Guojun Bu

Hong Kong University of Science and Technology

Also affiliated with WinnMed, Hong Kong Jockey Club, University of Hong Kong

MedicineNeuroscienceBiochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

3in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 3 indexed papers attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

Papers

Driven by 67 papers. Top paper: “Performance of plasma phosphorylated tau 181 and 217 in the community”.

Performance of plasma phosphorylated tau 181 and 217 in the community

Nature Medicine(2022)10.1038/s41591-022-01822-2

N/A

11.9DataRank · unranked

498 citations

Jeffrey L. Dage, Ryan D. Frank, Alicia Algeciras‐Schimnich, David S. Knopman, Val J. Lowe +6 more

APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids

Nature Communications(2020)10.1038/s41467-020-19264-0

N/A

7.4DataRank · unranked

377 citations

Yuan Fu, Yu Yamazaki, Yingxue Ren, Mary Dabney Davis, Chia‐Chen Liu +18 more

APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid

Science Translational Medicine(2020)10.1126/scitranslmed.aay1809

N/A

5.1DataRank · unranked

165 citations

Olivia N. Attrebi, Yingxue Ren, Wenhui Qiao, Berkiye Sonustun, Yuka A. Martens +19 more

Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Mediates Neuronal Aβ42 Uptake and Lysosomal Trafficking

PLoS ONE(2010)10.1371/journal.pone.0011884

N/A

4.1DataRank · unranked

111 citations

Qiang Liu, Juan Zhang, Takahisa Kanekiyo, Xiaoyan Hu, Jin-Moo Lee +3 more

Loss of TMEM106B leads to myelination deficits: implications for frontotemporal dementia treatment strategies

Brain(2020)10.1093/brain/awaa141

N/A

2.1DataRank · unranked

79 citations

Alexandra M. Nicholson, Yingxue Ren, Mieu Brooks, Peizhou Jiang, Aamir Zuberi +17 more

Sex specific molecular networks and key drivers of Alzheimer’s disease

Molecular Neurodegeneration(2023)10.1186/s13024-023-00624-5

N/A

1.2DataRank · unranked

48 citations

Jiqing Cao, Jianwei Hou, Yonghe Li, Min Huang, Li Zhu +14 more

Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference

Alzheimer s & Dementia(2024)10.1002/alz.13877

N/A

1.1DataRank · unranked

33 citations

Michaël E. Belloy, Elizabeth Blue, Gregory R. Bowman, María C. Carrillo, Xiaoying Chen +55 more

ABCA7 deficiency causes neuronal dysregulation by altering mitochondrial lipid metabolism

Molecular Psychiatry(2023)10.1038/s41380-023-02372-w

N/A

1.1DataRank · unranked

51 citations

Marie‐Louise Holm, Skylar C Starling, Yuka A. Martens, Jing Zhao, Wenyan Lü +14 more

ApoE in Alzheimer’s disease: pathophysiology and therapeutic strategies

Molecular Neurodegeneration(2022)10.1186/s13024-022-00574-4

N/A

0.988DataRank · unranked

722 citations

Sydney V. Doss, Zachary A. Trottier, Tadafumi C. Ikezu, Guojun Bu, Chia‐Chen Liu +1 more

APOE deficiency impacts neural differentiation and cholesterol biosynthesis in human iPSC-derived cerebral organoids

Stem Cell Research & Therapy(2023)10.1186/s13287-023-03444-y

N/A

0.891DataRank · unranked

23 citations

Tadafumi C. Ikezu, Wenyan Lü, Jesse R. Macyczko, Yonghe Li, Laura J. Lewis‐Tuffin +8 more

TDP-43 Pathology in Alzheimer’s Disease

Molecular Neurodegeneration(2021)10.1186/s13024-021-00503-x

N/A

0.890DataRank · unranked

377 citations

Shunsuke Koga, Justin O’Leary, Dennis W. Dickson, Guojun Bu, Na Zhao +1 more

A reference human induced pluripotent stem cell line for large-scale collaborative studies

Cell stem cell(2022)10.1016/j.stem.2022.11.004

N/A

0.860DataRank · unranked

308 citations

Andrian Yang, Erika Lara, Justin A. McDonough, Cornelis Blauwendraat, Lirong Peng +90 more

CSF biomarkers of immune activation and Alzheimer’s disease for predicting cognitive impairment risk in the elderly

Science Advances(2024)10.1126/sciadv.adk3674

N/A

0.851DataRank · unranked

33 citations

Launia J. White, Rachel Hendrix, Jason D. Ulrich, Rachel L. Henson, William D. Knight +19 more

Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer’s disease

Nature Immunology(2023)10.1038/s41590-023-01640-9

N/A

0.752DataRank · unranked

149 citations

Na Wang, Yuanxin Chen, Yasuteru Inoue, Francis Shue, Yingxue Ren +24 more

LRP1 in vascular mural cells modulates cerebrovascular integrity and function in the presence of APOE4

JCI Insight(2023)10.1172/jci.insight.163822

N/A

0.749DataRank · unranked

24 citations

Yu Yamazaki, Wenhui Qiao, Chen Yuanxin, Yingxue Ren, Aishe Kurti +18 more

DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response

Journal of Biological Chemistry(2015)10.1074/jbc.m115.645986

N/A

0.734DataRank · unranked

132 citations

Xiao-Fen Chen, Zhen-Lian Zhang, Zhe Wang, Xin-Zhen Shi, Kai Xu +4 more

Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia

The Journal of Experimental Medicine(2022)10.1084/jem.20212479

N/A

0.730DataRank · unranked

129 citations

Wenhui Qiao, Fuyao Li, Yingxue Ren, Jiaying Zheng, Yuka A. Martens +26 more

Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination

Molecular Neurodegeneration(2022)10.1186/s13024-022-00577-1

N/A

0.661DataRank · unranked

81 citations

Minghui Wang, Suren Jeevaratnam, Cassandra L. Rosenberg, Tadafumi C. Ikezu, Francis Shue +9 more

APOE4 exacerbates α-synuclein seeding activity and contributes to neurotoxicity in Alzheimer’s disease with Lewy body pathology

Acta Neuropathologica(2022)10.1007/s00401-022-02421-8

N/A

0.646DataRank · unranked

73 citations

Fuyao Li, Berkiye Sonoustoun, Naveen Kondru, Yuka A. Martens, Wenhui Qiao +14 more

Loss of Tmem106b exacerbates FTLD pathologies and causes motor deficits in progranulin‐deficient mice

EMBO Reports(2020)10.15252/embr.202050197

N/A

0.635DataRank · unranked

68 citations

Mieu Brooks, Peizhou Jiang, Shunsuke Koga, Aamir Zuberi, Matthew Baker +11 more

Sensitive ELISA-based detection method for the mitophagy marker p-S65-Ub in human cells, autopsy brain, and blood samples

Autophagy(2020)10.1080/15548627.2020.1834712

N/A

0.631DataRank · unranked

66 citations

Xu Hou, Dominika Fričová, Chloe Ramnarine, Sandeep Kumar Barodia, Tania F. Gendron +12 more

Apolipoprotein E regulates lipid metabolism and α-synuclein pathology in human iPSC-derived cerebral organoids

Acta Neuropathologica(2021)10.1007/s00401-021-02361-9

N/A

0.614DataRank · unranked

59 citations

Wenyan Lü, Yingxue Ren, Yuan Fu, Yuka A. Martens, Francis Shue +18 more

APOE and immunity: Research highlights

Alzheimer s & Dementia(2023)10.1002/alz.13020

N/A

0.533DataRank · unranked

34 citations

Christopher J. Barnum, André F. Batista, Elizabeth M. Bradshaw, Adam M. Brickman, Guojun Bu +35 more

Genome-wide association study of brain biochemical phenotypes reveals distinct genetic architecture of Alzheimer’s disease related proteins

Molecular Neurodegeneration(2023)10.1186/s13024-022-00592-2

N/A

0.500DataRank · unranked

27 citations

Joseph S. Reddy, Zachary Quicksall, Minerva M. Carrasquillo, Xue Wang, Chia‐Chen Liu +22 more

APOEgenotypes modify the obesity paradox in dementia

Journal of Neurology Neurosurgery & Psychiatry(2023)10.1136/jnnp-2022-331034

N/A

0.489DataRank · unranked

25 citations

Ghupurjan Gheni, Junichi Hitomi, Guojun Bu, Naoyuki Sato, Mitsuru Shinohara

A reference induced pluripotent stem cell line for large-scale collaborative studies

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.12.15.472643

N/A

0.467DataRank · unranked

14 citations

Andrian Yang, Erika Lara, Justin A. McDonough, Cornelis Blauwendraat, Lirong Peng +90 more

Independent and Cooperative Roles of N-Glycans and Molecular Chaperones in the Folding and Disulfide Bond Formation of the Low-Density Lipoprotein (LDL) Receptor-Related Protein

Biochemistry(2005)10.1021/bi047652a

N/A

0.442DataRank · unranked

18 citations

Reiko Urade, Yukino Arakaki, Alan L. Schwartz, Guojun Bu, Lynn M. McCormick

The UFMylation pathway is impaired in Alzheimer’s disease

Molecular Neurodegeneration(2024)10.1186/s13024-024-00784-y

N/A

0.434DataRank · unranked

17 citations

Michael G. Heckman, Emily C. Craver, Chia‐Chen Liu, Bailey Rawlinson, Xue Wang +8 more

Loss of Tmem106b leads to cerebellum Purkinje cell death and motor deficits

Brain Pathology(2021)10.1111/bpa.12945

N/A

0.425DataRank · unranked

16 citations

Alexandra M. Nicholson, Yingxue Ren, Shunsuke Koga, Hung Phuoc Nguyen, Mieu Brooks +18 more

Impact of APOE on amyloid and tau accumulation in argyrophilic grain disease and Alzheimer’s disease

Acta Neuropathologica Communications(2024)10.1186/s40478-024-01731-0

N/A

0.406DataRank · unranked

14 citations

Sydney V. Doss, Michael G. Heckman, Emily C. Craver, Zonghua Li, Tadafumi C. Ikezu +17 more

Probe-dependent Proximity Profiling (ProPPr) Uncovers Similarities and Differences in Phospho-Tau-Associated Proteomes Between Tauopathies

Molecular Neurodegeneration(2025)10.1186/s13024-025-00817-0

N/A

0.373DataRank · unranked

11 citations

Melissa C. Wren, Feilin Liu, Naomi Kouri, Anastasiia Maistrenko, Bilal Khalil +9 more

A TREM2 antibody energizes microglia

Nature Neuroscience(2023)10.1038/s41593-023-01265-z

N/A

0.360DataRank · unranked

10 citations

Guojun Bu, Na Zhao

Generation and validation of APOE knockout human iPSC-derived cerebral organoids

STAR Protocols(2021)10.1016/j.xpro.2021.100571

N/A

0.360DataRank · unranked

10 citations

Siming Xu, Richard JR Tait, Gang Li, Xin-Ping Zhao, Wenyan Lü +5 more

APOE2 Exacerbates TDP‐43 Related Toxicity in the Absence of Alzheimer Pathology

Annals of Neurology(2022)10.1002/ana.26580

N/A

0.345DataRank · unranked

9 citations

Shunsuke Koga, Zonghua Li, Justin O’Leary, Fuyao Li, Kai Chen +23 more

An assay to evaluate the capacity of cholesterol acceptors using BODIPY-cholesterol in cells

STAR Protocols(2023)10.1016/j.xpro.2022.101976

N/A

0.325DataRank · unranked

5 citations

Chia‐Chen Liu, Guojun Bu, Ana‐Caroline Raulin

Genome‐wide association analysis identifies APOE as a mitophagy modifier in Lewy body disease

Alzheimer s & Dementia(2025)10.1002/alz.70198

N/A

0.312DataRank · unranked

7 citations

Michael G. Heckman, Fabienne C. Fiesel, Shunsuke Koga, Alexandra I. Soto‐Beasley, Jens O. Watzlawik +14 more

Alzheimer's disease risk ABCA7 p.A696S variant disturbs the microglial response to amyloid pathology in mice

Neurobiology of Disease(2025)10.1016/j.nbd.2025.106813

N/A

0.312DataRank · unranked

7 citations

Dmitry Prokopenko, Ni Wang, Tomonori Aikawa, Younjung Choi, Can Zhang +17 more

Impact of APOE on cerebrovascular lipid profile in Alzheimer’s disease

Acta Neuropathologica(2025)10.1007/s00401-025-02949-5

N/A

0.292DataRank · unranked

6 citations

Hu Wang, Michael G. Heckman, Yingxue Ren, Launia J. White, Wenyan Lü +12 more

Genome-wide association study identifies APOE and ZMIZ1 variants as mitophagy modifiers in Lewy body disease

medRxiv(2023)10.1101/2023.10.16.23297100

N/A

0.269DataRank · unranked

5 citations

Michael G. Heckman, Fabienne C. Fiesel, Shunsuke Koga, Alexandra I. Soto‐Beasley, Jens O. Watzlawik +14 more

Cerebral hypoperfusion reduces tau accumulation

Annals of Clinical and Translational Neurology(2024)10.1002/acn3.52247

N/A

0.208DataRank · unranked

3 citations

Mitsuru Shinohara, Masami Masuda‐Suzukake, Akihiko Shindo, Atsushi Watanabe, Kaori Kawai +5 more

MicroED as a powerful tool for structure determination of macrocyclic drug compounds directly from their powder formulations

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.07.31.551405

N/A

0.165DataRank · unranked

2 citations

Guojun Bu, Hermina Wieske, Tamir Gonen, Emma Danelius

Polymorphic Structure Determination of the Macrocyclic Drug Paritaprevir by MicroED

ProQuest LLC eBooks(2023)10.1101/2023.09.09.556999

N/A

0DataRank · unranked

2 citations

Emma Danelius, Lianne H. E. Wieske, Tamir Gonen, Guojun Bu

Data from Low-Density Lipoprotein Receptor-Related Protein 1 Promotes Cancer Cell Migration and Invasion by Inducing the Expression of Matrix Metalloproteinases 2 and 9

(2023)10.1158/0008-5472.c.6499641.v1

N/A

0DataRank · unranked

0 citations

Yonghe Li, Jiyeon Lee, Alan L. Schwartz, Guojun Bu, Heesang Song

Standardized immunoprecipitation protocol for efficient isolation of native apolipoprotein E particles utilizing HJ15.4 monoclonal antibody

STAR Protocols(2023)10.1016/j.xpro.2023.102271

N/A

0DataRank · unranked

0 citations

Ana‐Caroline Raulin, Zonghua Li, Yuka A. Martens, Yasuteru Inoue, Michael R. Strickland +5 more

Therapeutic potential of human microglia transplantation in a chimeric model of CSF1R-related leukoencephalopathy

Neuron(2024)10.1016/j.neuron.2024.05.023

N/A

0DataRank · unranked

78 citations

Jonathan Hasselmann, Alina Lahian, Joia Kai Capocchi, Adrian Escobar, Tau En Lim +14 more

LRP1-Dependent Endocytic Mechanism Governs the Signaling Output of the Bmp System in Endothelial Cells and in Angiogenesis

UNC Libraries(2020)10.17615/c5k9-y357

N/A

0DataRank · unranked

1 citations

Edward J. Flynn, Andrea L. Portbury, Cam Patterson, Martin Moser, Guojun Bu +7 more

Astrocyte-derived clusterin suppresses amyloid formation in vivo

Molecular Neurodegeneration(2020)10.1186/s13024-020-00416-1

N/A

0DataRank · unranked

68 citations

Jonathon Sens, Silvia S. Kang, Kelsey E. Baker, Taylor J. Berry, Aishe Kurti +8 more

Amyloid pathology and cognitive impairment in hAβ-KI and APPSAA-KI mouse models of Alzheimer's disease

Neurobiology of Aging(2024)10.1016/j.neurobiolaging.2024.10.005

N/A

0DataRank · unranked

7 citations

Francis Shue, Aishe Kurti, Suren Jeevaratnam, Jesse R. Macyczko, Bhaskar Roy +6 more

APOE genotype determines cell-type-specific pathological landscape of Alzheimer’s disease

Neuron(2025)10.1016/j.neuron.2025.02.017

N/A

0DataRank · unranked

29 citations

Yuka A. Martens, Yingxue Ren, Yunjung Jin, Hiroaki Sekiya, Sydney V. Doss +25 more

Enhancing TREM2 expression activates microglia and modestly mitigates tau pathology and neurodegeneration

Journal of Neuroinflammation(2025)10.1186/s12974-025-03420-8

N/A

0DataRank · unranked

20 citations

Fuyao Li, Shuwen Zhang, Yixing Chen, Tadafumi C. Ikezu, Zonghua Li +8 more

Neuronal ABCA7 deficiency aggravates mitochondrial dysfunction and neurodegeneration in Alzheimer's disease

Alzheimer s & Dementia(2025)10.1002/alz.70112

N/A

0DataRank · unranked

5 citations

Yining Pan, Skylar C Starling, Devon H. Haskell, Astrid Quintero, Keiji Kawatani +18 more

Vascular ApoE4 Impairs Behavior by Modulating Gliovascular Function

Neuron(2020)10.1016/j.neuron.2020.11.019

N/A

0DataRank · unranked

74 citations

Chia‐Chen Liu, Akari Yamazaki, Francis Shue, Yuka A. Martens, Yuanxin Chen +13 more

Suppression of Wnt/β-Catenin Signaling Is Associated with Downregulation of Wnt1, PORCN, and Rspo2 in Alzheimer’s Disease

Molecular Neurobiology(2022)10.1007/s12035-022-03065-1

N/A

0DataRank · unranked

22 citations

Na Wang, Jing Zhao, Yingxue Ren, Wenyan Lü, Tadafumi C. Ikezu +5 more

APOE2: protective mechanism and therapeutic implications for Alzheimer’s disease

Molecular Neurodegeneration(2020)10.1186/s13024-020-00413-4

N/A

0DataRank · unranked

315 citations

Francis Shue, Na Zhao, Mitsuru Shinohara, Guojun Bu, Zonghua Li

Effects of Microglia APOE Expression on Tau Pathology

The FASEB Journal(2022)10.1096/fasebj.2022.36.s1.r4949

N/A

0DataRank · unranked

1 citations

Na Wang, Guojun Bu, Chia‐Chen Liu, Samantha K. Baker

APOE deficiency impacts neural differentiation and cholesterol biosynthesis in human iPSC-derived cerebral organoids

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.06.30.498241

N/A

0DataRank · unranked

1 citations

Tadafumi C. Ikezu, Wenyan Lü, Jesse R. Macyczko, Yonghe Li, Laura J. Lewis‐Tuffin +8 more

Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer’s disease

Molecular Neurodegeneration(2023)10.1186/s13024-023-00640-5

N/A

0DataRank · unranked

300 citations

Francis Shue, Guojun Bu, Takahisa Kanekiyo, Yasuteru Inoue

LRP1 is a neuronal receptor for α-synuclein uptake and spread

Molecular Neurodegeneration(2022)10.1186/s13024-022-00560-w

N/A

0DataRank · unranked

115 citations

Yuka A. Martens, Axel Meneses, Daniel Ryu, Wenyan Lü, Ana‐Caroline Raulin +14 more

Pushing the boundaries of brain organoids to study Alzheimer’s disease

Trends in Molecular Medicine(2023)10.1016/j.molmed.2023.05.007

N/A

0DataRank · unranked

56 citations

Guojun Bu, Yanhong Shi, Jonas Cerneckis

TREM2-H157Y Increases Soluble TREM2 Production and Reduces Amyloid Pathology

Research Square(2021)10.21203/rs.3.rs-960300/v1

N/A

0DataRank · unranked

0 citations

Yixing Chen, Yuka A. Martens, Chia‐Chen Liu, Joshua A. Knight, Fuyao Li +8 more

TREM2-H157Y Increases Soluble TREM2 Production and Reduces Amyloid Pathology

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.10.04.463020

N/A

0DataRank · unranked

1 citations

Yixing Chen, Yuka A. Martens, Chia‐Chen Liu, Joshua A. Knight, Fuyao Li +8 more

Preparation of single cell suspensions enriched in mouse brain vascular cells for single-cell RNA sequencing

STAR Protocols(2021)10.1016/j.xpro.2021.100715

N/A

0DataRank · unranked

5 citations

Francis Shue, Yu Yamazaki, Yuka A. Martens, Guojun Bu, Chia‐Chen Liu +1 more

ABCA7 Regulates Brain Fatty Acid Metabolism During LPS-Induced Acute Inflammation

Frontiers in Neuroscience(2021)10.3389/fnins.2021.647974

N/A

0DataRank · unranked

25 citations

Yingxue Ren, Marie‐Louise Holm, Yan W. Asmann, Amer Alam, Michael L. Fitzgerald +3 more

Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology

Molecular Neurodegeneration(2023)10.1186/s13024-023-00599-3

N/A

0DataRank · unranked

24 citations

Yixing Chen, Jun Zhong, Benjamin J. Madden, M. Cristine Charlesworth, Yuka A. Martens +18 more

APOE2 promotes longevity independent of Alzheimer’s disease

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.08.31.255141

N/A

0DataRank · unranked

0 citations

Takahisa Kanekiyo, Masaya Tachibana, Aishe Kurti, Motoko Shinohara, Yuan Fu +8 more

Diagnostic Utility of Cerebrospinal Fluid Biomarkers in Patients with Rapidly Progressive Dementia

Annals of Neurology(2023)10.1002/ana.26822

N/A

0DataRank · unranked

16 citations

Philip W. Tipton, Yuka A. Martens, Matthew R. Brier, Nihal Satyadev, Steven Dunham +11 more

Upregulation of sFRP1 Is More Profound in Female than Male 5xFAD Mice and Positively Associated with Amyloid Pathology

Journal of Alzheimer s Disease(2023)10.3233/jad-230218

N/A

0DataRank · unranked

12 citations

Na Wang, Wenyan Lü, Suren Jeevaratnam, Francis Shue, Yuka A. Martens +5 more