura Boucai +12 more

Targeting G9a-m6A translational mechanism of SARS-CoV-2 pathogenesis for multifaceted therapeutics of COVID-19 and its sequalae

iScience(2025)10.1016/j.isci.2025.112632

N/A

0.165DataRank · unranked

2 citations

Ling Xie, Xuping Xie, Feng Zhang, John A. Wrobel, Yan Xiong +11 more

ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism

Nature Communications(2021)10.1038/s41467-021-21357-3

N/A

0DataRank · unranked

42 citations

Phillip M. Galbo, Weida Gong, Aaron J. Storey, Yi‐Hsuan Tsai, Xufen Yu +13 more

NOTCH and EZH2 collaborate to repress PTEN expression in breast cancer

Communications Biology(2021)10.1038/s42003-021-01825-8

N/A

0DataRank · unranked

37 citations

Tiphaine Martin, Andrew L. Wolfe, Christie B. Nguyen, Tao Su, Jian Jin +3 more

A promising chemical series of positive allosteric modulators of the μ-opioid receptor that enhance the antinociceptive efficacy of opioids but not their adverse effects

Neuropharmacology(2021)10.1016/j.neuropharm.2021.108673

N/A

0DataRank · unranked

34 citations

Hye Jin Kang, Farhana Sakloth, Yongfeng Liu, Susan Khan, Katalin Tóth +12 more

Inhibition of EZH2 primes the cardiac gene activation via removal of epigenetic repression during human direct cardiac reprogramming

Stem Cell Research(2021)10.1016/j.scr.2021.102365

N/A

0DataRank · unranked

30 citations

Lianzhong Zhao, Xufen Yu, Jianyi Zhang, Qian Li, Jian Jin +3 more

A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6

Journal of Medicinal Chemistry(2021)10.1021/acs.jmedchem.0c02160

N/A

0DataRank · unranked

27 citations

Fengling Li, Magdalena M. Szewczyk, Levon Halabelian, Irene Chau, Mohammad S. Eram +22 more

Gq signaling in α cells is critical for maintaining euglycemia

JCI Insight(2021)10.1172/jci.insight.152852

N/A

0DataRank · unranked

26 citations

Diptadip Dattaroy, Katherine F. Simpson, Luiz F. Barella, Yinghong Cui, Yan Xiong +8 more

UV-induced reduction in Polycomb repression promotes epidermal pigmentation

Developmental Cell(2021)10.1016/j.devcel.2021.08.006

N/A

0DataRank · unranked

21 citations

Pooja Flora, Hong Pu, Carmit Bar, José Silva, Idan Cohen +9 more

SOX11 Inhibitors Are Cytotoxic in Mantle Cell Lymphoma

Clinical Cancer Research(2021)10.1158/1078-0432.ccr-20-5039

N/A

0DataRank · unranked

10 citations

Stephanie Christie, Violetta V. Leshchenko, Rinku Jain, Abhijeet Kapoor, Paola Bisignano +13 more

MDR1 Drug Efflux Pump Promotes Intrinsic and Acquired Resistance to PROTACs in Cancer Cells

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.12.02.470920

N/A

0DataRank · unranked

12 citations

Carlos Herrera-Montávez, Sara Montserrat, Daniela Araiza, Jianping Hu, Jian Jin +2 more

Probing the SAM Binding Site of SARS-CoV-2 nsp14 in vitro Using SAM Competitive Inhibitors Guides Developing Selective bi-substrate Inhibitors

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.02.19.424337

N/A

0DataRank · unranked

11 citations

Matthieu Schapira, Sumera Perveen, Aliakbar Khalili Yazdi, Fengling Li, Irene Chau +15 more

A Promising Chemical Series of Positive Allosteric Modulators of the μ-Opioid Receptor that Enhance the Antinociceptive Efficacy of Opioids but not their Adverse Effects

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.05.24.445057

N/A

0DataRank · unranked

0 citations

Hye Jin Kang, Farhana Sakloth, Yongfeng Liu, Susan Khan, Katalin Tóth +12 more

Small-molecule ligands of methyl-lysine binding proteins: Optimization of selectivity for L3MBTL3

Figshare(2021)10.17615/x6qe-4112

N/A

0DataRank · unranked

0 citations

Masoud Vedadi, Lindsey A. Ingerman, Robert Lam, Victoria Korboukh, J. Martin Herold +11 more

EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis

Nature Cell Biology(2022)10.1038/s41556-022-00850-x

N/A

0DataRank · unranked

184 citations

Xufen Yu, Weida Gong, Xijuan Liu, Kwang‐Su Park, Anqi Ma +12 more

The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells

Science Signaling(2022)10.1126/scisignal.abn2707

N/A

0DataRank · unranked

111 citations

Carlos Herrera-Montávez, Sara Montserrat‐Sangrà, Daniela Araiza‐Olivera, Jianping Hu, Ryan Neumann-Domer +6 more

TF-DUBTACs Stabilize Tumor Suppressor Transcription Factors

Journal of the American Chemical Society(2022)10.1021/jacs.2c04824

N/A

0DataRank · unranked

61 citations

Xufen Yu, He Chen, H. Ümit Kanıskan, Ling Xie, Xian Chen +3 more

Discovery of a First-in-Class Degrader for Nuclear Receptor Binding SET Domain Protein 2 (NSD2) and Ikaros/Aiolos

Journal of Medicinal Chemistry(2022)10.1021/acs.jmedchem.2c00807

N/A

0DataRank · unranked

58 citations

Chenxi Xu, Kwang‐Su Park, H. Ümit Kanıskan, Gang Greg Wang, Jian Jin +1 more

Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic

Oncogene(2022)10.1038/s41388-022-02340-8

N/A

0DataRank · unranked

56 citations

Xufen Yu, Jithesh Kottur, Weida Gong, Zhao Zhang, Aaron J. Storey +14 more

RETRACTED ARTICLE: ROCK1 mechano-signaling dependency of human malignancies driven by TEAD/YAP activation

Nature Communications(2022)10.1038/s41467-022-28319-3

N/A

0DataRank · unranked

55 citations

Ila Pant, Yao Shen, Rui Fang Qiao, Xiaobao Yang, Yiyang Bai +4 more

Discovery of the First-in-Class G9a/GLP Covalent Inhibitors

Journal of Medicinal Chemistry(2022)10.1021/acs.jmedchem.2c00652

N/A

0DataRank · unranked

46 citations

Yan Xiong, Hyerin Yim, Julia Velez, Nicolas Babault, Prashasti Kumar +3 more

A cryptic transactivation domain of EZH2 binds AR and AR’s splice variant, promoting oncogene activation and tumorous transformation

Nucleic Acids Research(2022)10.1093/nar/gkac861

N/A

0DataRank · unranked

41 citations

Kwang‐Su Park, Xufen Yu, Weida Gong, H. Shelton Earp, Gang Greg Wang +3 more

Discovery of the First Lactate Dehydrogenase Proteolysis Targeting Chimera Degrader for the Treatment of Pancreatic Cancer

Journal of Medicinal Chemistry(2022)10.1021/acs.jmedchem.2c01505

N/A

0DataRank · unranked

38 citations

Md Kabir, Youngeun Lee, Ling Xie, Xiaoping Hu, Julia Velez +4 more

Novel Allosteric Inhibitor-Derived AKT Proteolysis Targeting Chimeras (PROTACs) Enable Potent and Selective AKT Degradation in KRAS/BRAF Mutant Cells

Journal of Medicinal Chemistry(2022)10.1021/acs.jmedchem.2c01454

N/A

0DataRank · unranked

35 citations

Jia Xu, Kaitlyn M. Cahuzac, Ling Xie, Yudao Shen, Xian Chen +4 more

An MDM2 degrader for treatment of acute leukemias

Leukemia(2022)10.1038/s41375-022-01735-6

N/A

0DataRank · unranked

34 citations

Xiaobao Yang, H. Ümit Kanıskan, Claudia Brady, He Chen, Karie Chen +13 more

Inactive and active state structures template selective tools for the human 5-HT5A receptor

Nature Structural & Molecular Biology(2022)10.1038/s41594-022-00796-6

N/A

0DataRank · unranked

29 citations

He Chen, Chengwei Zhang, Yang Ying, Petr Popov, Jing Liu +10 more

Discovery of Potent, Selective, and In Vivo Efficacious AKT Kinase Protein Degraders via Structure–Activity Relationship Studies

Journal of Medicinal Chemistry(2022)10.1021/acs.jmedchem.1c02165

N/A

0DataRank · unranked

39 citations

Jia Xu, Yudao Shen, Kaitlyn M. Cahuzac, Kwang‐Su Park, Brandon Dale +4 more

Exploring Degradation of Mutant and Wild-Type Epidermal Growth Factor Receptors Induced by Proteolysis-Targeting Chimeras

Journal of Medicinal Chemistry(2022)10.1021/acs.jmedchem.2c00345

N/A

0DataRank · unranked

33 citations

Meng Cheng, Kaylene Lu, Yudao Shen, Yue Zhong, Jing Liu +3 more

Identification of an Epi-metabolic dependency on EHMT2/G9a in T-cell acute lymphoblastic leukemia

Cell Death and Disease(2022)10.1038/s41419-022-05002-5

N/A

0DataRank · unranked

13 citations

Samuel Kitara, Elisa Cerretani, Matteo Marchesini, Chiara Rompietti, Luca Pagliaro +24 more

A cryptic transactivation domain of EZH2 binds AR and AR’s splice variant promoting oncogene activation and tumorous transformation

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.08.04.502794

N/A

0DataRank · unranked

5 citations

Kwang‐Su Park, Xufen Yu, Weida Gong, H. Shelton Earp, Gang Greg Wang +3 more

Targeted degradation of PRC1 components, BMI1 and RING1B, via a novel protein complex degrader strategy

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.11.19.517138

N/A

0DataRank · unranked

2 citations

Lihuai Qin, Md Kabir, Kaixiu Luo, Brandon Dale, Yue Zhong +5 more

WDR5 promotes breast cancer growth and metastasis via KMT2-independent translation regulation

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.03.30.486357

N/A

0DataRank · unranked

0 citations

Jocelyn Fang-Yi Chen, Huacui Chen, Emily Wingrove, Sarah J. Kurley, Lok-Hei Chan +13 more

Inhibition of USP7 induces p53-independent tumor growth suppression in triple-negative breast cancers by destabilizing FOXM1

Cell Death and Differentiation(2023)10.1038/s41418-023-01180-7

N/A

0DataRank · unranked

62 citations

Huan Li, Bo Chu, Ning Kon, Xiaoping Hu, Jianping Hu +5 more

Acetylation Targeting Chimera Enables Acetylation of the Tumor Suppressor p53

Journal of the American Chemical Society(2023)10.1021/jacs.3c04640

N/A

0DataRank · unranked

55 citations

Ning Sun, Xiaoping Hu, Tiphaine Martin, Jingjie Yi, Yue Zhong +6 more

Discovery of Potent and Selective WDR5 Proteolysis Targeting Chimeras as Potential Therapeutics for Pancreatic Cancer

Journal of Medicinal Chemistry(2023)10.1021/acs.jmedchem.3c01521

N/A

0DataRank · unranked

51 citations

Dongxu Li, Jithesh Kottur, Huen Suk Kim, Laura E. Herring, Yao Yu +9 more

Structure-Based Discovery of Inhibitors of the SARS-CoV-2 Nsp14 N7-Methyltransferase

Journal of Medicinal Chemistry(2023)10.1021/acs.jmedchem.2c02120

N/A

0DataRank · unranked

48 citations

Fengling Li, Elissa A. Fink, Irene Chau, Alice Shi Ming Li, Annia Rodríguez‐Hernández +18 more

Generation of host-directed and virus-specific antivirals using targeted protein degradation promoted by small molecules and viral RNA mimics

Cell Host & Microbe(2023)10.1016/j.chom.2023.05.030

N/A

0DataRank · unranked

39 citations

Jessica Ho, Fanye Meng, Simin Zheng, Andrew P. Kurland, Lu Tian +11 more

Chemically induced degradation of epigenetic targets

Chemical Society Reviews(2023)10.1039/d3cs00100h

N/A

0DataRank · unranked

28 citations

Xufen Yu, H. Ümit Kanıskan, Jian Jin, Md Kabir

Telomere Targeting Chimera Enables Targeted Destruction of Telomeric Repeat-Binding Factor Proteins

Journal of the American Chemical Society(2023)10.1021/jacs.3c02783

N/A

0DataRank · unranked

30 citations

Jing Liu, He Chen, Xing Qiu, Ling Xie, H. Ümit Kanıskan +4 more

WNTinib is a multi-kinase inhibitor with specificity against β-catenin mutant hepatocellular carcinoma

Nature Cancer(2023)10.1038/s43018-023-00609-9

N/A

0DataRank · unranked

27 citations

Mary E. Duffy, Alex P. Scopton, Frank Fonseca, Julia N. Zhao, Megan Schwarz +30 more

De Novo Design of κ-Opioid Receptor Antagonists Using a Generative Deep-Learning Framework

Journal of Chemical Information and Modeling(2023)10.1021/acs.jcim.3c00651

N/A

0DataRank · unranked

22 citations

Davide Provasi, Xing Qiu, H. Ümit Kanıskan, Xi‐Ping Huang, Jeffrey F. DiBerto +5 more

Epigenetic balance ensures mechanistic control of MLL amplification and rearrangement

Cell(2023)10.1016/j.cell.2023.09.009

N/A

0DataRank · unranked

18 citations

Damayanti Chakraborty, Reuben R. Duttweiler, Gulnaz D. Alekbaeva, Sedona E. Murphy, Kashish Chetal +21 more

Non-canonical function of histone methyltransferase G9a in the translational regulation of chronic inflammation

Cell chemical biology(2023)10.1016/j.chembiol.2023.09.012

N/A

0DataRank · unranked

17 citations

Li Wang, Ling Xie, Feng Zhang, Bing Wu, Mei Liu +15 more

Methylated Nucleotide-Based Proteolysis-Targeting Chimera Enables Targeted Degradation of Methyl-CpG-Binding Protein 2

Journal of the American Chemical Society(2023)10.1021/jacs.3c06023

N/A

0DataRank · unranked

13 citations

Jing Liu, Xing Qiu, Dingpeng Zhang, Hiroyuki Inuzuka, Li Chen +7 more

Recent advances in developing degraders & inhibitors of lysine methyltransferases

Current Opinion in Chemical Biology(2023)10.1016/j.cbpa.2023.102356

N/A

0DataRank · unranked

10 citations

H. Ümit Kanıskan, Jian Jin, Julia Velez

Chemical Epigenetic Regulation of Adeno-Associated Virus Delivered Transgenes

Human Gene Therapy(2023)10.1089/hum.2023.005

N/A

0DataRank · unranked

6 citations

Sara R Wasserman, Liujiang Song, Arushi A. Goel, Xufen Yu, Jian Jin +2 more

MS0621, a novel small-molecule modulator of Ewing sarcoma chromatin accessibility, interacts with an RNA-associated macromolecular complex and influences RNA splicing

Frontiers in Oncology(2023)10.3389/fonc.2023.1099550

N/A

0DataRank · unranked

6 citations

Aminah Wali, Kyle V. Butler, Yan Xiong, Joseph P. Foster, Shelsa S. Marcel +11 more

Novel brain-penetrant inhibitor of G9a methylase blocks Alzheimer’s disease proteopathology for precision medication

medRxiv(2023)10.1101/2023.10.25.23297491

N/A

0DataRank · unranked

6 citations

Ryan N. Sheehy, Yan Xiong, Adil Muneer, John A. Wrobel, Kwang‐Su Park +13 more

Structure-based discovery of inhibitors of the SARS-CoV-2 Nsp14 N7 -methyltransferase

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.01.12.523677

N/A

0DataRank · unranked

2 citations

Fengling Li, Elissa A. Fink, Irene Chau, Alice Li, Annia Rodríguez‐Hernández +18 more

De Novo Design of κ-Opioid Receptor Antagonists Using a Generative Deep Learning Framework

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.04.25.537995

N/A

0DataRank · unranked

1 citations

Davide Provasi, Xing Qui, H. Ümit Kanıskan, Xi‐Ping Huang, Jeffrey F. DiBerto +5 more

Novel small molecules inhibit proteotoxicity and inflammation: Mechanistic and therapeutic implications for Alzheimer’s Disease, healthspan and lifespan- Aging as a consequence of glycolysis

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.06.12.544352

N/A

0DataRank · unranked

1 citations

James M. Vicari, Bik Tzu Huang, Lila Shapiro, Kun-Hyung Roh, Aaron E. Silver +10 more

Novel brain-penetrant inhibitor of G9a methylase blocks Alzheimer’s disease proteopathology for precision medication

Research Square(2023)10.21203/rs.3.rs-2743792/v1

N/A

0DataRank · unranked

1 citations

Ling Xie, Ryan N. Sheehy, Yan Xiong, Adil Muneer, John A. Wrobel +13 more

Data from SOX11 Inhibitors Are Cytotoxic in Mantle Cell Lymphoma

(2023)10.1158/1078-0432.c.6530477

N/A

0DataRank · unranked

0 citations

Stephanie Christie, Violetta V. Leshchenko, Rinku Jain, Abhijeet Kapoor, Paola Bisignano +13 more

Data from SOX11 Inhibitors Are Cytotoxic in Mantle Cell Lymphoma

(2023)10.1158/1078-0432.c.6530477.v1

N/A

0DataRank · unranked

0 citations

Stephanie Christie, Violetta V. Leshchenko, Rinku Jain, Abhijeet Kapoor, Paola Bisignano +13 more

Bitter taste receptor activation by cholesterol and an intracellular tastant

Nature(2024)10.1038/s41586-024-07253-y

N/A

0DataRank · unranked

91 citations

Ryan H. Gumpper, Yongfeng Liu, D. Dewran Koçak, Yan Xiong, Can Cao +7 more

Structurally Specific Z-DNA Proteolysis Targeting Chimera Enables Targeted Degradation of Adenosine Deaminase Acting on RNA 1

Journal of the American Chemical Society(2024)10.1021/jacs.3c13646

N/A

0DataRank · unranked

30 citations

Dingpeng Zhang, Xing Qiu, Hiroyuki Inuzuka, Yan Xiong, Jing Liu +8 more

USP7-Based Deubiquitinase-Targeting Chimeras Stabilize AMPK

Journal of the American Chemical Society(2024)10.1021/jacs.4c02373

N/A

0DataRank · unranked

29 citations

Xiaoping Hu, Kaixiu Luo, Yan Xiong, Li Chen, Zhen Wang +11 more

The First‐In‐Class Deubiquitinase‐Targeting Chimera Stabilizes and Activates cGAS

Angewandte Chemie International Edition(2024)10.1002/anie.202415168

N/A

0DataRank · unranked

20 citations

Li Chen, Chao Qian, Jing Liu, Qiong Wu, Xiangyang Song +12 more

A potent and selective ENL degrader suppresses oncogenic gene expression and leukemia progression

Science Advances(2024)10.1126/sciadv.ado1432

N/A

0DataRank · unranked

14 citations

Lihuai Qin, Hongwen Xuan, Kaixiu Luo, Mengying Huang, Ling Xie +10 more

Discovery of the First-in-Class G9a/GLP PROTAC Degrader

Journal of Medicinal Chemistry(2024)10.1021/acs.jmedchem.3c02394

N/A

0DataRank · unranked

12 citations

Yulin Han, Hyerin Yim, Peiyi Yang, Zhijie Deng, Kwang‐Su Park +5 more

Discovery and Characterization of a Novel Cereblon-Recruiting PRC1 Bridged PROTAC Degrader

Journal of Medicinal Chemistry(2024)10.1021/acs.jmedchem.4c00538

N/A

0DataRank · unranked

11 citations

Lihuai Qin, Kaixiu Luo, Yan Xiong, Rebecca A. Sidi, Kwang‐Su Park +2 more

A PROTAC degrader suppresses oncogenic functions of PTK6, inducing apoptosis of breast cancer cells

Cell chemical biology(2024)10.1016/j.chembiol.2024.10.008

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ACS Pharmacology & Translational Science(2024)10.1021/acsptsci.4c00421

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bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.02.26.582210

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bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.03.04.583415

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Journal of the American Chemical Society(2025)10.1021/jacs.5c01889

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Journal of the American Chemical Society(2025)10.1021/jacs.5c01662

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Journal of Medicinal Chemistry(2025)10.1021/acs.jmedchem.5c00295

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Journal of the American Chemical Society(2025)10.1021/jacs.5c06306

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Proceedings of the National Academy of Sciences(2025)10.1073/pnas.2425812122

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Journal of Medicinal Chemistry(2025)10.1021/acs.jmedchem.5c00198

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9 citations

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Nature Communications(2025)10.1038/s41467-025-59128-z

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9 citations

Ryan N. Sheehy, Adil Muneer, Yan Xiong, John A. Wrobel, Feng Zhang +20 more

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Journal of Medicinal Chemistry(2025)10.1021/acs.jmedchem.4c02161

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Youngeun Lee, Yulin Han, Yue Zhong, Jujun Zhou, Joel Hrit +9 more

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Science Advances(2025)10.1126/sciadv.adu2292

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Journal of Medicinal Chemistry(2025)10.1021/acs.jmedchem.5c01315

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Molecular Psychiatry(2025)10.1038/s41380-025-02972-8

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Nature Communications(2025)10.1038/s41467-025-61156-8

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Blood Advances(2025)10.1182/bloodadvances.2025016801

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eLife(2025)10.7554/elife.105318.3

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Yong Sun, Han Guo, Chiao-Wang Sun, Qiuying Chen, Szumam Liu +19 more

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iScience(2025)10.1016/j.isci.2025.112387

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Scientific Reports(2025)10.1038/s41598-025-17093-z

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3 citations

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eLife(2025)10.7554/elife.105318

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Yong Sun, Han Guo, Chiao-Wang Sun, Qiuying Chen, Szumam Liu +19 more

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bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.03.11.642495

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bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.08.04.668477

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ACS Pharmacology & Translational Science(2025)10.1021/acsptsci.5c00402

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Journal of Clinical Investigation(2025)10.1172/jci195840

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Medicinal Research Reviews(2020)10.1002/med.21764

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Cancer Discovery(2020)10.1158/2159-8290.cd-19-0532

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Potent and Selective Mitogen-Activated Protein Kinase Kinase 1/2 (MEK1/2) Heterobifunctional Small-molecule Degraders

Journal of Medicinal Chemistry(2020)10.1021/acs.jmedchem.0c01609

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42 citations

Jieli Wei, Hyerin Yim, Li Wang, Ling Xie, Margaret S. Jin +6 more

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Journal of Medicinal Chemistry(2020)10.1021/acs.jmedchem.0c00406

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42 citations

Fengling Li, Magdalena M. Szewczyk, Levon Halabelian, Kwang‐Su Park, Irene Chau +11 more

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Figshare(2020)10.17615/q3bp-3c89

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bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.11.14.382416

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22 citations

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bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.12.04.412569

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1 citations

Fengling Li, Magdalena M. Szewczyk, Levon Halebelian, Irene Chau, Mohammad S. Eram +19 more

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UNC Libraries(2020)10.17615/n3y7-sa69

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UNC Libraries(2020)10.17615/e8jc-z164

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UNC Libraries(2020)10.17615/rmmr-1373

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Matthew R. Redinbo, Esteban G. Figueroa, James D. Ingle, Rebecca M. Pollet, Madhu Kumar Venkatesh +16 more

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Fengling Li, Ian J. Davis, Jian Jin, Dalia Barsyte-Lovejoy, Feng Liu +4 more

Pharmacologic modulation of RNA splicing enhances anti-tumor immunity

Cell(2021)10.1016/j.cell.2021.05.038

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284 citations

Emma De Neef, James D. Thomas, Erich Sabio, Benoı̂t Rousseau, Mathieu Gigoux +30 more

TF-PROTACs Enable Targeted Degradation of Transcription Factors

Journal of the American Chemical Society(2021)10.1021/jacs.1c03852

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He Chen, H. Ümit Kanıskan, Ling Xie, Xian Chen, Jian Jin +2 more

A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models

Science Translational Medicine(2021)10.1126/scitranslmed.abj1578

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Harnessing the E3 Ligase KEAP1 for Targeted Protein Degradation

Journal of the American Chemical Society(2021)10.1021/jacs.1c04841

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Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors

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Distinct CDK6 complexes determine tumor cell response to CDK4/6 inhibitors and degraders

Nature Cancer(2021)10.1038/s43018-021-00174-z

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AKT Degradation Selectively Inhibits the Growth of PI3K/PTEN Pathway–Mutant Cancers with Wild-Type KRAS and BRAF by Destabilizing Aurora Kinase B

Cancer Discovery(2021)10.1158/2159-8290.cd-20-0815

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Xufen Yu, Tiphaine Martin, Ankita Bansal, Kakit Cheung, Abigail Lubin +15 more

Design, Synthesis, and Evaluation of Potent, Selective, and Bioavailable AKT Kinase Degraders

Journal of Medicinal Chemistry(2021)10.1021/acs.jmedchem.1c01476

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54 citations

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