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A gene regulatory network approach harmonizes genetic and epigenetic signals and reveals repurposable drug candidates for multiple sclerosis

Human Molecular Genetics(2022)10.1093/hmg/ddac265Source: DataRank Database

A gene regulatory network approach harmonizes genetic and epigenetic signals and reveals repurposable drug candidates for multiple sclerosis is a research paper published in Human Molecular Genetics (2022). On theSindex it has a DataRank of 0. It has been cited 19 times.

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Open Access19 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (9 grants)Impact (FWCI 2.59)OA: greenTopics (40)Linked Datasets (20)DataCite Reuse (20)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (2/2)

Has DOI
Indexed in repositories

Accessible (1/2)

Open Access

Interoperable (2/2)

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Linked datasets

Reusable (0/3)

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Authors (5)

Yulin Dai ORCID,Peilin Jia ORCID,Léorah Freeman ORCID,Zhongming Zhao ORCID,Astrid M. Manuel ORCID

Live enrichment

PubMed:36282535 PMC:PMC9991005 OpenAlex:https://openalex.org/W4307233322

National Institutes of Health

Grant: R01LM012806

National Institutes of Health

Grant: R01DE029818

National Institutes of Health

Grant: R01DE030122

Cancer Prevention and Research Institute of Texas

Grant: RP180734

Cancer Prevention and Research Institute of Texas

Grant: RP210045

National Library of Medicine Training Program

Grant: T15LM007093

National Institutes of Health

Grant: 1R01LM012806-01

Predicting Phenotype by Using Transcriptomic Alteration as Endophenotype

National Institutes of Health

Grant: 5R01DE029818-03

Role of cellular metabolism in palate morphogenesis

National Institutes of Health

Grant: 5R01DE030122-03

Deep learning for decoding genetic regulation and cellular maps in craniofacial development

FWCI

2.59

Citation Percentile

0.9%

Citation Trend

2023

2024

2025

greenLicense: OUP Standard Publication Reuse

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/9991005

GREENhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9991005

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/9991005

publisherhttps://academic.oup.com/hmg/advance-article-pdf/doi/10.1093/hmg/ddac265/47264702/ddac265.pdf

publisherhttps://academic.oup.com/hmg/article-pdf/32/6/998/49433865/ddac265.pdf

Fields of Study

Bioinformatics and Genomic NetworksMultiple Sclerosis Research StudiesEpigenetics and DNA MethylationMedicineBiology0301 basic medicine0303 health sciences03 medical and health sciencesHumansEpigenesis, GeneticGene Regulatory NetworksGenome-Wide Association StudyMultiple SclerosisDNA MethylationQuantitative Trait Loci

MeSH Terms

HumansMultiple SclerosisDNA MethylationQuantitative Trait LociEpigenesis, GeneticGene Regulatory NetworksGenome-Wide Association Study

Keywords

BiologyGenome-wide association studyEpigeneticsDNA methylationGeneticsExpression quantitative trait lociQuantitative trait locusLocus (genetics)CpG siteSingle-nucleotide polymorphismGeneGene expressionGenotypeMultiple SclerosisQuantitative Trait LociHumansGene Regulatory NetworksEpigenesis, Genetic

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Additional file 1 of Unraveling the intercellular communication disruption and key pathways in Alzheimer’s disease: an integrative study of single-nucleus transcriptomes and genetic association

10.6084/m9.figshare.24934307.v1figshare

Additional file 1 of Unraveling the intercellular communication disruption and key pathways in Alzheimer’s disease: an integrative study of single-nucleus transcriptomes and genetic association

10.6084/m9.figshare.24934307figshare

Additional file 1 of Genome-wide multi-trait analysis of irritable bowel syndrome and related mental conditions identifies 38 new independent variants

10.6084/m9.figshare.26584017.v1figshare

Additional file 1 of Genome-wide multi-trait analysis of irritable bowel syndrome and related mental conditions identifies 38 new independent variants

10.6084/m9.figshare.26584017figshare

Additional file 2 of Genome-wide multi-trait analysis of irritable bowel syndrome and related mental conditions identifies 38 new independent variants

10.6084/m9.figshare.26584020.v1figshare

Additional file 2 of Genome-wide multi-trait analysis of irritable bowel syndrome and related mental conditions identifies 38 new independent variants

10.6084/m9.figshare.26584020figshare

Additional file 7 of Unraveling the intercellular communication disruption and key pathways in Alzheimer’s disease: an integrative study of single-nucleus transcriptomes and genetic association

10.6084/m9.figshare.26659003.v1figshare

Additional file 4 of Unraveling the intercellular communication disruption and key pathways in Alzheimer’s disease: an integrative study of single-nucleus transcriptomes and genetic association

10.6084/m9.figshare.26658994figshare

Additional file 5 of Unraveling the intercellular communication disruption and key pathways in Alzheimer’s disease: an integrative study of single-nucleus transcriptomes and genetic association

10.6084/m9.figshare.26658997figshare

Additional file 4 of Unraveling the intercellular communication disruption and key pathways in Alzheimer’s disease: an integrative study of single-nucleus transcriptomes and genetic association

10.6084/m9.figshare.26658994.v1figshare

Additional file 2 of Unraveling the intercellular communication disruption and key pathways in Alzheimer’s disease: an integrative study of single-nucleus transcriptomes and genetic association

10.6084/m9.figshare.24934656figshare

Additional file 3 of Unraveling the intercellular communication disruption and key pathways in Alzheimer’s disease: an integrative study of single-nucleus transcriptomes and genetic association

10.6084/m9.figshare.26658991.v1figshare

Additional file 6 of Unraveling the intercellular communication disruption and key pathways in Alzheimer’s disease: an integrative study of single-nucleus transcriptomes and genetic association

10.6084/m9.figshare.26659000figshare

Additional file 6 of Unraveling the intercellular communication disruption and key pathways in Alzheimer’s disease: an integrative study of single-nucleus transcriptomes and genetic association

10.6084/m9.figshare.26659000.v1figshare

Additional file 7 of Unraveling the intercellular communication disruption and key pathways in Alzheimer’s disease: an integrative study of single-nucleus transcriptomes and genetic association

10.6084/m9.figshare.26659003figshare

Additional file 5 of Unraveling the intercellular communication disruption and key pathways in Alzheimer’s disease: an integrative study of single-nucleus transcriptomes and genetic association

10.6084/m9.figshare.26658997.v1figshare

Additional file 2 of Unraveling the intercellular communication disruption and key pathways in Alzheimer’s disease: an integrative study of single-nucleus transcriptomes and genetic association

10.6084/m9.figshare.24934656.v1figshare

Additional file 3 of Unraveling the intercellular communication disruption and key pathways in Alzheimer’s disease: an integrative study of single-nucleus transcriptomes and genetic association

10.6084/m9.figshare.26658991figshare

Additional file 3 of Genome-wide multi-trait analysis of irritable bowel syndrome and related mental conditions identifies 38 new independent variants

10.6084/m9.figshare.26584023.v1figshare

Additional file 3 of Genome-wide multi-trait analysis of irritable bowel syndrome and related mental conditions identifies 38 new independent variants

10.6084/m9.figshare.26584023figshare