David M. Holtzman

Also affiliated with Hope Center for Neurological Disorders

MedicineNeuroscience

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 3%percentile

1.6Author DataRank

Indexed papers

3in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 3 indexed papers attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

The highest-impact dataset this researcher has shared, ranked by DataRank — the single contribution doing the most to lift their data-sharing standing.

Resting-State Functional Connectivity Disruption as a Pathological Biomarker in Autosomal Dominant Alzheimer Disease

Brain Connectivity(2021)10.1089/brain.2020.0808

Top 23%

0.874DataRank

Top 23%27 citations

Jeremy F. Strain, Aaron Tanenbaum, Anne M. Fagan, Jason Hassenstab, Eric McDade +27 more

Papers

Driven by 139 papers — median percentile 74. Top paper: “Longitudinal Associations of Blood Phosphorylated Tau181 and Neurofilament Light Chain With Neurodegeneration in Alzheimer Disease”.

Longitudinal Associations of Blood Phosphorylated Tau181 and Neurofilament Light Chain With Neurodegeneration in Alzheimer Disease

JAMA Neurology(2021)10.1001/jamaneurol.2020.4986

N/A

7.4DataRank · unranked

328 citations

Michel J. Grothe, Nicholas J. Ashton, Thomas K. Karikari, Juan Lantero‐Rodriguez, Anniina Snellman +79 more

Challenges and Opportunities with Causal Discovery Algorithms: Application to Alzheimer’s Pathophysiology

Scientific Reports(2020)10.1038/s41598-020-59669-x

N/A

4.4DataRank · unranked

136 citations

Sisi Ma, Prashanthi Vemuri, György Simon, the Alzheimer’s Disease Neuroimaging Initiative, Michael W. Weiner +95 more

Predicting brain age from functional connectivity in symptomatic and preclinical Alzheimer disease

NeuroImage(2022)10.1016/j.neuroimage.2022.119228

N/A

1.6DataRank · unranked

69 citations

Patrick H. Luckett, Brian A. Gordon, Tammie L.S. Benzinger, Suzanne E. Schindler, Anne M. Fagan +87 more

Deep learning-based polygenic risk analysis for Alzheimer’s disease prediction

Communications Medicine(2023)10.1038/s43856-023-00269-x

N/A

1.5DataRank · unranked

70 citations

Yu Chen, Fanny C.F. Ip, Yuanbing Jiang, Han Cao, Ge Lv +95 more

The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

Alzheimer's & Dementia(2011)10.1016/j.jalz.2011.03.008

N/A

1.4DataRank · unranked

10055 citations

Steven T. DeKosky, Bruno Dubois, Howard H. Feldman, Nick C. Fox, Anthony Gamst +11 more

Alternatives to amyloid for Alzheimer's disease therapies—a symposium report

Annals of the New York Academy of Sciences(2020)10.1111/nyas.14371

N/A

1.3DataRank · unranked

13 citations

David M. Holtzman, Bradley T. Hyman, Malú Gámez Tansey, Marco Colonna, Sharon L. R. Kardia +8 more

Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer's disease: an open-label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU trial

The Lancet Neurology(2025)10.1016/s1474-4422(25)00024-9

N/A

1.2DataRank · unranked

41 citations

Yan Li, Eric McDade, Jorge J. Llibre‐Guerra, David B. Clifford, Alireza Atri +62 more

FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease

Nature Communications(2020)10.1038/s41467-019-13962-0

N/A

1.2DataRank · unranked

33 citations

Jingjing Liang, Ju Gao, Luwen Wang, Hisashi Fujioka, The Alzheimer Disease Neuroimaging Initiative +92 more

Downstream Biomarker Effects of Gantenerumab or Solanezumab in Dominantly Inherited Alzheimer Disease

JAMA Neurology(2024)10.1001/jamaneurol.2024.0991

N/A

1.0DataRank · unranked

29 citations

Haiyan Liu, Guoqiao Wang, Xinyu Shi, Tobias Bittner, Marzia A. Scelsi +94 more

Cholesterol and matrisome pathways dysregulated in astrocytes and microglia

Cell(2022)10.1016/j.cell.2022.05.017

N/A

0.902DataRank · unranked

407 citations

Qian Lü, Nina H. Pipalia, Michael J. Chao, Shuang Liang, Yang Shi +16 more

Resting-State Functional Connectivity Disruption as a Pathological Biomarker in Autosomal Dominant Alzheimer Disease

Brain Connectivity(2021)10.1089/brain.2020.0808

Top 23%

0.874DataRank

Top 23%27 citations

Jeremy F. Strain, Aaron Tanenbaum, Anne M. Fagan, Jason Hassenstab, Eric McDade +27 more

Genome-wide association study identifies four novel loci associated with Alzheimer’s endophenotypes and disease modifiers

Acta Neuropathologica(2017)10.1007/s00401-017-1685-y

N/A

0.829DataRank · unranked

251 citations

Zeran Li, Manav Kapoor, Oscar Harari, Kathleen Black, David Carrell +44 more

APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints

Nature Immunology(2023)10.1038/s41590-023-01627-6

N/A

0.794DataRank · unranked

198 citations

Neta Rosenzweig, Kilian L. Kleemann, Xiaoming Zhang, Wesley Nogueira Brandão, Milica A. Margeta +38 more

Regional age-related atrophy after screening for preclinical alzheimer disease

Neurobiology of Aging(2021)10.1016/j.neurobiolaging.2021.09.010

N/A

0.703DataRank · unranked

24 citations

Pamela LaMontagne, Matthew F. Glasser, Randall J. Bateman, David M. Holtzman, Igor Yakushev +10 more

Genetic and multi-omic resources for Alzheimer disease and related dementia from the Knight Alzheimer Disease Research Center

Scientific Data(2024)10.1038/s41597-024-03485-9

Top 29%

0.695DataRank

Top 29%33 citations

Menghan Liu, Aleksandra Beric, Matt Johnson, Arda Cetin, Maulik Patel +38 more

A novel spatiotemporal graph convolutional network framework for functional connectivity biomarkers identification of Alzheimer’s disease

Alzheimer s Research & Therapy(2024)10.1186/s13195-024-01425-8

N/A

0.690DataRank · unranked

20 citations

Le Xue, Shuoyan Zhang, Jiacheng Yang, Qi Zhang, Min Wang +95 more

Predicting Symptom Onset in Sporadic Alzheimer Disease With Amyloid PET

Neurology(2021)10.1212/wnl.0000000000012775

N/A

0.688DataRank · unranked

97 citations

Yan Li, Virginia D. Buckles, Brian A. Gordon, Tammie L.S. Benzinger, Guoqiao Wang +8 more

Glucose metabolism in posterior cingulate cortex has supplementary value to predict the progression of cognitively unimpaired to dementia due to Alzheimer’s disease: an exploratory study of 18F-FDG-PET

GeroScience(2023)10.1007/s11357-023-00897-0

N/A

0.635DataRank · unranked

13 citations

Chunqiu Fan, Luyao Wang, Taoran Li, Min Wang, Ying Han +95 more

Regulation of astrocyte lipid metabolism and ApoE secretion by the microglial oxysterol, 25-hydroxycholesterol

Journal of Lipid Research(2023)10.1016/j.jlr.2023.100350

N/A

0.631DataRank · unranked

66 citations

Danira Toral-Ríos, David D. Timm, Johnathan Romero, Michael R. Strickland, Justin M. Long +4 more

Single-subject grey matter network trajectories over the disease course of autosomal dominant Alzheimer’s disease

Brain Communications(2020)10.1093/braincomms/fcaa102

N/A

0.464DataRank · unranked

21 citations

Ellen Dicks, Guoqiao Wang, Aylin Dincer, Shaney Flores, Sarah Keefe +81 more

ApoE-calypse tau: ApoE–tau synergy in Alzheimer’s disease

Journal of Experimental Medicine(2025)10.1084/jem.20250965

N/A

0.373DataRank · unranked

11 citations

Chiara Bordier, Léana Kamelher, Jason D. Ulrich, David M. Holtzman, Maud Gratuze +1 more

Baseline levels and longitudinal rates of change in plasma Aβ42/40 among self-identified Black/African American and White individuals

Research Square(2024)10.21203/rs.3.rs-3783571/v1

N/A

0.360DataRank · unranked

10 citations

Suzanne E. Schindler, Jingqin Luo, John C. Morris, Randall J. Bateman, David M. Holtzman +16 more

Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer’s disease: an open label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU Trial

medRxiv(2024)10.1101/2024.10.29.24316289

N/A

0.351DataRank · unranked

6 citations

Yan Li, Eric McDade, Jorge J. Llibre‐Guerra, David B. Clifford, Alireza Atri +63 more

Novel early‐onset Alzheimer‐associated genes influence risk through dysregulation of glutamate, immune activation, and intracellular signaling pathways

Alzheimer s & Dementia(2025)10.1002/alz.70377

N/A

0.312DataRank · unranked

7 citations

Cyril Pottier, Eder Lúcio da Fonseca, Jiji T. Kurup, Daniel Western, Ciyang Wang +22 more

ApoE Alzheimer’s Disease Aβ-amyloid plaque morphology varies according to APOE isotype

Research Square(2023)10.21203/rs.3.rs-2524641/v1

N/A

0.297DataRank · unranked

4 citations

K. Peter R. Nilsson, Per Hammarström, Mikaël Lindgren, Stefan Prokop, Frank L. Heppner +6 more

Characteristics of discordance between amyloid positron emission tomography and plasma amyloid-β 42/40 positivity

Translational Psychiatry(2024)10.1038/s41398-024-02766-6

N/A

0.241DataRank · unranked

4 citations

Young Ho Park, Young Chul Youn, Min Ju Kang, Kyu Hwan Shim, Jae‐Won Jang +73 more

Selective reduction of astrocyte apoE3 and apoE4 strongly reduces Aβ accumulation and plaque-related pathology in a mouse model of amyloidosis

Molecular Neurodegeneration(2022)10.1186/s13024-022-00516-0

N/A

0DataRank · unranked

137 citations

Chao Wang, Xin Bao, Ankit Choudhury, Jason D. Ulrich, David M. Holtzman +1 more

LRP1 is a neuronal receptor for α-synuclein uptake and spread

Molecular Neurodegeneration(2022)10.1186/s13024-022-00560-w

N/A

0DataRank · unranked

115 citations

Yuka A. Martens, Axel Meneses, Daniel Ryu, Wenyan Lü, Ana‐Caroline Raulin +14 more

TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4

Neuron(2022)10.1016/j.neuron.2022.10.022

N/A

0DataRank · unranked

114 citations

Johannes C. M. Schlachetzki, Ricardo D’Oliveira Albanus, Nimansha Jain, Brenna C. Novotny, Logan Brase +13 more

Recapitulation of endogenous 4R tau expression and formation of insoluble tau in directly reprogrammed human neurons

Cell stem cell(2022)10.1016/j.stem.2022.04.018

N/A

0DataRank · unranked

64 citations

Chihiro Sato, Elena Ficulle, Anan Yu, Kanta Horie, Ji‐Sun Kwon +11 more

A map of neurofilament light chain species in brain and cerebrospinal fluid and alterations in Alzheimer’s disease

Brain Communications(2022)10.1093/braincomms/fcac045

N/A

0DataRank · unranked

55 citations

Yingxin He, Nicolas R. Barthélemy, Hong Jiang, Yan Li, Ethan Park +5 more

APOE Antibody Inhibits Aβ‐Associated Tau Seeding and Spreading in a Mouse Model

Annals of Neurology(2022)10.1002/ana.26351

N/A

0DataRank · unranked

49 citations

Hong Jiang, Chanung Wang, Monica Xiong, Xin Bao, David M. Holtzman +1 more

Preclinical Alzheimer’s disease biomarkers accurately predict cognitive and neuropathological outcomes

Brain(2022)10.1093/brain/awac250

N/A

0DataRank · unranked

46 citations

Dean W. Coble, Johannes Levin, Suzanne E. Schindler, Richard J. Perrin, Brian A. Gordon +8 more

APOE ε4 genotype, amyloid-β, and sex interact to predict tau in regions of high APOE mRNA expression

Science Translational Medicine(2022)10.1126/scitranslmed.abl7646

N/A

0DataRank · unranked

42 citations

Charles D. Chen, Nicole S. McKay, Lauren N. Koenig, Austin McCullough, Shaney Flores +13 more

Using Alzheimer's disease blood tests to accelerate clinical trial enrollment

Alzheimer s & Dementia(2022)10.1002/alz.12754

N/A

0DataRank · unranked

39 citations

Yan Li, Melody Li, Alyssa Despotis, Ethan Park, Liberty Vittert +8 more

Adverse driving behaviors are associated with sleep apnea severity and age in cognitively normal older adults at risk for Alzheimer’s disease

SLEEP(2022)10.1093/sleep/zsac070

N/A

0DataRank · unranked

15 citations

Catherine M. Roe, Samantha Murphy, Ann M Johnson, Ella Fleischer, Cristina D. Toedebusch +9 more

Proteomic clusters underlie heterogeneity in preclinical Alzheimer’s disease progression

Brain(2022)10.1093/brain/awac484

N/A

0DataRank · unranked

11 citations

Omar H. Butt, Brian A. Gordon, Suzanne E. Schindler, Anne M. Fagan, Rachel L. Henson +8 more

Murine roseolovirus does not accelerate amyloid-β pathology and human roseoloviruses are not over-represented in Alzheimer disease brains

Molecular Neurodegeneration(2022)10.1186/s13024-021-00514-8

N/A

0DataRank · unranked

12 citations

Monica Xiong, Muhammad Ali, Yun Chen, Chao Wang, Javier Remolina Serrano +8 more

Systematic analysis of cellular crosstalk reveals a role for SEMA6D-TREM2 regulating microglial function in Alzheimer’s disease

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.11.11.516215

N/A

0DataRank · unranked

9 citations

Gina M. Finan, Logan Brase, Shuo Chen, Qi Guo, Abhirami Kannan +20 more

Phospholipase D3 contributes to Alzheimer’s disease risk via disruption of Aβ clearance and microglia response to amyloid plaques

medRxiv(2022)10.1101/2022.01.31.22270175

N/A

0DataRank · unranked

2 citations

Simon Hsu, Shih Feng You, Logan Brase, Anthony Verbeck, Rita Martinez +17 more

Proteomic Clusters Underlie Heterogeneity in Preclinical AD Progression

Research Square(2022)10.21203/rs.3.rs-1257861/v1

N/A

0DataRank · unranked

1 citations

Omar H. Butt, Brian A. Gordon, Suzanne E. Schindler, Anne M. Fagan, Chengran Yang +7 more

Proteomic Clusters Underlie Heterogeneity in Preclinical AD Progression

Research Square(2022)10.21203/rs.3.rs-1257861/v2

N/A

0DataRank · unranked

0 citations

Omar H. Butt, Brian A. Gordon, Suzanne E. Schindler, Anne M. Fagan, Chengran Yang +7 more

Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer's disease

Research Square(2022)10.21203/rs.3.rs-2208663/v1

N/A

0DataRank · unranked

0 citations

Emily E. Prescott, Hollie Wareing, Martyna M. Matuszyk, Helen Dakin, Eleni Dimou +20 more

Hallmarks of neurodegenerative diseases

Cell(2023)10.1016/j.cell.2022.12.032

N/A

0DataRank · unranked

1684 citations

Mark Cookson, Ludo Van Den Bosch, Henrik Zetterberg, David M. Holtzman, Ilse Dewachter +1 more

Gut microbiome composition may be an indicator of preclinical Alzheimer’s disease

Science Translational Medicine(2023)10.1126/scitranslmed.abo2984

N/A

0DataRank · unranked

339 citations

JooHee Choi, Jian Ryou, Erin Newcomer, Regina Thompson, Rebecca M. Bollinger +15 more

ApoE isoform– and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy

Science(2023)10.1126/science.add1236

N/A

0DataRank · unranked

247 citations

David O’Donnell, Nimansha Jain, Jason D. Ulrich, Jasmin Herz, Yuhao Li +18 more

Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist

Neuron(2023)10.1016/j.neuron.2023.10.023

N/A

0DataRank · unranked

138 citations

Jung H. Suh, Jing Guo, Karin Lin, Sonnet S. Davis, Nga Bien‐Ly +14 more

Sleep deprivation exacerbates microglial reactivity and Aβ deposition in a TREM2 -dependent manner in mice

Science Translational Medicine(2023)10.1126/scitranslmed.ade6285

N/A

0DataRank · unranked

123 citations

Grace Gent, Yun Chen, Nicholas Rensing, Maud Gratuze, Gregory W. Strout +19 more

APOE3ch alters microglial response and suppresses Aβ-induced tau seeding and spread

Cell(2023)10.1016/j.cell.2023.11.029

N/A

0DataRank · unranked

116 citations

Sihui Song, Samira Parhizkar, Jennifer Lord, Yiyang Zhu, Michael R. Strickland +11 more

TREM2 inhibition triggers antitumor cell activity of myeloid cells in glioblastoma

Science Advances(2023)10.1126/sciadv.ade3559

N/A

0DataRank · unranked

114 citations

Rowland H. Han, Colin McCornack, Saad M. Khan, G. Travis Tabor, Yun Chen +14 more

APOE-ε4 synergizes with sleep disruption to accelerate Aβ deposition and Aβ-associated tau seeding and spreading

Journal of Clinical Investigation(2023)10.1172/jci169131

N/A

0DataRank · unranked

57 citations

Aishwarya Nambiar, Michael R. Strickland, Choonghee Lee, Samira Parhizkar, A Moore +4 more

Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy

Molecular Neurodegeneration(2023)10.1186/s13024-023-00610-x

N/A

0DataRank · unranked

35 citations

Chao Wang, Maud Gratuze, Fareeha Saadi, Xin Bao, Megan E. Bosch +7 more

Mapping sleep's oscillatory events as a biomarker of Alzheimer's disease

Alzheimer s & Dementia(2023)10.1002/alz.13420

N/A

0DataRank · unranked

30 citations

Eugene Kronberg, Lindsey M. Medenblik, Vitaly O. Kheyfets, Alberto R. Ramos, David M. Holtzman +7 more

KATP channels are necessary for glucose-dependent increases in amyloid-β and Alzheimer’s disease–related pathology

JCI Insight(2023)10.1172/jci.insight.162454

N/A

0DataRank · unranked

27 citations

William R. Moritz, Morgan C. Pait, Molly Stanley, Sarah Kaye, Caitlin M. Carroll +17 more

Brain network decoupling with increased serum neurofilament and reduced cognitive function in Alzheimer’s disease

Brain(2023)10.1093/brain/awac498

N/A

0DataRank · unranked

30 citations

Jeremy F. Strain, Patricia K. Mansfield, Jiaxin Cindy Tu, Aaron Tanenbaum, Oliver Preische +85 more

Parenchymal border macrophages regulate tau pathology and tau-mediated neurodegeneration

Life Science Alliance(2023)10.26508/lsa.202302087

N/A

0DataRank · unranked

24 citations

Siling Du, Michal Kipnis, Megan E. Bosch, Jasmin Herz, Choonghee Lee +7 more

Mapping Sleep’s Oscillatory Events as a Biomarker of Alzheimer’s Disease

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.02.15.528725

N/A

0DataRank · unranked

2 citations

Eugene Kronberg, Lindsey M. Medenblik, Vitaly O. Kheyfets, Alberto R. Ramos, David M. Holtzman +7 more

Endogenous recapitulation of Alzheimer’s disease neuropathology through human 3D direct neuronal reprogramming

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.05.24.542155

N/A

0DataRank · unranked

10 citations

Ji‐Sun Kwon, Yudong Ren, Shawei Chen, K. Lynn Cates, Xinguo Lu +16 more

Cell autonomous role of border associated macrophages in ApoE4 neurovascular dysfunction and susceptibility to white matter injury

Research Square(2023)10.21203/rs.3.rs-3222611/v1

N/A

0DataRank · unranked

8 citations

Antoine Anfray, Samantha Schaeffer, Yorito Hattori, Monica M. Santisteban, Nicole Casey +7 more

APOE2 gene therapy reduces amyloid deposition, and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.08.14.552850

N/A

0DataRank · unranked

7 citations

Megan S. Keiser, Jonah C Meltzer, Dustin P. Fykstra, Steven E. Dierksmeier, Alexandra Melloni +9 more

Chronotype is Associated with Sleep Quality in Older Adults

medRxiv(2023)10.1101/2023.09.04.23294997

N/A

0DataRank · unranked

5 citations

Cristina D. Toedebusch, Rachel Richardson, Adam P. Spira, John C. Morris, David M. Holtzman +2 more

Tauopathy severely disrupts homeostatic set-points in emergent neural dynamics but not in the activity of individual neurons

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.09.01.555947

N/A

0DataRank · unranked

3 citations

Clayton A. Farris, Sahara Ensley, Aidan Schneider, Chao Wang, Yuqi Liu +9 more

Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis, and reactive microglia in a dose- and sex-specific manner

Research Square(2023)10.21203/rs.3.rs-3394003/v1

N/A

0DataRank · unranked

1 citations

Hemraj B. Dodiya, Julia Michalkiewicz, Choonghee Lee, Shabana M. Shaik, Ian Q. Weigle +18 more

Standardized immunoprecipitation protocol for efficient isolation of native apolipoprotein E particles utilizing HJ15.4 monoclonal antibody

STAR Protocols(2023)10.1016/j.xpro.2023.102271

N/A

0DataRank · unranked

0 citations

Ana‐Caroline Raulin, Zonghua Li, Yuka A. Martens, Yasuteru Inoue, Michael R. Strickland +5 more

Current understanding of the Alzheimer’s disease-associated microbiome and therapeutic strategies

Experimental & Molecular Medicine(2024)10.1038/s12276-023-01146-2

N/A

0DataRank · unranked

211 citations

David M. Holtzman, Dong-oh Seo

Clinical validation of the PrecivityAD2 blood test: A mass spectrometry‐based test with algorithm combining %p‐tau217 and Aβ42/40 ratio to identify presence of brain amyloid

Alzheimer s & Dementia(2024)10.1002/alz.13764

N/A

0DataRank · unranked

112 citations

Kristopher M. Kirmess, Stephanie Eastwood, Traci L. Wente‐Roth, Faith Irvin, Mary S. Holubasch +20 more

Timing of Biomarker Changes in Sporadic Alzheimer's Disease in Estimated Years from Symptom Onset

Annals of Neurology(2024)10.1002/ana.26891

N/A

0DataRank · unranked

88 citations

Daniel Yen, Rachel Hendrix, Brian A. Gordon, Sibonginkhosi L. Dlamini, Nicolas R. Barthélemy +17 more

Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes

Cell(2024)10.1016/j.cell.2024.10.027

N/A

0DataRank · unranked

86 citations

Dylan Braun, Gabriel A. Fitzgerald, Yun-Ting Hsieh, Lionel Rougé, Alexandra Litvinchuk +37 more

APOE2 gene therapy reduces amyloid deposition and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease

Molecular Therapy(2024)10.1016/j.ymthe.2024.03.024

N/A

0DataRank · unranked

70 citations

Megan S. Keiser, Jonah C Meltzer, Dustin P. Fykstra, Steven E. Dierksmeier, Soroush Hajizadeh +14 more

[O1–11–03]: CEREBROSPINAL FLUID ENDOPHENOTYPES PROVIDE INSIGHT INTO BIOLOGY UNDERLYING ALZHEIMER'S DISEASE

Alzheimer's & Dementia(2017)10.1016/j.jalz.2017.07.096

N/A

0DataRank · unranked

0 citations

Manav Kapoor, Zeran Li, Oscar Harari, Kathleen Black, Jorge L. Del‐Aguila +53 more

Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer’s disease

Nature Communications(2024)10.1038/s41467-024-49028-z

N/A

0DataRank · unranked

60 citations

Emily E. Prescott, Agnieszka Urbanek, Hollie Wareing, Marianne C. King, Anna Olerinyova +26 more

Alzheimer’s disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model

Neuron(2024)10.1016/j.neuron.2024.09.006

N/A

0DataRank · unranked

60 citations

Li Fan, Nessa Foxe, Kendra Norman, Man Ying Wong, Daphne Zhu +25 more

Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner

Molecular Neurodegeneration(2024)10.1186/s13024-023-00700-w

N/A

0DataRank · unranked

59 citations

Hemraj B. Dodiya, Julia Michalkiewicz, Choonghee Lee, Shabana M. Shaik, Ian Q. Weigle +18 more

Aducanumab anti-amyloid immunotherapy induces sustained microglial and immune alterations

The Journal of Experimental Medicine(2024)10.1084/jem.20231363

N/A

0DataRank · unranked

55 citations

Katelin A. Gibson, Kennedi T. Todd, David Nascari, Nashali Massa, Meredith T. Lilley +6 more

A cell-autonomous role for border-associated macrophages in ApoE4 neurovascular dysfunction and susceptibility to white matter injury

Nature Neuroscience(2024)10.1038/s41593-024-01757-6

N/A

0DataRank · unranked

45 citations

Samantha Schaeffer, Yorito Hattori, Monica M. Santisteban, Nicole Casey, Gang Wang +7 more

Antibody-mediated targeting of human microglial leukocyte Ig-like receptor B4 attenuates amyloid pathology in a mouse model

Science Translational Medicine(2024)10.1126/scitranslmed.adj9052

N/A

0DataRank · unranked

44 citations

Yun Chen, Zhangying Cai, Gyu Seong Heo, Carla M. Yuede, Z Wang +21 more

Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy

The Journal of Experimental Medicine(2024)10.1084/jem.20232000

N/A

0DataRank · unranked

41 citations

Justin M. Long, Jason D. Ulrich, Jinsheng Yu, Michael R. Strickland, Xianlin Han +4 more

CSF biomarkers of immune activation and Alzheimer’s disease for predicting cognitive impairment risk in the elderly

Science Advances(2024)10.1126/sciadv.adk3674

N/A

0DataRank · unranked

33 citations

Launia J. White, Rachel Hendrix, Jason D. Ulrich, Rachel L. Henson, William D. Knight +19 more

Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference

Alzheimer s & Dementia(2024)10.1002/alz.13877

N/A

0DataRank · unranked

33 citations

Michaël E. Belloy, Elizabeth Blue, Gregory R. Bowman, María C. Carrillo, Xiaoying Chen +55 more

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